Tag: M.W=200-250

Kraus, George A. published the artcileCoupling reactions of methoxybutenynylcopper. A facile route to substituted indoles, Safety of 2-Iodobenzofuran, the publication is Tetrahedron Letters (1978), 3195-8, database is CAplus.

Cis-MeOCH:CHCCCu with 4,2-RR¹C₆H₃I (R = NO₂, H, Me, Cl, R¹ = H; R = H, R¹ = H, NO₂; R = MeO, R¹ = NO₂) in pyridine (85-125°, 10-12 h) gave 63-94% 4,2-RR¹C₆H₃CCCH:CHOMe (I). Cis–I (R = H, R¹ = NO₂) with KOH in refluxing MeOH (4 h) gave cis– and trans-2-O₂NC₆H₄CH:C(OMe)CH₂CH(OMe)₂ which on sequential hydrolysis (aqueous MeOH, ambient temperature, yield 55%) and reduction with Al-Hg (refluxing aqueous EtOH, yield 75%) gave indole II.

Tetrahedron Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Safety of 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Farmer, Jennifer L. published the artcileSolvent Choice and Kinetic Isotope Effects (KIEs) Dramatically Alter Regioselectivity in the Directed ortho Metalation (DoM) of 1,5-Dichloro-2,4-dimethoxybenzene, Quality Control of 69626-75-1, the publication is Chemistry – A European Journal (2015), 21(5), 1888-1893, database is CAplus and MEDLINE.

The regioselective formation of the 6-lithio derivative of 1,5-dichloro-2,4-dimethoxybenzene (i.e., 12) by directed ortho metalation (DoM) with nBuLi in THF is described. Although literature reports suggest direct deprotonation at C6, time-course and labeling studies revealed that deprotonation rather occurs exclusively at C3 followed by isomerization of the anion to C6. By contrast, when DoM was performed in Et₂O, deprotonation again occurred selectively at C3, but now no isomerization occurs, and electrophilic capture produces the regioisomer of that produced in THF. In these labeling studies, deuterium has an enormous kinetic isotope effect (KIE) that suppresses not only the original DoM reaction at C3 when deuterium is present there, but also suppresses isomerization to C6 when the label is at that site. Remarkably, this protecting-group role of the deuterium is unique to THF; in ether, full deprotonation of the deuterium at C3 was observed

Chemistry – A European Journal published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Quality Control of 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Olalere, Olusegun Abayomi published the artcileMicrostructural and microchemical characterization of valorized cola nitida pod wastes, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Chemical Data Collections (2020), 100356, database is CAplus.

The inherent environmental effects of the accumulated kola nut pod waste products have become a subject of discussion among many researchers. The need then arises for their alternative use as nutraceutical bioproducts. The phys. and chem. anal. techniques are often required for the standardization of these bioproducts in order to determine and maintain their quality characteristics. The dataset presented in this study provided information on the chem. profile, physisorption and thermo-anal. screening of Cola nut pod extracts Six sets of physicochem. methods were employed to characterize the phenolic extracts The result obtained clearly revealed the presence of two-hundred and fifty-five phenolic bioactive. Also presented was the thermal stability, morphol. and microstructural surface area configuration of the Cola nitida pod extracts The information obtained from this study could be used in determining the quality of food wastes bioproducts in nutria-pharmaceutical applications.

Chemical Data Collections published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Fiandanese, Vito published the artcileAn easy access to unsymmetrically substituted 4,4′-bis-1,2,3-triazoles, Application In Synthesis of 69626-75-1, the publication is Tetrahedron (2009), 65(51), 10573-10580, database is CAplus.

A convenient synthesis of 4-alkynyl-1,2,3-triazoles and novel unsym. substituted 4,4′-bi-1,2,3-triazole derivatives has been devised starting from easily available 1-trimethylsilyl-1,3-butadiyne. The starting compound was reacted with several azides, leading to 4-(silylalkynyl)-1,2,3-triazoles, which were easily transformed into 4-arylalkynyl-1,2,3-triazoles by a Pd catalyzed coupling reaction with aryl iodides, or into novel 4,4′-bis-1,2,3-triazole derivatives by a subsequent cyclization reaction with azides.

Tetrahedron published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Application In Synthesis of 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Fiandanese, Vito published the artcileA straightforward synthesis of indole and benzofuran derivatives, Recommanded Product: 2-Iodobenzofuran, the publication is Tetrahedron (2008), 64(1), 53-60, database is CAplus.

A methodol. for the synthesis of indole and benzofuran derivatives has been devised. The starting materials, ortho-substituted aryl diynes, have been easily converted into unsaturated bis-indolyl and bis-benzofuran derivatives and into 2-ethynylindole and 2-ethynylbenzofuran. Both these products have been further elaborated into more complex unsaturated indole-benzofuran and bis-benzofuran derivatives

Tetrahedron published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Recommanded Product: 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Fiandanese, Vito published the artcileA straightforward synthesis of benzofuran- and indole-substituted 1,2,3-triazoles via click chemistry, Computed Properties of 69626-75-1, the publication is Synthesis (2009), 3853-3859, database is CAplus.

A convenient synthesis of benzofuran- and indole-substituted 1,2,3-triazoles, e.g., I (R = H, I; X = O, NH), has been devised starting from easily available 2-silylalkynyl-substituted benzofuran and indole derivatives

Synthesis published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Computed Properties of 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Mongin, Florence published the artcileDeprotonation of furans using lithium magnesates, Quality Control of 69626-75-1, the publication is Tetrahedron Letters (2005), 46(46), 7989-7992, database is CAplus.

Furan was deprotonated on treatment with 1/3 equiv of Bu₃MgLi in THF at rt. The lithium arylmagnesate formed was either trapped with electrophiles or involved in a palladium-catalyzed cross-coupling reaction with 2-bromopyridine. The highly coordinated magnesate Bu₄MgLi₂ (1/3 equiv) proved to be a better deprotonating agent than Bu₃MgLi; the monitoring of the reaction using NMR spectroscopy showed that the deprotonation of furan at rt required 2 h whereas the subsequent electrophilic trapping was instantaneous. The method was extended to benzofuran, allowing its functionalization at C2 in high yields. The deprotonation of 2-methylfuran and lithium furfurylalkoxide at C5 turned out to be difficult, requiring either long reaction times or higher temperatures

Tetrahedron Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Quality Control of 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Zhang, Ling published the artcileDeconstructive Reorganization: De Novo Synthesis of Hydroxylated Benzofuran, Application of 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Angewandte Chemie, International Edition (2020), 59(12), 4670-4677, database is CAplus and MEDLINE.

An unprecedented deconstructive reorganization strategy for the de novo synthesis of hydroxylated benzofurans I [R = H, OH; R¹ = t-Bu, 3-thienyl, Ph, etc.; R² = H, OH, Me, OMe, 4-MeOC₆H₄S; R³ = H, OH, Ph, etc.] from kojic acid- or maltol-derived alkynes was reported. In this reaction, both the benzene and furan rings were simultaneously constructed, whereas the pyrone moiety of the kojic acid or maltol was deconstructed and then reorganized into the benzene ring as a six-carbon component. Through this strategy, at least one free hydroxyl group was introduced into the benzene ring in a substitution-pattern tunable fashion without protection-deprotection and redox adjustment. With this method, a large number of hydroxylated benzofuran derivatives with different substitution-patterns were prepared efficiently. This methodol. was shown as the key step in a collective total synthesis of hydroxylated benzofuran-containing natural products.

Angewandte Chemie, International Edition published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C34H33ClN6O7, Application of 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

He, Xi-xin published the artcileResearch on chemical ingredients of heartwood of root of morus atpropurpurea, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Tianran Chanwu Yanjiu Yu Kaifa (2014), 26(2), 193-196, database is CAplus.

Eight known compounds, including Moracin C(1), Moracin M(2), Dihydromorin(3), Oxyresveratrol(4), 2,4-Dihydroxy benzaldehyde(5), 7-Hydroxy coumarin(6), Daucosterol(7) and 3-Hydroxy-2-piperidinone(8) have been isolated from EtOH extract of heartwood of root of Morus atpropurpurea. Compounds 1, 3-6 and 8 were isolated from Morus atpropurpurea for the first time. Compound 8 was also isolated from Morus plant for the first time. Their antioxidant and neuroprotective activity were test by DPPH, MTT methods. Polyphenolic compounds 1-4 exhibited antioxidative and neuroprotective activities. Compound 2 showed significant neuroprotective activity at 20 μM.

Tianran Chanwu Yanjiu Yu Kaifa published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Zhang, Mi published the artcileChemical constituents of Chinese medicine Cortex Mori (II), Quality Control of 56317-21-6, the publication is Zhongguo Zhongyao Zazhi (2009), 34(12), 1601-1602, database is CAplus.

The chem. constituents of Chinese medicine Cortex Mori, the root bark of Morus alba, was isolated and purified with silica gel and gel column chromatog., and obtained compounds were identified by physico-chem. properties and spectroscopic data. 11 Compounds were isolated and identified, including moracin C (1), moracin M (2), moracin M-3′-O-β-D-glucopyranoside (3), moracin O (4), kuwanon S (5), kuwanon T (6), 5,7-dihydroxychromone (7), 5,7,2′-trihydroxyflavanone-4′-O-β-D-glucoside (steppogenin-4′-O-β-D-glucoside) (8), 7-hydroxycoumarin (9), 5,7-dihydroxycoumarin-7-O-β-D-glucopyranoside (10), and mullberroside C (11). Compound (8) was firstly isolated from this genus, and compounds 2, 4, 6 were firstly isolated from this plant.

Zhongguo Zhongyao Zazhi published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C12H15ClO3, Quality Control of 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem