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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Production of ethyl 4-chloro-3-hydroxybutanoate with resting cells of Sulfolobus solfataricus, the main research direction is chloroacetoacetate asym reduction Sulfolobus; chiral chlorohydroxybutanoate production Sulfolobus.Safety of (R)-Ethyl 4-chloro-3-hydroxybutanoate.

The thermophilic archaebacterium S. solfataricus converted Et 4-chloroacetoacetate to Et (R)-4-chloro-3-hydroxybutanoate in 97% yield, with 98% enantiomeric excess. Ten g wet cells were suspended in 100 mL pH 5 acetate buffer containing 5 mL propan-2-ol and 1 g (60 mM) substrate. After 24 h at 30°, the supernatant was extracted with ether and the product purified by HPLC. Concentrations of substrate >60 mM led to decreased yields.

There is still a lot of research devoted to this compound(SMILES：O=C(OCC)C[C@@H](O)CCl)Safety of (R)-Ethyl 4-chloro-3-hydroxybutanoate, and with the development of science, more effects of this compound(90866-33-4) can be discovered.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Computed Properties of C6H11ClO3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Stereochemical control in microbial reduction. Part 13. A novel method to synthesize (L)-β-hydroxyl esters by the reduction with bakers’ yeast. Author is Nakamura, Kaoru; Kawai, Yasushi; Ohno, Atsuyoshi.

RCH2COCH2CO2R1 (R = R1 = Me; R = H, Cl, Me, CF3, R1 = Et) were reduced stereoselectively to (L)-RCH2CH(OH)CH2CO2R1 (enantiomeric excess of 80-94%) with baker’s yeast in the presence of ClCH2CO2Et (I). I works by inhibiting D-hydrogenases in the complex mixture of enzymes found in baker’s yeast. Other halo ester additives were investigated.

There is still a lot of research devoted to this compound(SMILES：O=C(OCC)C[C@@H](O)CCl)Computed Properties of C6H11ClO3, and with the development of science, more effects of this compound(90866-33-4) can be discovered.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Product Details of 90866-33-4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Production of (R)-ethyl-4-chloro-3-hydroxybutanoate using Saccharomyces cerevisiae YOL151W reductase immobilized onto magnetic microparticles. Author is Choo, Jin Woo; Kim, Hyung Kwoun.

For the synthesis of various pharmaceuticals, chiral alcs. are useful intermediates. Among them, (R)-ethyl-4-chloro-3-hydroxybutanoate ((R)-ECHB) is an important building block for the synthesis of L-carnitine. (R)-ECHB is produced from ethyl-4-chloro-3-oxobutanoate (ECOB) by a reductase-mediated, enantioselective reduction reaction. The Saccharomyces cerevisiae YOL151W reductase that is expressed in Escherichia coli cells exhibited an enantioselective reduction reaction toward ECOB. By virtue of the C-terminal His-tag, the YOL151W reductase was purified from the cell-free extract using Ni2+-NTA column chromatog. and immobilized onto Ni2+-magnetic microparticles. The phys. properties of the immobilized reductase (Imm-Red) were measured using electron microscopy, a magnetic property measurement system, and a zeta potential system; the average size of the particles was approx. 1 μm and the saturated magnetic value was 31.76 emu/g. A neodymium magnet was used to recover the immobilized enzyme within 2 min. The Imm-Red showed an optimum temperature at 45°C and an optimum pH at 6.0. In addition, Bacillus megaterium glucose dehydrogenase (GDH) was produced in the E. coli cells and was used in the coupling reaction to regenerate the NADPH cofactor. The reduction/oxidation coupling reaction composed of the Imm-Red and GDH converted 20 mM ECOB exclusively into (R)- ECHB with an e.e.p value of 98%.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Name: (R)-Ethyl 4-chloro-3-hydroxybutanoate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Escherichia coli transformant expressing the glucose dehydrogenase gene from Bacillus megaterium as a cofactor regenerator in a chiral alcohol production system. Author is Kataoka, Michihiko; Rohani, Luh Poni Sri; Wada, Masaru; Kita, Keiko; Yanase, Hideshi; Urabe, Itaru; Shimizu, Sakayu.

Escherichia coli JM109 (pGDA2) overexpressing the glucose dehydrogenase (GDH) gene from Bacillus megaterium IWG3 was examined for use as a cofactor regenerator. In the asym. reduction of Et 4-chloro-3-oxobutanoate by E. coli JM109 (pKAR) which is an aldehyde reductase-overproducing transformant, E. coli JM109 (pGDA2) can act as an NADPH regenerator with NADP+ and glucose, similarly to com. available GDH.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Recommanded Product: 90866-33-4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Asymmetric synthesis of (+)-negamycin. Author is Davies, Stephen G.; Ichihara, Osamu.

(+)-Negamycin was synthesized employing the highly diastereoselective conjugate addition of lithium (α-methylbenzyl)benzylamide in the key step. The synthesis was completed in 13 steps starting from Et 4-chloroacetoacetate with an overall yield of 24%.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Fluoronicotinonitrile, is researched, Molecular C6H3FN2, CAS is 3939-12-6, about Concise Synthesis of Furo[2,3-b]indolines via [3,3]-Sigmatropic Rearrangement of N-Alkenyloxyindoles, the main research direction is furoindoline preparation; alkenyloxyindole sigmatropic rearrangement.Quality Control of 6-Fluoronicotinonitrile.

A concise new synthetic route to furo[2,3-b]indolines has been developed by taking advantage of the reactivity of N-alkenyloxyindole intermediates. These compounds spontaneously underwent [3,3]-sigmatropic rearrangement followed by cyclization to form hemiaminals as single diastereomers. Tin-promoted N-hydroxyindole formation followed by conjugate addition to activated alkynes provides simple and modular access to a diverse array of N-alkenyloxyindoles and their corresponding furo[2,3-b]indolines. Microscale high-throughput experimentation was used to facilitate investigation of the scope and tolerance of this transformation and related studies on the nucleophilic aromatic substitution and rearrangement of N-hydroxyindoles with halogenated arenes have also been evaluated.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

1646-26-0, 2-Acetylbenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of acetophenone (100 mg, 1 equiv) or phenylacetylene (1 equiv) in dioxane (5 mL), Oxone (2 equiv) and TFA (2 equiv) were added. The mixture was then heated to reflux for 10 h and then cooled to r.t. H2O (10 mL) was added and the mixture was extracted with EtOAc (2 × 20 mL). The combined organic layers were treated with sat. NaHCO3 solution and the aqueous layer was poured onto crushed ice and treated with 2 M HCl; a colorless solid precipitated out. The precipitate was filtered off and dried in vacuo to give benzoic acid (3a) after column chromatography (silica gel; EtOAc-hexane, 1:9) as a white crystalline solid; yield: 0.096 g (95%) from 1a; mp 122-123 C.

1646-26-0, 1646-26-0 2-Acetylbenzofuran 15435, abenzofuran compound, is more and more widely used in various fields.

Reference：
Article; Aravinda Kumar; Venkateswarlu, Vunnam; Vishwakarma, Ram A.; Sawant, Sanghapal D.; Synthesis; vol. 47; 20; (2015); p. 3161 – 3168;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.374706-07-7,1-(2,3-Dihydrobenzofuran-6-yl)ethanone,as a common compound, the synthetic route is as follows.

2-Bromo-l-(2,3-dihydro-benzofuran-6-yl)-ethanoneBr2 (0.36 ml, 7.01 mmol) was added dropwise to a stirring solution of l-(2,3-dihydro- benzofuran-6-yl)-ethanone (1.13 g, 6.97 mmol) in MeOH (20 mL) held at 00C. The reaction mixture was slowly allowed to reach room temperature. After 3 h, the reaction was quenched by the addition of NaHCO3 (aq, saturated)(until pH=8). Most of the methanol was removed under reduced pressure and the residue was extracted twice with EtOAc (2×20 mL). The organic extracts were pooled, washed with brine (10 mL), dried over MgSO4 and concentrated under reduced pressure. The residue was purified by preparative HPLC using a gradient of 40-70% MeCN in a 0.1M ammonium acetate buffer as eluent. The fractions containing the desired product were pooled and most of the MeCN was removed under EPO reduced pressure. The residue was extracted with EtOAc (2×20 mL) and the combined organic layers was washed with brine, dried over MgSO4 and concentrated. The obtained was finely washed MeOH to give the title compound.1H-NMR (CDC13, 400 MHz): delta 3.25 (t, 2H), 4.39 (s, 2H), 4.61 (t, 2H), 7.24-7.36 (m, 2H), 7.45-7.52 (m, IH).-, 374706-07-7

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Reference：
Patent; ASTRAZENECA AB; WO2006/137796; (2006); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

23405-32-5, Methyl 1-oxo-1,3-dihydroisobenzofuran-5-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 2 was converted to 1,3-dihydro-1-oxoisobenzofuran-5-carbohydrazide (3) by reacting with hydrazine hydrate in methanol. To a mixture of methyl-1,3-dihydro-1-oxoisobenzofuran-5-carboxylate (2, 5.2 mmol) and methanol (5 mL) at 20-25 C, hydrazine hydrate (5 mL) was added. The reaction mass was refluxed for 4 h and the reaction completion was monitored by TLC. The reaction mass was filtered, washed with water followed by methanol and finally dried to get the pure product. White colour solid, yield: 98 %, m.p.: 220-230 C. IR (KBr, numax, cm-1): 3284 (-NH), 3178 (-NH2), 3053 (-CH), 1759 (lactone C=O), 1644 (amide C=O), 1045 (C-O); 1H NMR (400 MHz, DMSO-d6) delta ppm: 5.44 (2H, d, CH2), 7.41 (1H, m, ArH), 7.72 (1H, m, ArH), 8.01 (1H, dd, ArH), 9.81 (1H, s, CONH), 4.50 (2H, -NH2); 13C NMR (100 MHz, DMSO-d6) delta ppm: 170.2, 164.5, 144.8, 134.8, 128.7, 127.6, 126.4, 123.8, 60.6. LC-MS: m/z: 192 [M]+, 193 [M+1]+. Elemental analysis of C9H8N2O3 calcd. (found) %: C, 56.28 (56.23); H, 4.20 (4.20); N, 14.58 (14.58); O, 24.98 (24.99)., 23405-32-5

As the paragraph descriping shows that 23405-32-5 is playing an increasingly important role.

Reference：
Article; Rao, Nunna Madhava; Viveka, Tella Lakshmi; Raju, Koneti Mallikarjuna; Chary, Maringanti Thirumala; Asian Journal of Chemistry; vol. 32; 1; (2020); p. 95 – 100;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

1646-26-0, 2-Acetylbenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of acetophenone (100 mg, 1 equiv) or phenylacetylene (1 equiv) in dioxane (5 mL), Oxone (2 equiv) and TFA (2 equiv) were added. The mixture was then heated to reflux for 10 h and then cooled to r.t. H2O (10 mL) was added and the mixture was extracted with EtOAc (2 × 20 mL). The combined organic layers were treated with sat. NaHCO3 solution and the aqueous layer was poured onto crushed ice and treated with 2 M HCl; a colorless solid precipitated out. The precipitate was filtered off and dried in vacuo to give benzoic acid (3a) after column chromatography (silica gel; EtOAc-hexane, 1:9) as a white crystalline solid; yield: 0.096 g (95%) from 1a; mp 122-123 C.

1646-26-0, 1646-26-0 2-Acetylbenzofuran 15435, abenzofuran compound, is more and more widely used in various fields.

Reference：
Article; Aravinda Kumar; Venkateswarlu, Vunnam; Vishwakarma, Ram A.; Sawant, Sanghapal D.; Synthesis; vol. 47; 20; (2015); p. 3161 – 3168;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem