Tag: M.W=400-450

Kolthoff, I. M. published the artcileThe color changes of sulfonephthaleins, benzeins and phthaleins, Formula: C28H18O4, the publication is Journal of Physical Chemistry (1931), 1433-47, database is CAplus.

In an aqueous solution of phenolphthalein the concentration of the lactone form is of the order of 10,000 times greater than that of the carboxylic acid configuration. The equilibrium between the quinone and the quinone phenolate (anion) forms of the sulfonephthaleins in their alk. range quantitatively governs the color change. Benzeins which are not too little soluble in water have advantages over the corresponding sulfonephthaleins as indicators. α-Naphtholphthalein in aqueous solution is mainly present in the quinoid form. The color change of sulfonephthaleins, benzeins and phthaleins in acid medium is to be attributed to the weakly basic character of the quinone group. Thymol blue forms a hybrid ion in its color change in the acid range. By using the Fajans method of adsorbing cations on negatively charged AgCNS (with excess of CNS ions) or on positively charged AgCNS (if excess of Ag ions) and remembering that if the adsorbed ions are colored the precipitate will usually be colored, the colors of a number of indicator ions were determined By examining the behavior of dyestuffs as adsorption indicators it is possible to decide whether they are present in the form of cations or of anions.

Journal of Physical Chemistry published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Formula: C28H18O4.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Legradi, L. published the artcileMechanism of adsorption indication. IX. Phthaleins as adsorption indicators, Related Products of benzofurans, the publication is Acta Chimica Academiae Scientiarum Hungaricae (1971), 69(2), 157-61, database is CAplus.

α-Naphtholphthalein is suitable for the argentometric titration of Cl-, Br-, and NCS- ions; phenolphthalein for Br- and I- ions; and thymolphthalein for Cl-, Br-, and I- ions. The mixtures of thymolphthalein and α-naphtholphthalein or phenolphthalein and thymolphthalein are good adsorption indicators at pH 7-9; α-naphtholphthalein can be used without mading the solution alk. The phthalein indicators act on the basis of surface precipitation The Ag salt of the dye was detected on filter paper by a color reaction and was isolated by precipitation

Acta Chimica Academiae Scientiarum Hungaricae published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Related Products of benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Marquez, Luis Alberto Ponce published the artcileSynthesis and chemical study of some phenolic phthaleins and their halogenated derivatives, Product Details of C28H18O4, the publication is Anales de la Facultad de Farmacia y Bioquimica, Universidad Nacional Mayor de San Marcos (1950-57) (1956), 581-8, database is CAplus.

Various phenols were treated with ο-C₆H₄(CO)₂O to form the corresponding phthaleins (I) which were halogenated to halophthaleins (II). During the formation of I, the temperature must be maintained below 120° to avoid carbonization or volatilization of the reactants. The halogenation must be conducted in the cold under mildly alk. conditions to obtain good yields of II. Iodinated phthaleins lactonize readily.

Anales de la Facultad de Farmacia y Bioquimica, Universidad Nacional Mayor de San Marcos (1950-57) published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Product Details of C28H18O4.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Moir, James published the artcileColor and chemical constitution. XX. Some residual problems, Related Products of benzofurans, the publication is Transactions of the Royal Society of South Africa (1926), 131-8, database is CAplus.

cf. C. A. 19, 988. Locations of absorption bands are given for a considerable number of naphtholphthaleins, azo dyes, hydrazones, S compounds, and miscellaneous organic compounds Com. α-naphtholphthalein was shown to consist chiefly of a white substance (I) together with a small quantity of a brown substance (II). Apparently I is mostly the p,p’-isomer, with a little o,p (as with com. phenolphthalein); II is the o,o’-isomer, m. 234°.

Transactions of the Royal Society of South Africa published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Related Products of benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Novikova, E. N. published the artcileEffect of the inhibitors on the formation of peroxides in α-pinene, Recommanded Product: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Vestsi Akademii Navuk BSSR, Seryya Fizika-Tekhnichnykh Navuk (1957), 47-55, database is CAplus.

To a 25 mL. glass tube was added 4 mL. freshly distilled α-pinene (I), d₂₀ 0.8573, n²⁰_D 1.4665, b. 155-6°, containing 4 m mol inhibitor/100 mL. I, and the tube placed in an oil bath at 110° for air oxidation during 2 h. The amount of peroxides (II) formed was then determined iodometrically and calculated as ml. 0.1N hyposulfite solution/l. oxidized I. Secondary aromatic amines: dinaphthylphenylenediamine, p-H₂NC₆H₄NHPh, 2,4 – (H₂N)₂C₆H₃NHPh, 1,4 – diphenylenediamine, and p-HOC₆H₄NHPh caused total inhibition of the formation of II. Other equally effective inhibitors were p-hydroxyphenyl-β-naphthylamine, ο-, and p-aminophenol. The following aromatic compounds showed a much smaller inhibitory effect (in the decreasing order of the inhibitory efficiency): α-naphthol, phenyl-α-naphthylamine, nitrosodimethylamine, dihydroxynaphthalene, α-naphtholphthalein, hydroxyquinoline, phenyl-β-naphthylamine (III), and “aldol-α-naphthylamine” (titration values 1.5-10.1 mL. vs. 51.2-57.8 mL. for the controls), and hydroquinone (IV), pyrocatechol, pyrogallol, β-naphthol, β-naphthylamine, dianisidine, α-naphthylamine, phloroglucinol, resorcinol, Azatol A, p-toluidine, p-anisidine, nitroresorcinol, orcinol, m-tolylenediamine, ο-anthranilic acid, m-anthranilic acid, m-aminophenol, naphthalene, benzidine, ο-tolidine, hydroxyquinoline, and biphenyl (titration values from 11.8 to 50.4 mL.). Primary amines showed the lower inhibition. Naphthols were more effective than naphthylamines. ο- and p-Isomers of phenols and aminophenols inhibited formation of II more than did m-isomers. In another experiment, conducted on I and dipentene (fraction of turpentine, d₂₀ 0.8486, n²⁰_D 1.474, b. 174-5°), by using a dry O oxidation in a semivacuum at 80° 4 h., it was shown that the inhibitors are equally effective against formation of I in dry O as in the air. Addition of 0.005% Mn (as Mn stearate) to I did not increase the inhibitory effects of III and IV as found by the determinations of II and the O absorption by I. Triphenylphosphine and IV were found to be strong inhibitors against oxidation of terpenes. The inhibitory effects of the aromatic compounds against formation of II in I is discussed in the light of the chem. and structural nature of the inhibitors.

Vestsi Akademii Navuk BSSR, Seryya Fizika-Tekhnichnykh Navuk published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Recommanded Product: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Novikova, E. N. published the artcileEffect of substituents in molecules of inhibitors on their protective action in autoxidation of α-pinene, Name: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Zhurnal Obshchei Khimii (1958), 1993-7, database is CAplus.

The effect of various inhibitors on autoxidation and formation of peroxides in α-pinene was studied in scattered light at 18-20°. The inhibitors were added in 0.01 millimolar amount to 1 mole of pinene, and the reaction was permitted to occur in contact with air at room temperature for up to 150 days. Peroxide formation is hindered by pyrocatechol, pyrogallol, o- and p-aminophenols, p-hydroxydiphenylamine, dinaphthylphenylenediamine, 1,4-diphenylphenylenediamine, p-aminodiphenylamine, 1-naphthol, and p-hydroxypheyl-2-naphthylamine. Derivatives of phenols were weak inhibitors. Fe palmitate is an initiator for peroxidation of pinene. The activity of the inhibitor is determined both by the polarity of the substance and the mobility of available H atoms.

Zhurnal Obshchei Khimii published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Name: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Gustafsson, Charley published the artcileSpectrophotometric measurements on α-naphtholphthalein, Recommanded Product: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Suomen Kemistiseuran Tiedonantoja (1934), 17-23, database is CAplus.

α-Naphtholphthalein prepared according to Schulenberg (cf. C. A. 15, 80) was examined in the same way as the Sörensen-Palitsch preparation (cf. preceding abstract). The secondary and primary dissociation constants were, resp., 8.9 × 10^-8 and 5.5 × 10^-5. The secondary ion is blue in both cases, but the primary is orange-red for the former and yellow for the latter.

Suomen Kemistiseuran Tiedonantoja published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Recommanded Product: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Hosoi, Kazuo published the artcileCompetition between P1 [inorganic orthophosphate] and pH indictors in photosynthetic ATP formation in chromatophores of Rhodospirillum rubrum, Application In Synthesis of 596-01-0, the publication is Journal of Biochemistry (1973), 74(6), 1275-8, database is CAplus and MEDLINE.

The effects of 8 different pH indicators on the activities for ATP formation in the light and for ATP-Pi exchange in the dark in chromatophores from a carotenoidless mutant (G-9) of R. rubrum were studied. The ratio of the amount of dye bound to chromatophores to the total amount of dye added to the mixture were constant at appropriate concentrations Neither added ATP nor illumination influenced the amount of dye bound with chromatophores. Concentrations of 0.1mM α-naphtholphthalein and Bromcresol Green inhibited the activity for ATP formation and the ATP-Pi exchange but the bindings with chromatophores were ∼78% and 18%, resp., indicating that the binding of pH indicators was not essential for the inhibitions.

Journal of Biochemistry published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Application In Synthesis of 596-01-0.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Kato, Harutoshi published the artcilePrecise prediction of activators for the human constitutive androstane receptor using structure-based three-dimensional quantitative structure-activity relationship methods, Recommanded Product: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Drug Metabolism and Pharmacokinetics (2017), 32(3), 179-188, database is CAplus and MEDLINE.

The constitutive androstane receptor (CAR, NR1I3) regulates the expression of numerous drug-metabolizing enzymes and transporters. The upregulation of various enzymes, including CYP2B6, by CAR activators is a critical problem leading to clin. severe drug-drug interactions (DDIs). To date, however, few effective computational approaches for identifying CAR activators exist. In this study, we aimed to develop three-dimensional quant. structure-activity relationship (3D-QSAR) models to predict the CAR activating potency of compounds emerging in the drug-discovery process. Models were constructed using comparative mol. field anal. (CoMFA) based on the mol. alignments of ligands binding to CAR, which were obtained from ensemble ligand-docking using 28 compounds as a training set. The CoMFA model, modified by adding a lipophilic parameter with calculated logD_7.4 (S+logD_7.4), demonstrated statistically good predictive ability (r² = 0.99, q² = 0.74). We also confirmed the excellent predictability of the 3D-QSAR model for CAR activation (r²_pred = 0.71) using seven compounds as a test set for external validation. Collectively, our results indicate that the 3D-QSAR model developed in this study provides precise prediction of CAR activating potency and, thus, should be useful for selecting drug candidates with minimized DDI risk related to enzyme-induction in the early drug-discovery stage.

Drug Metabolism and Pharmacokinetics published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Recommanded Product: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Matsuo, Shigeru published the artcileSynthesis and characterization of new fluorescent poly(arylene ether)s, Application of 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (1994), 32(6), 1071-6, database is CAplus.

The poly(arylene ether)s were prepared by the nucleophilic aromatic substitution polymerization of phenolphthalin and its derivatives with activated aromatic difluorides. The polymers had glass transition temperatures of 210-240°. Though the monomers have no fluorescence, the resulting polymers fluoresced with a light green color in solid and solution states. The maximum excitation and emission wavelengths are 420 nm and 247 nm, resp. In the polymer solutions, the fluorescence intensity decreased gradually, but the intensity was recovered by heating the polymer at 220° for a few minutes. The fluorescent polymer had a stable radical. A model compound having the same repeating unit as the polymer was also prepared The fluorescence properties of this model were almost the same as those of the polymers.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Application of 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem