Tag: M.W=200-250

Kortman, Gregory D. published the artcileCopper-Catalyzed Hydroarylation of Internal Alkynes: Highly Regio- and Diastereoselective Synthesis of 1,1-Diaryl, Trisubstituted Olefins, HPLC of Formula: 69626-75-1, the publication is ACS Catalysis (2017), 7(9), 6220-6224, database is CAplus.

The copper-catalyzed hydroarylation of internal, unsym. alkynes is presented. Trisubstituted alkenes are obtained as single diastereomers in good to excellent yields and excellent regioselectivities. The scope of the reaction is presented with respect to alkyne and aryl iodide coupling partners. Initial mechanistic experiments indicate a hydrocupration event followed by a two-electron oxidative addition/reductive elimination pathway.

ACS Catalysis published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, HPLC of Formula: 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Kakiya, Hirotada published the artcileReaction of gem-dibromocyclopropanes or iodobenzofuran with trialkylmanganate, Category: benzofurans, the publication is Tetrahedron (2000), 56(15), 2131-2137, database is CAplus.

Treatment of gem-dibromocyclopropanes with trialkylmanganate, derived from manganese(II) chloride and three equivalent of Grignard reagent or alkyllithium, followed by an addition of electrophiles provided dialkylated cyclopropanes in good yields. It was found that the reaction of gem-dibromocyclopropanes with alkylmagnesium halide proceeded in the presence of a catalytic amount of manganese(II) chloride. The use of iodobenzofuran in place of gem-dibromocyclopropane gave a ring opening product, 2-alkenylphenol.

Tetrahedron published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Category: benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Tada, Atsuko published the artcileExamination of original plant of mulberry bark extract, a natural food additive, based on composition of the constituents, Related Products of benzofurans, the publication is Shokuhin Eiseigaku Zasshi (2011), 52(4), 258-264, database is CAplus and MEDLINE.

Mulberry bark extract, a natural food additive, is described as a “root bark extract from Morus bombycis” (Japanese name: Yamaguwa) in the Notice (1996) relating to existing food additives used in Japan. The results of analyses by LC/UV and LC/MS suggested that the Mulberry bark extract products that were tested were actually made from the root bark of Morus alba (Japanese name: Maguwa) or its hybrid species, because the compositions of the constituents in the products are more similar to those in the extracts of the dried root bark of M. alba and hybrid species that are cultivated in Japan than to those of M. bombycis. In addition, the constituents of the food additive products were different from those of the natural medicine Mori Cortex products (‘Souhakuhi’ in Japanese) made from the root bark of mulberry grown in China, and which is described as being derived from M. alba in the Japanese pharmacopoeia. These results were also corroborated by Principal Component Anal. using the peak areas of LC/MS anal. as explanatory variables. After this study, it was decided that Mulberry bark extract is one of the existing food additives that should be excluded from the list this year in Japan.

Shokuhin Eiseigaku Zasshi published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C10H15ClO3S, Related Products of benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Choi, Sang Won published the artcileAnalysis of functional constituents in mulberry (Morus alba L.) twigs by different cultivars, producing areas, and heat processings, Synthetic Route of 56317-21-6, the publication is Preventive Nutrition and Food Science (2013), 18(4), 256-262, database is CAplus and MEDLINE.

Four functional constituents, oxyresveratrol 3′-O-β-D-glucoside (ORTG), oxyresveratrol (ORT), t-resveratrol (RT), and moracin (MC) were isolated from the ethanolic extract of mulberry (Morus alba L.) twigs by a series of isolation procedures, including solvent fractionation, and silica-gel, ODS-A, and Sephadex LH-20 column chromatogs. Their chem. structures were identified by NMR and FABMS spectral anal. Quant. changes of four phytochems. in mulberry twigs were determined by HPLC according to cultivar, producing area, and heat processing. ORTG was a major abundant compound in the mulberry twigs, and its levels ranged from 23.7 to 105.5 mg% in six different mulberry cultivars. Three other compounds were present in trace amounts (<1 mg/100 g) or were not detected. Among mulberry cultivars examined, “Yongcheon” showed the highest level of ORTG, whereas “Somok” had the least ORTG content. Levels of four phytochems. in the mulberry twigs harvested in early Sept. were higher than those harvested in early July. Levels of ORTG and ORT in the “Cheongil” mulberry twigs produced in the Uljin area were higher than those produced in other areas. Generally, levels of ORTG and ORT in mulberry twigs decreased with heat processing, such as steaming, and microwaving except roasting, whereas those of RT and MC did not considerably vary according to heat processing. These results suggest that the roasted mulberry twigs may be useful as potential sources of functional ingredients and foods.

Preventive Nutrition and Food Science published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Synthetic Route of 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Kang, Yu Jin published the artcileA zig-zag type bidibenzofuran based host material for green phosphorescent organic light-emitting diodes, Recommanded Product: 2-Iodobenzofuran, the publication is Dyes and Pigments (2015), 278-282, database is CAplus.

A zig-zag type carbazole modified bidibenzofuran compound, 2,2′-di(carbazol-9-yl)-4,4′-bidibenzo[b,d]furan, was synthesized as the host material for green phosphorescent organic light-emitting diodes by coupling 2 9-(dibenzo[b,d]furan-2-yl)carbazole moieties via 4- position of dibenzofuran. The carbazole modified bidibenzofuran host showed a triplet energy of 2.75 eV and the HOMO/the LUMO of -6.10 eV/-2.87 eV for hole and electron injection. The bidibenzofuran host was doped with green emitting tris(2-phenylpyridine) Ir and high quantum efficiency of 20.6% was achieved in the green phosphorescent organic light-emitting diodes.

Dyes and Pigments published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Recommanded Product: 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Dat, Nguyen Tien published the artcileHypoxia-inducible factor-1 inhibitory benzofurans and chalcone-derived Diels-Alder adducts from Morus species, Name: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Journal of Natural Products (2009), 72(1), 39-43, database is CAplus and MEDLINE.

Hypoxia-inducible factor-1 (HIF-1) is the central mediator of cellular responses to low oxygen concentrations and vital to many aspects of cancer biol. Bioassay-guided fractionation of the chloroform-soluble extracts of Morus species using a hypoxia response element (HRE)-dependent reporter assay led to identification of six benzofurans (1-6) and two chalcone-derived Diels-Alder adducts (7, 8) from Mori Cortex Radicis and three prenylated benzofurans (9-11) and four chalcone-derived Diels-Alder adducts (12-15) from Morus bombycis. The structure of the new 2-arylbenzofuran-type compound, moracin Q (3), was elucidated by spectroscopic methods, and the absolute configuration of 2 was determined for the first time. The selected compounds (1-3, 5, 7, 9, 10, and 12) from the cell-based reporter assay were found to inhibit hypoxia-induced HIF-1α accumulation in a dose-dependent manner in human hepatocelluar carcinoma cell-line Hep3B cells. Furthermore, these compounds were also active against hypoxia-induced vascular endothelial growth factor (VEGF) secretion in Hep3B cells.

Journal of Natural Products published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Name: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Li, Hong Xu published the artcileLipolytic effect of compounds isolated from leaves of mulberry (Morus alba L.) in 3T3-L1 adipocytes, Related Products of benzofurans, the publication is Natural Product Research (2018), 32(16), 1963-1966, database is CAplus and MEDLINE.

In this study, 19 known compounds were isolated from mulberry (Morus alba L.) leaves. The lipid accumulation inhibitory activity of the isolated compounds was investigated. Compounds and showed good anti-adipogenic activity based on 3T3-L1 adipocytes with values of 36.6 ± 9.0 and 34.7 ± 4.0%, resp. In addition, compounds , and showed significant inhibitory activity with values from 15.4 to 21.2% and compounds , – and – exhibited weak activity with values ranging from 2.1 to 10.7% at a concentration of 40.0 μM. These results show the potentiality that mulberry leaf is an excellent inhibitory phytochem. source against lipid accumulation.

Natural Product Research published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Related Products of benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Jeong, Ji Yeon published the artcilePancreatic lipase inhibitory constituents from Morus alba leaves and optimization for extraction conditions, HPLC of Formula: 56317-21-6, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(11), 2269-2274, database is CAplus and MEDLINE.

The leaves of Morus alba (Moraceae) have been traditionally used for the treatment of metabolic diseases including diabetes and hyperlipidemia. Thus, inhibitory effect of M. alba leaves on pancreatic lipase and their active constituents were investigated in this study. Twenty phenolic compounds including ten flavonoids, eight benzofurans, one stilbene and one chalcones were isolated from the leaves of M. alba. Among the isolated compounds, morachalcone A (20) exerted strong pancreatic lipase inhibition with IC₅₀ value of 6.2 μM. Other phenolic compounds containing a prenyl group showed moderate pancreatic lipase inhibition with IC₅₀ value of <50 μM. Next, extraction conditions with maximum pancreatic lipase inhibition and phenolic content were optimized using response surface methodol. with three-level-three-factor Box-Behnken design. Our results suggested the optimized extraction condition for maximum pancreatic lipase inhibition and phenolic content as ethanol concentration of 74.9%; temperature 57.4 °C and sample/solvent ratio, 1/10. The pancreatic lipase inhibition and total phenolic content under optimized condition were found to be 58.5% and 26.2 μg GAE (gallic acid equivalent)/mg extract, resp., which were well matched with the predicted value.

Bioorganic & Medicinal Chemistry Letters published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, HPLC of Formula: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Chen, Doris published the artcileIntramolecular, Interrupted Homo-Nazarov Cascade Biscyclizations to Angular (Hetero)Aryl-Fused Polycycles, Recommanded Product: 2-Iodobenzofuran, the publication is Chemistry – A European Journal, database is CAplus and MEDLINE.

A SnCl₄-catalyzed intramol., interrupted homo-Nazarov cascade biscyclization to access angular (hetero)aryl-fused polycycles was reported. Subsequent decarboxylation of the readily enolizable products afforded the angular products in up to 71 % yield over two steps, with the trans-diastereomers as the major products. The cyclopropyl homo-Nazarov cyclization precursors were formed using a scalable and modular synthetic route that, ultimately, offers access to 6,6,6-, 6,6,5-, 6,5,6-, 6,6,5,6-, and 6,6,6,5-fused angular polycyclic products. To showcase the rigor and utility of the method, an 8-step total synthesis of (±)-1-oxoferruginol, an antibacterial aromatic abietane diterpenoid, was disclosed.

Chemistry – A European Journal published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Recommanded Product: 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Park, Ji-Hae published the artcileTwo new isoarylbenzofuran diglucosides from the root bark of Morus alba, Synthetic Route of 56317-21-6, the publication is Journal of Asian Natural Products Research (2015), 17(4), 357-363, database is CAplus and MEDLINE.

Two new arylbenzofuran diglucopyranosides, (2”R)-(-)-moracin-O-5′,3”-β-D-diglucopyranoside (1) and (2”R)-(-)-moracin-P-5′,2”-β-D-diglucopyranoside (2), along with known arylbenzofurans, moracin M 6-β-D-glucopyranoside (3), and an isomeric mixture of R-(-)-moracin O (4) and R-(-)-moracin P (5), were isolated from the root bark of Morus alba L. The structure of the compounds was elucidated based on mass spectrometry, IR, 1D and 2D NMR spectroscopic data.

Journal of Asian Natural Products Research published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Synthetic Route of 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem