Tag: M.W=200-250

Ndungu, J. Maina published the artcileDevelopment of an Anomalous Heck Reaction: Skeletal Rearrangement of Divinyl and Enyne Carbinols, COA of Formula: C8H5IO, the publication is Organic Letters (2005), 7(26), 5845-5848, database is CAplus and MEDLINE.

A general set of conditions that achieves the union of aryl halides and divinyl or enyne carbinols to afford tri- or tetrasubstituted olefins in good yields (up to 83%) is described. E.g., reaction of BrPh and CH₂:CHCH(OH)CMe:CH₂ in presence of PdCl₂(PPh₃)₂, i-Pr₂NEt, and Et₄NCl gave olefin I. The mechanism by which this proceeds is believed to involve the intermediacy of a cyclopropanol, followed by a novel skeletal reorganization. The ability to suppress β-hydride elimination of organopalladium intermediates appears to be critical to the success of these processes.

Organic Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, COA of Formula: C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Kapche, Deccaux W. F. G. published the artcileAryl benzofuran derivatives from the stem bark of Calpocalyx dinklagei attenuate inflammation, HPLC of Formula: 56317-21-6, the publication is Phytochemistry (Elsevier) (2017), 70-79, database is CAplus and MEDLINE.

Calpocalyx dinklagei Harms (Fabaceae) is a tropical medicinal tree, which is indigenous to Western Africa. A phytochem. study of this local plant species from its stem bark has led to the isolation of two previously undescribed aryl benzofuran derivatives, named dinklagein A (I) and B (II), together with eight known compounds Their chem. structures were elucidated by use of extensive spectroscopic methods (IR, HREI-MS and 1D and 2D NMR). Among all isolates, dinklagein A displayed remarkably potent inhibitory activity against the production of nitric oxide (NO) in the lipopolysaccharide (LPS) induced RAW264.7 macrophages. SAR and mol. docking investigations on iNOS and previously undescribed compounds (dinklagein A and B) supported exptl. data. Furthermore, dinklagein A dose dependently suppressed the LPS-stimulated iNOS expression at both mRNA and protein level. It also attenuated IL-1β release, mRNA expressions of IL-1β and COX-2 at low doses. These results suggest that dinklagein A can be developed as natural, multi-target agent against several inflammatory diseases.

Phytochemistry (Elsevier) published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, HPLC of Formula: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Liu, Xi-Hai published the artcileCopper-mediated aerobic iodination and perfluoroalkylation of boronic acids with (CF₃)₂CFI at room temperature, Synthetic Route of 69626-75-1, the publication is Journal of Fluorine Chemistry (2016), 59-67, database is CAplus.

The copper-mediated aerobic reactions between the branched (CF₃)₂CFI and boronic acids (R-B(OH)₂) are described. Different from the linear perfluoroalkyl analogs CF₃(CF₂)_nI (n = 2, 3, 5, 7), (CF₃)₂CFI reacting with R-B(OH)₂ at room temperature under air in the presence of catalytic Cu powder provided exclusively the corresponding iodides (R-I), while the aerobic reactions of arylboronic acids with (CF₃)₂CFI at room temperature in the presence of Cu(OAc)₂ gave the perfluoroalkylation products (R-CF(CF₃)₂) in acceptable to moderate yields. The iodination reaction could be further promoted by hydroquinone, the addition of which improved the oxidation ability of (CF₃)₂CFI and provided the ipso-iodination products in high yields. The perfluoroalkylation was facilitated by the copper carboxylates since the addition of these salts into the reaction mixtures could successfully give rise to Ar-CF(CF₃)₂.

Journal of Fluorine Chemistry published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Synthetic Route of 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Snegaroff, Katia published the artcileDeprotonative Metalation of Functionalized Aromatics Using Mixed Lithium-Cadmium, Lithium-Indium, and Lithium-Zinc Species, Recommanded Product: 2-Iodobenzofuran, the publication is Chemistry – A European Journal (2009), 15(39), 10280-10290, S10280/1-S10280/16, database is CAplus and MEDLINE.

In situ mixtures of CdCl₂.TMEDA (0.5 equiv; TMEDA = N,N,N’,N’-tetramethylethylenediamine) or InCl₃ (0.33 equiv) with [Li(tmp)] (tmp = 2,2,6,6-tetramethylpiperidino; 1.5 or 1.3 equiv, resp.) were compared with the previously described mixture of ZnCl₂.TMEDA (0.5 equiv) and [Li(tmp)] (1.5 equiv) for their ability to deprotonate anisole, benzothiazole, and pyrimidine. [(Tmp)₃CdLi] proved to be the best base when used in THF at room temperature, as demonstrated by subsequent trapping with iodine. The Cd-Li base then proved suitable for the metalation of a large range of aromatics including benzenes bearing reactive functional groups (CONEt₂, CO₂Me, CN, COPh) or heavy halogens (Br, I), and heterocycles (from the furan, thiophene, pyrrole, oxazole, thiazole, pyridine, and diazine series). Five-membered heterocycles benefiting from doubly activated positions were similarly dideprotonated at room temperature The aromatic lithium cadmates thus obtained were involved in palladium-catalyzed cross-coupling reactions or simply quenched with acid chlorides.

Chemistry – A European Journal published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H11BrN2, Recommanded Product: 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Wu, Xuewei published the artcileTwo new 2-arylbenzofuran derivatives from the leaves of Morus alba, Safety of 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Natural Product Research (2019), 33(2), 204-211, database is CAplus and MEDLINE.

Two new 2-arylbenzofuran derivatives, moracinfurol A and B (1-2), and 10 known compounds (3-12) were isolated from the leaves of M. alba. Their structures were determined on the basis of spectroscopic anal. including 1D and 2D NMR and HR-ESI-MS. All of the 2-arylbenzofuran derivatives were evaluated for cytotoxicity against A549 cells with compounds 2, 4, 6-8, and 12 exhibiting moderate activity. Some cytotoxic 2-arylbenzofuran derivatives might induce autophagy characterized by the accumulation of LC-3 II.

Natural Product Research published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C8H8O3, Safety of 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Royer, Mariana published the artcileSecondary metabolites of Bagassa guianensis Aubl. wood: A study of the chemotaxonomy of the Moraceae family, HPLC of Formula: 56317-21-6, the publication is Phytochemistry (Elsevier) (2010), 71(14-15), 1708-1713, database is CAplus and MEDLINE.

In order to explain the durability of the Moraceae plant family, phytochem. of Bagassa guianensis was performed. Et acetate extract was obtained from the heartwood and 18 secondary metabolites were isolated, including 6 moracins [6-O-methyl-moracin M, 6-O-methyl-moracin N and moracin Z; previously identified: moracin M, moracin N and moracin P], 8 stilbenoids [presently identified: (-)-epialboctalol and arachidin 4; previously identified: alboctalol, trans-resveratrol, arachidin 2, trans-oxyresveratrol and artogomezianol], 3 previously identified flavonoids, steppogenin, katuranin and dihydromorin, β-sitosterol and resorcinol. Previous studies suggest that stilbenoids are responsible for the natural durability of wood. This study has determined that B. guianensis is closely related to Morus sp. in phylogeny and should be included in the Moreae sensu stricto tribe of the Moraceae family.

Phytochemistry (Elsevier) published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, HPLC of Formula: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Vo, Quan V. published the artcileThe radical scavenging activity of moracins: theoretical insights, Related Products of benzofurans, the publication is RSC Advances (2020), 10(60), 36843-36848, database is CAplus and MEDLINE.

Moracins are natural products that have been isolated from different plants such as Artocarpus heterophyllus, Cassia fistula, Morus alba, and Morus mesozygia. Studies showed that moracins may have various advantageous physiol. effects such as anticancer, anti-inflammatory, anticholinesterase and particularly antioxidant activities. Most of these bioactivities have not been studied systematically. In this study, the radical scavenging of a typical moracin (moracin M, MM) against HO and HOO radicals was evaluated by thermodn. and kinetic calculations in the gas phase as well as in water and pentyl ethanoate solvents. It was found that the overall rate constants for the HO radical scavenging in the gas phase and the physiol. environments are in the range of 10¹¹ to 10¹⁰ M^-1 s^-1, resp. For the HOO + MM reaction the rate constants are 4.10 x 10⁷ and 3.80 x 10⁴ M^-1 s^-1 in the polar and lipid media, resp. It is important to notice that the single electron transfer pathway of the anion state (MM-O6′-) dominated the HOO radical scavenging in the aqueous solution, whereas in lipid medium the neutral MM exerted its activity by the formal hydrogen transfer mechanism. The HOO radical scavenging of MM is comparable to that of Trolox in lipid medium, whereas it is 315.4 times more active in the polar environment.

RSC Advances published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C20H18BrN3, Related Products of benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Matsuzawa, Tsubasa published the artcileTransition-Metal-Free Synthesis of N-Arylphenothiazines through an N- and S-Arylation Sequence, Quality Control of 69626-75-1, the publication is Organic Letters (2021), 23(6), 2347-2352, database is CAplus and MEDLINE.

An efficient synthetic method of N-arylphenothiazines, e.g., I, from o-sulfanylanilines under transition-metal-free conditions is disclosed. An N- and S-arylation sequence of o-sulfanylanilines enabled the authors to synthesize a wide variety of N-arylphenothiazines. In particular, one-pot synthesis of N-arylphenothiazines was accomplished from easily available modules through preparation of o-sulfanylanilines by thioamination of aryne intermediates and following N- and S-arylation sequence.

Organic Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Quality Control of 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Liu, Ai-hong published the artcileChemical constituents occurring in roots of Artocarpus nanchuanensis, HPLC of Formula: 56317-21-6, the publication is Zhongguo Shiyan Fangjixue Zazhi (2014), 20(22), 91-94, database is CAplus.

The chem. constituents of roots of Artocarpus nanchuanensis were studied. The constituents were isolated from the Et acetate portion of 95% ethanol extraction of A. nanchuanensis roots by column chromatog. over silica gel, Diaion HP20 macroreticular resin, MCI CHP 20P gel, Sephadex LH-20 gel, ODS gel, etc. Their structures were elucidated by anal. of phys. chem. properties and spectral data. Nine compounds were isolated and their structures were identified as p-hydroxybenzaldehyde (1), 2,4-dihydroxybenzoic acid (2), p-coumaric acid (3), (+)-catechin (4), (E)-ferulic acid Me ester (5), p-E-hedroxycinnamic acid Me ester (6), norartocarpetin (7), trans-oxyresveratrol (8) and moracin M (9). Compounds 1, 2, 5 and 6 were isolated from Moraceae for the first time. Compound 3 was firstly reported in the genus Artocarpus, and compounds 7-9 were characterized in A. nanchuanensis for the first time.

Zhongguo Shiyan Fangjixue Zazhi published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, HPLC of Formula: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Hao, Mimi published the artcileBioactive flavonoids and stilbenes from the leaf of Morus alba var. multicaulis, SDS of cas: 56317-21-6, the publication is Fitoterapia (2021), 105018, database is CAplus and MEDLINE.

Twenty-two flavonoids and stilbenes (1-22) were obtained from the leaf of Morus alba var. multicaulis. Among them, morusalbanosides A (1), B1 (2), and B2 (3) were new compounds Moreover, compounds 1, 3, 4-11, 15-18, and 22 displayed inhibitory effects on triglyceride (TG) accumulation in HepG2 cells in a concentration dependent manner. Furthermore, compounds 1, 3, 11, and 22 could activate the phosphorylation of AMP-activated protein kinase α (AMPKα), reduce the synthesis of TG by inhibiting the expression of fatty acid synthase (FAS) and stearoyl-CoA desaturase 1 (SCD1). While, only compounds 1 and 11 could promote the phosphorylation of acetyl-CoA carboxylase 1 (ACC1) and accelerate the oxidation of fatty acids by up-regulating carnitine palmitoyltransferase 1A (CPT1A). In brief, this study found that most of the researched flavonoids and stilbenes could regulate TG metabolism in vitro. They might play the role by up-regulating phosphorylation of AMPKα, inhibiting TG biosynthesis, and promoting the oxidation of fatty acids.

Fitoterapia published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, SDS of cas: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem