With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23681-89-2,2,3-Dihydrobenzofuran-6-ol,as a common compound, the synthetic route is as follows.
EXAMPLE 25 875 mg. of a 55percent by weight sodium hydride dispersion in oil are washed three times with absolute tetrahydrofuran and then covered with 10 ml. of absolute tetrahydrofuran. Thereafter, the mixture is treated at 0¡ã C. and while stirring with a solution of 2.72 g. of 6-hydroxy-2,3-dihydrobenzofuran in 12 ml. of absolute tetrahydrofuran. The mixture is stirred for one hour (during which time it is allowed to warm up to room temperature), then again cooled to 0¡ã C. and added dropwise to a solution of 1-bromo-7-ethoxy-3,7-dimethyl-2-octene in 12 ml. of absolute tetrahydrofuran. 12 ml. of pure hexamethylphosphoric acid triamide are then added to the mixture, the ice bath is removed and the mixture stirred for 3 hours. The mixture is worked up by pouring it onto ice-water and extracting the resulting mixture three times with diethyl ether. The extracts are washed with water and saturated aqueous sodium chloride solution, dried over sodium sulfate and evaporated. By chromatography on silica gel with hexane/diethyl ether (19:1 parts by volume) there is obtained pure 6-[(7-ethoxy-3,7-dimethyl-2-octenyl)-oxy]-2,3-dihydrobenzofuran which is distilled in a bulb-tube at 150¡ã C./0.05 mmHg; nD20.5 = 1.5172.
23681-89-2 2,3-Dihydrobenzofuran-6-ol 12236540, abenzofuran compound, is more and more widely used in various.
Reference£º
Patent; Hoffmann-La Roche Inc.; US4002647; (1977); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem