Tag: 200-300

In 2022,Geng, Xiaorui; Chen, Yuhao; Chen, Zhiyi; Wei, Xianyuan; Dai, Yunlu; Yuan, Zhen published an article in Ultrasonics Sonochemistry. The title of the article was 《Oxygen-carrying biomimetic nanoplatform for sonodynamic killing of bacteria and treatment of infection diseases》.Recommanded Product: 5471-63-6 The author mentioned the following in the article:

Among various novel antimicrobial therapies, sonodynamic therapy (SDT) exhibits its advantages for the treatment of bacterial infections due to its high penetration depth and low side effects. In this study, a new nanosonosensitizer (HFH@ZIF-8) that loads sonosensitizer hematoporphyrin monomethyl ether (HMME) into zeolitic imidazolate framework-8 (ZIF-8), was constructed for killing multidrug-resistant (MDR) bacteria and treatment of in vivo infection diseases by SDT. In particular, the developed HFH@ZIF-8 exhibited enhanced water-solubility, good biocompatibility, and improved disease-targeting capability for delivering and releasing HMME and ablating the infected lesion. More importantly, the presence of oxygen-carrying Hb for HFH@ZIF-8 can offer sufficient oxygen consumption by SDT, augmenting the efficacy of SDT by improving ROS generating efficiency against deep tissue multidrug-resistant bacterial infection. Therefore, this study paves a new avenue for treating infection disease, particularly for antibiotic resistant bacterial infection. The experimental process involved the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Recommanded Product: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Assemblies of indocyanine green and chemotherapeutic drug to cure established tumors by synergistic chemo-photo therapy》 was published in Journal of Controlled Release in 2020. These research results belong to Hu, Shiqi; Dong, Chengyuan; Wang, Jinqiang; Liu, Kexin; Zhou, Quan; Xiang, Jiajia; Zhou, Zhuxian; Liu, Fusheng; Shen, Youqing. COA of Formula: C20H14O The article mentions the following:

Indocyanine green (ICG), a safe and clin. approved near-IR (NIR) dye, was recently explored as a potential photosensitizer due to its excellent photophys. properties. However, ICG tends to form aggregations in physiol. solution, causing fluorescence quenching, fast blood clearance and thereby inefficient tumor accumulation. Herein, we report ICG-based nanodrug delivery systems formed by self-assembly of ICG and chemotherapeutic drugs without any excipients for combined chemo- and photo-therapy. Taking advantage of the amphiphilic aromatic structure, ICG readily bounded with hydrophobic aromatic drugs such as SN38 and formed well-dispersible nanoparticles, which reduced its aggregation-induced quenching and thus greatly improved its photodynamic efficiency. The loaded hydrophobic drugs elicited chemotherapy synergizing the photodynamic therapy, giving rise to much enhanced antitumor activity in vitro and in vivo against human glioblastoma cells and breast cancer cells upon NIR irradiation The work demonstrates the fabrication of readily translational nanoformulations of hydrophobic drugs using amphiphilic drugs. In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6COA of Formula: C20H14O) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.COA of Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In 2022,Deng, Yi; Shi, Jiacheng; Chan, Yau Kei; Bai, Ding; Shu, Rui; Shi, Xiuyuan; Li, Yunfei; Li, Limei; Yang, Xiao; Yang, Weizhong published an article in Advanced Healthcare Materials. The title of the article was 《Heterostructured Metal-Organic Frameworks/Polydopamine Coating Endows Polyetheretherketone Implants with Multimodal Osteogenicity and Photoswitchable Disinfection》.Recommanded Product: 5471-63-6 The author mentioned the following in the article:

Clin., bacteria-induced contagion and insufficient osseointegrative property inevitably elicit the failure of orthopedic implants. Herein, a heterostructured coating consisting of simvastatin (SIM)-laden metal-organic frameworks and polydopamine nanolayers is created on a porous bioinert polyetheretherketone implant. The heterostructured coating significantly promotes cytocompatibility and osteogenic differentiation through multimodal osteogenicity mechanisms of zinc ion (Zn2+) therapy, SIM drug therapy, and surface micro-/nano-topol. stimulation. Under the illumination of near-IR (NIR) light, singlet oxygen (1O2) and local hyperthermia are produced; besides, NIR light dramatically accelerates the release of Zn2+ ions from heterostructured coatings. Gram-pos. and -neg. bacteria are effectively eradicated by the synergy of photothermal/photodynamic effects and photo-induced accelerated delivery of Zn2+ ions. The superior osteogenicity and osseointegration, as well as photoswitchable disinfection controlled by NIR light are corroborated via in vivo results. This work highlights the great potential of photoresponsive heterostructured orthopedic implants in treatment of the noninvasive bone reconstruction of bacteria-associated infectious tissues through multimodal phototherapy and photoswitchable ion-therapy. In the part of experimental materials, we found many familiar compounds, such as 1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Recommanded Product: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Nanostructured lipid carrier delivering chlorins e6 as in situ dendritic cell vaccine for immunotherapy of gastric cancer》 was published in Journal of Materials Research in 2020. These research results belong to Mao, Mao; Liu, Senfeng; Zhou, Yiming; Wang, Gonghe; Deng, Jianping; Tian, Lei. Category: benzofurans The article mentions the following:

The recent scientific progress has shown the promising effect of the vaccine in immunotherapy of cancer, which relies on the antigen processing/presentation capability of dendritic cells (DCs). As a result, cancer vaccines targeting DC, which also named as DC vaccine, was a hot-spot in vaccine development. Herein, a nanostructured lipid carrier (NLC) was employed to load chlorin e6 (Ce6) to serve as a potential in situ DC vaccine (NLC/Ce6) for effective immunotherapy of gastric cancer. Taking advantage of the photodynamic effect of Ce6 to generate reactive oxygen species (ROS) under laser irradiation, the NLC/Ce6 was able to trigger cell death and expose tumor-associated antigen (TAA). Moreover, mimicking the natural inflammatory response, the ROS can also recruit the DC for the effective processing/presentation of the in situ exposed TAA. As expected, we observed strong capability DC vaccination efficacy of this platform to effectively inhibit the growth of both primary and distant gastric tumors. In the experimental materials used by the author, we found 1,3-Diphenylisobenzofuran(cas: 5471-63-6Category: benzofurans)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Godoy, Agustin A.; Bernini, Maria C.; Funes, Matias D.; Sortino, Maximiliano; Collins, Sebastian E.; Narda, Griselda E. published their research in Dalton Transactions in 2021. The article was titled 《ROS-generating rare-earth coordination networks for photodynamic inactivation of Candida albicans》.SDS of cas: 5471-63-6 The article contains the following contents:

Water-ethanol suspensions of 2D coordination network (CN) based on rare earth elements and mixed ligands were evaluated as reactive oxygen species (ROS) generators under UV light irradiation, in contact with a biomimetic substrate (tryptophan) or an O2(1Δg) quencher (1,3-diphenylisobenzofuran; 1,3-DPBF). A combination of bottom-up and top-down strategies was implemented in order to obtain nano-sized CN particles and the subsequent colloidal suspensions were also tested towards photodynamic inactivation of Candida albicans (C. albicans). SEM, TEM, FTIR, and XRD techniques were applied to characterize the solids and ICP-AES was employed to determine the metal content of the colloidal suspensions. Promising results were found indicating that the presence of Tb3+ allows an intersystem crossing suitable for singlet oxygen generation, resulting in the antifungal activity of C. albicans culture upon UV-irradiation1,3-Diphenylisobenzofuran(cas: 5471-63-6SDS of cas: 5471-63-6) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.SDS of cas: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

SDS of cas: 5471-63-6In 2020 ,《A strategy for monitoring oxygen concentration, oxygen consumption, and generation of singlet oxygen using a phosphorescent photosensitizer》 was published in Journal of Luminescence. The article was written by Zang, Lixin; Zhao, Huimin. The article contains the following contents:

Monitoring oxygen concentration ([O2]), oxygen consumption, and generation of singlet oxygen (1O2) is critical in photodynamic therapy (PDT) used for the precise treatment of cancer. To this end, a strategy based on a phosphorescent photosensitizer, gadolinium-hematoporphyrin monomethyl ether (Gd-HMME), was developed for monitoring [O2] in this study. Diphenylisobenzofuran (DPBF) was used to consume 1O2 produced by the Gd-HMME-mediated PDT. A sealed system comprising Gd-HMME and DPBF under irradiation was designed to simulate PDT when tissue oxygen was insufficient. Upon irradiation by a 532-nm laser, Gd-HMME phosphorescence initially increased rapidly, reached a maximum, and remained unchanged thereafter, because oxygen in the system was exhausted. The increase in phosphorescence increased with increasing fluence rates, suggesting that the change in phosphorescence was related to oxygen consumption. The depletion of DPBF in the system indicated the generation of 1O2 and a reaction between DPBF and 1O2. The phosphorescence decreased rapidly when the system was re-exposed to air. In contrast, the change in the phosphorescence intensity in an open cuvette was minimal and could be neglected. Thus, [O2] and generation of 1O2 in PDT could be monitored using the phosphorescence intensity of the photosensitizer, based on the dependence of phosphorescence and singlet oxygen quantum yield on [O2]. In the part of experimental materials, we found many familiar compounds, such as 1,3-Diphenylisobenzofuran(cas: 5471-63-6SDS of cas: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.SDS of cas: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application of 5471-63-6In 2022 ,《Preparation of a porphyrin-polyoxometalate hybrid and its photocatalytic degradation performance for mustard gas simulant 2-chloroethyl ethyl sulfide》 appeared in Chinese Chemical Letters. The author of the article were Yang, Ying; Tao, Fangsheng; Zhang, Lijuan; Zhou, Yunshan; Zhong, Yuxu; Tian, Shubo; Wang, Yong′an. The article conveys some information:

By combining 5,10,15,20-tetra(4-chlorine)phenylporphyrin (TClPP) and α-Keggin polyoxometalate H5PV2Mo10O40 (H5PVMo) via a simple ion-exchange method, an organic-inorganic hybrid material [C44H28N4Cl4]1.5[H2PMo10V2O40]·2C2H6O (H2TClPP-H2PVMo) was prepared and thoroughly characterized by a variety of techniques. The homogeneous photocatalytic degradation of 2-chloroethyl Et sulfide (CEES) (5 μL) by H2TClPP-H2PVMo (1 x 10-6 mol/L) was studied in methanol and methanol-water mixed solvent (volume/volume = 1:1), in which the degradation rate of CEES reached 99.52% and 99.14%, resp. The reaction followed first-order reaction kinetics, and the half-life and kinetic constant in methanol and the mixed solvent were resp. 33.0 min, -0.021 min-1 and 15.7 min, -0.043 min-1. Mechanism anal. indicated that under visible light irradiation in the air, CEES was degraded via oxidation and alcoholysis/hydrolysis in methanol and the mixed solvent. O2·- and 1O2 generated by H2TClPP-H2PVMo selectively oxidized CEES into a nontoxic sulfoxide. Singlet oxygen capture experiments showed that H2TClPP-H2PVMo (θ= 0.73) had a higher quantum yield of singlet oxygen than TClPP (θ= 0.35) under an air atm. and visible light irradiation In the experiment, the researchers used many compounds, for example, 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Application of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Safety of 1,3-DiphenylisobenzofuranIn 2022 ,《Singlet oxygen formation from photoexcited P3HT:PCBM films applied in oxidation reactions》 appeared in Materials Advances. The author of the article were Nyga, Aleksandra; Blacha-Grzechnik, Agata; Podsiadly, Przemyslaw; Duda, Alicja; Kepska, Kinga; Krzywiecki, Maciej; Motyka, Radoslaw; Janssen, Rene A. J.; Data, Przemyslaw. The article conveys some information:

Poly(3-hexylthiophene) thin films containing carbon-based nanostructures, i.e. fullerenes such as buckminsterfullerene (C60) or phenyl-C61-butyric acid Me ester (PCBM), or single-walled carbon nanotubes, were investigated as heterogeneous photosensitizers producing singlet oxygen (1O2) in aerated organic solvents. Thin films were deposited on borosilicate glass using spin coating and characterized by profilometry, UV-vis, Raman and XPS. Photogeneration of 1O2 was confirmed by photooxidation of 1,3-diphenylisobenzofuran and by reaction of 1,5-dihydroxynaphthalene to juglone. The photochem. efficiency of the blends was found to depend on the carbon-based photosensitizer and can be increased by varying its concentration in the poly(3-hexylthiophene) matrix. After reading the article, we found that the author used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Safety of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Safety of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In 2022,Wang, Zirui; Song, Qiusheng; Zhu, Lin; Zhao, Chengyan; Ma, Haihong published an article in Journal of Fluorescence. The title of the article was 《Synthesis, Characterization of NR@SiO2/PNIPAm-co-Ppa Composite Nanogel and Study On Its Application in Photodynamic Therapy》.Electric Literature of C20H14O The author mentioned the following in the article:

In the present study, a novel composite nanogel based on fluorescence resonance energy transfer (FRET) and its application for photodynamic therapy is reported. First of all, nanoparticles of silica doped with Nile Red (NR) were prepared by Stober method, then they were decorated by γ-methacryloxypropyltrimethoxysilane (MPS) to prepare MPS decorated NR@SiO2 nanoparticles, and finally they were copolymerized with N-isopropylacrylamide (NIPAm) and Pyropheophorbide-a (Ppa) by free radical copolymerization, and composite nanogel of NR@SiO2/PNIPAm-co-Ppa was fabricated. The microstructure of the as-prepared nanogel was characterized by Fourier transform IR spectrum (FTIR), photoluminescence (PL), UV-Visible spectrophotometer (UV-Vis), dynamic light scattering (DLS) and transmission electron microscopy (TEM). PL spectrum indicated that, under irradiation of visible light source, energy can be transferred from NR to Ppa. UV-Vis spectrum demonstrated that aggregation of Ppa is prevented efficiently and Ppa exists as “”monomer”” state in the composite nanogel. Under irradiation of laser, singlet oxygen (1O2) can be produced efficiently by excited nanogel. The in vitro cytotoxicity test showed that HeLa cells can be killed by the composite nanogel. In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Electric Literature of C20H14O) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Electric Literature of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cheng, Jianjun; Wang, Shu; Zhao, Haitian; Liu, Yan; Yang, Xin published an article in 2021. The article was titled 《Exploring the self-assembly mechanism and effective synergistic antitumor chemophototherapy of a biodegradable and glutathione responsive ursolic acid prodrug mediated photosensitive nanodrug》, and you may find the article in Biomaterials Science.Application In Synthesis of 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:

Supermolecularly assembled photochemotherapeutic nanocomposites composed of pure drug small mols. are promising for synergistically improved tumor therapy, yet potential multiple challenges remain to be addressed. Herein, we rationally designed a novel multifunctional small mol. disulfide modified natural pentacyclic triterpene of ursolic acid (UASS) that simultaneously possesses self-assembly ability, glutathione (GSH) responsivity, anticancer activity, biocompatibility and biodegradability and further constructed carrier-free GSH-sensitive photosensitive nanocomposite UASS-Ce6 NPs for safe and synergistically improved chemophototherapy. Specifically, UASS-Ce6 NPs exhibit improved 1 O2 generation by reducing the energy gap (ΔEST) of Ce6 as determined by d. functional theory. Meanwhile, mol. dynamics simulation revealed the possible reasons why free UASS self-assembles and UASS-Ce6 NPs with different assembled morphologies may be primarily attributed to the coplanar arrangement of UASS dimer units. Importantly, via noncovalent π-stacking and hydrophobic interactions, the resulting co-assemblies showed improved water solubility, increased intercellular ROS generation, desirable GSH sensibility, excellent biocompatibility, and enhanced tumor accumulation accompanied by rapid biodegradation, thus leading to significant in vitro and in vivo synergistic antitumor efficacy with favorable biosafety. This study provides a promising insight into the development of a self-assembled active single component platform with desirable stimuli responsiveness and biosafety toward synergistic antitumor therapy based on terpenoid natural small mols. In the experimental materials used by the author, we found 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application In Synthesis of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Application In Synthesis of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem