Tag: M.W:100-200

Chemistry, like all the natural sciences, Computed Properties of C6H8O2, begins with the direct observation of nature— in this case, of matter.14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, SMILES is O=C1C(C)OC(C)=C1, belongs to benzofurans compound. In a document, author is Lee, Jongkook, introduce the new discover.

Potential Moracin M Prodrugs Strongly Attenuate Airway Inflammation In Vivo

This study aims to develop new potential therapeutic moracin M prodrugs acting on lung inflammatory disorders. Potential moracin M prodrugs (KW01-KW07) were chemically synthesized to obtain potent orally active derivatives, and their pharmacological activities against lung inflammation were, for the first time, examined in vivo using lipopolysaccharide (LPS)-induced acute lung injury model. In addition, the metabolism of KVV02 was also investigated using microsomal stability test and pharmacokinetic study in rats. When orally administered, some of these compounds (30 mg/kg) showed higher inhibitory action against LPSinduced lung inflammation in mice compared to moracin M. Of them, 2-(3,5-bis((dimethylcarbamoyl)oxy)phenyl)benzofuran-6-yl acetate (KVV02) showed potent and dose-dependent inhibitory effect on the same animal model of lung inflammation at 1, 3, and 10 mg/kg. This compound at 10 mg/kg also significantly reduced IL-1 beta concentration in the bronchoalveolar lavage fluid of the inflamed-lungs. KVV02 was rapidly metabolized to 5-(6-hydroxybenzofuran-2-yl)-1,3-phenylene bis(dimethylcarbamate) (KW06) and moracin M when it was incubated with rat serum and liver microsome as expected. When KVV02 was administered to rats via intravenous or oral route, KVV06 was detected in the serum as a metabolite. Thus, it is concluded that KVV02 has potent inhibitory action against LPS-induced lung inflammation. It could behave as a potential prodrug of moracin M to effectively treat lung inflammatory disorders.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 14400-67-0. Computed Properties of C6H8O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is an experimental science, Safety of 2,5-Dimethylfuran-3(2H)-one, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, belongs to benzofurans compound. In a document, author is Jaradat, Nidal.

Phytochemistry, traditional uses and biological effects of the desert plant Styrax officinalis L

Styrax officinalis L. is an important medicinal plant that grows in the desert, subtropics, temperate climate, and Mediterranean Basin regions.. It has been used for medicinal, religious, agricultural and cosmetic purposes. This review aimed to collect from the literature, all the available data about the phytochemistry, traditional medicinal uses, evidence-based uses, morphology and habitat of S. officinalis plant. This report is a review of the literature concerning S. officinalis chemical constituents, description, origin, traditional medicinal and evidence-based uses published from 1966 to date. Among the databases searched for primary literature references are Pubmed, Scientific Information Database, Scopus, Web of Science, Science Direct, Google and Google scholar. In this search, combinations of the keyword Styrax officinalis with the terms; antibacterial, antifungal, antioxidant, anticancer, phytochemistry, ethnopharmacology, traditional uses, folk uses, morphology, biological activity, therapeutic effects and toxicity were applied. The current review showed that various compounds have been isolated from S. officinalis: leaves, fruits, seeds, flowers and stems such as egonol, egonol oleate, americanin, several types of phenolic acids and benzofuran derivatives. These natural compounds and their synthetic derivatives in addition to the various parts used as extracts showed valuable biological activities including antitumor, hemolytic, anti-complement, anti-leukemic, antifungal, antibacterial, antioxidant and tyrosinase inhibitory activities. This review represented a summary of the information concerning S. officinalis different used parts. However, the areas of isolation and identification of the biologically active compounds of S. officinalis from the roots and rhizomes also investigation more biological activities of other plant parts are essential to cover all the scientific fields of S. officinalis.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 14400-67-0. Safety of 2,5-Dimethylfuran-3(2H)-one.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 97148-39-5, Name is Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate, molecular formula is C7H10N2O4. In an article, author is Yadav, Seema,once mentioned of 97148-39-5, SDS of cas: 97148-39-5.

Well-Defined N-Heterocyclic Carbene-Palladium Complexes as Efficient Catalysts for Domino Sonogashira Coupling/Cyclization Reaction and C-H bond Arylation of Benzothiazole

Well-defined and air-stable PEPPSI (Pyridine Enhanced Precatalyst Preparation Stabilization and Initiation) themed palladium bis-N-heterocyclic carbene complexes have been developed for the domino Sonogashira coupling/cyclization reaction of 2-iodophenol with a variety of terminal alkynes and C-H bond arylation of benzothiazole with aryl iodides. The PEPPSI themed palladium complexes, 2a and 2b were synthesized in good yields from the reaction of corresponding imidazolium salts with PdCl2 and K2CO3 in pyridine. The new air-stable palladium-NHC complexes were characterized by NMR spectroscopy, X-ray crystallography, elemental analysis, and mass spectroscopy studies. The PEPPSI themed palladium(II) bis-N-heterocyclic carbene complexes 2a and 2b exhibited excellent catalytic activities for domino Sonogashira coupling/cyclization reaction of 2-iodophenol with terminal alkynes yielding benzofuran derivatives. In addition, the palladium complexes, 2a and 2b successfully catalyzed the direct C-H bond arylation of benzothiazole with aryl iodides as coupling partners in presence of CuI as co-catalyst.

Interested yet? Keep reading other articles of 97148-39-5, you can contact me at any time and look forward to more communication. SDS of cas: 97148-39-5.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Wang, Xiaomin, once mentioned the application of 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, molecular weight is 112.13, MDL number is MFCD00052571, category is benzofurans. Now introduce a scientific discovery about this category, Category: benzofurans.

Psoralen inhibits malignant proliferation and induces apoptosis through triggering endoplasmic reticulum stress in human SMMC7721 hepatoma cells

BackgroundPsoralen is a coumarin-like and coumarin-related benzofuran glycoside, which is a commonly used traditional Chinese medicine to treat patients with kidney and spleen-yang deficiency symptom. Psoralen has been reported to show estrogen-like activity, antioxidant activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity. However, the antitumor mechanism of psoralen is not fully understood. This study aimed to investigate the therapeutic efficacy of psoralen in human hepatoma cell line SMMC7721 and the mechanism of antitumor effects.ResultsPsoralen inhibited proliferation of SMMC7721 in a dose- and time-dependent manner, and promoted apoptosis. Further, psoralen activated the ER stress signal pathway, including the expansion of endoplasmic reticulum, increasing the mRNA levels of GRP78, DDIT3, ATF4, XBP1, GADD34 and the protein levels of GDF15, GRP78, IRE1 alpha, XBP-1s in a time-dependent manner. Psoralen induces cell cycle arrest at G1 phase by enhancing CyclinD1 and reducing CyclinE1 expression. Moreover, TUDC couldn’t inhibit the psoralen-induced ER stress in SMMC7721 cells.ConclusionsPsoralen can inhibit the proliferation of SMMC7721 cells and induce ER stress response to induce cell apoptosis, suggesting that psoralen may represent a novel therapeutic option for the prevention and treatment hepatocellular carcinoma.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 14400-67-0, Category: benzofurans.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 97148-39-5, Name is Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate, molecular formula is C7H10N2O4. In an article, author is Bao, Xiaoze,once mentioned of 97148-39-5, Name: Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate.

Bidirectional enantioselective synthesis of bis-benzofuran atropisomeric oligoarenes featuring two distal C-C stereogenic axes

We report the bidirectional enantioselective synthesis of bis-benzofuran atropisomeric oligoarenes featuring two distal C-C stereogenic axes obtained by a two-fold central-to-axial chirality conversion upon oxidative aromatization. The key enantioenriched centrally chiral bis-dihydrobenzofuran precursors were synthesized via a bidirectional diastereo- and enantio-selective organocatalyzed domino reaction between simple achiral and easily accessible dihydroxylated aromatics and chloronitroalkenes. Moreover, the stereodivergent nature of the methodology was established by synthesizing both diastereomers of a non-symmetrically functionalized bis-axially chiral oligoarene.

Interested yet? Keep reading other articles of 97148-39-5, you can contact me at any time and look forward to more communication. Name: Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem