Tag: 200-300

A feasible fluorimetric approach anchored in diaryl pyrrolone derivative for the facile analysis of milnacipran in tablets; evaluation of the method greenness was written by Derayea, Sayed M.;Madian, Hoda;Samir, Ebtihal;Hamad, Ahmed A.;Badr El-Din, Khaled M.. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2022.Recommanded Product: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

In the present work a new, feasible, and green approach was employed for the anal. of milnacipran. A drug is used in the management of depression in addition to fibromyalgia. It inhibits of the reuptake of two essential neurotransmitters serotonin and nor-adrenaline. In slightly alk. buffer (pH 8.5) the primary amino group of milnacipran reacted with fluorescamine to give a substituted pyrrolone derivative which exhibited high fluorescence activity. The fluorescence of produced derivative was measured at (λ_ex 385 nm, λ_em 477 nm), and the exptl. factors were cautiously optimized. The measured intensity of fluorescence was plotted vs. the resp. concentration of milnacipran to setup the calibration plot which has a linear concentration range of 50-300 ng/mL. The ICH guidelines were utilized to totally validate the presented approach. In addition the method could be efficiently incorporated in the anal. of com. milnacipram tablets with no considerable effect on the results of the assay for milnacipran. The developed approach is characterized by its high simplicity and greenness of the procedure which make it suitable for routine anal. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Recommanded Product: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Recommanded Product: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Reaction with hydrazonoyl halides 64: Synthesis of some new triazolino[4,3-a]pyrimidines, 1,3,4-thiadiazoles, and 5-arylazothiazoles was written by Abdelhamid, Abdou O.;Fahmi, Abdelgawad A.;Baaui, Basma S.. And the article was included in Journal of Heterocyclic Chemistry in 2012.Formula: C10H7BrO2 This article mentions the following:

2,3-Dihydro-1,3,4-thiadiazoles, 2,3-dihydro-1,3,4-selenadiazoles, and triazolino[4,3-a]pyrimidines containing a benzofuran moiety were prepared from the reaction of 2-(2-phenylhydrazono)-1-(5-bromobenzofuran-2-yl)-2-chloroethanone with KSCN, KSeCN, alkyl carbodithioates, and pyrimidine-2-thiones, resp. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Formula: C10H7BrO2).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Formula: C10H7BrO2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Mix-and-Match Assembly of Block Copolymer Blends in Solution was written by Cho, Arah;La, Yunju;Jeoung, Sungeun;Moon, Hoi Ri;Ryu, Ja-Hyoung;Shin, Tae Joo;Kim, Kyoung Taek. And the article was included in Macromolecules (Washington, DC, United States) in 2017.Product Details of 38183-12-9 This article mentions the following:

The chem. structure of a block copolymer (BCP) dictates the size, shape, and function of its self-assembled structure in solution This direct correspondence demands precision synthesis of a specific BCP with optimized structural parameters to obtain the desired nanostructures with structural and functional complexity by solution self-assembly. Here we show that the binary blends of BCPs self-assemble into the desired nanostructure in solution by adjusting the composition of the blend. By modifying the structural parameters of a binary BCP blend through control of the composition, two BCPs sharing the repeating units in both polymer blocks coassemble into the desired structures, which range from spherical micelles to inverse cubic and hexagonal mesophases. These BCP blends not only allow the direct creation of complex periodic mesoporous structures of the desired periodicity and pore size but also provide nanostructures of unprecedented morphol. by simple solution self-assembly without relying on the synthesis of correspondingly designed BCPs. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Product Details of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Product Details of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Alternative sample treatments for the determination of sulfonamides in milk by HPLC with fluorescence detection was written by Arroyo-Manzanares, Natalia;Gamiz-Gracia, Laura;Garcia-Campana, Ana M.. And the article was included in Food Chemistry in 2014.Synthetic Route of C17H10O4 This article mentions the following:

Sample treatments by dispersive liquid-liquid microextraction (DLLME) and QuEChERS for the determination of 9 sulfonamides in milk were compared. Both sample preparation methods represent useful alternatives to conventional procedures based mainly on solid-phase extraction, in terms of simplicity, decreased use of organic solvents, sample throughput, and effectiveness in extract clean-up. The sample preparation methods were compared for efficiency, trueness, sensitivity and precision using HPLC with fluorescamine derivatization and fluorescence detection. The clean extracts were obtained with analyte recoveries 90.8-104.7 and 83.6-104.8% for DLLME and QuEChERS, resp. Matrix-matched calibration curves were established for both methods using milk samples spiked at 4 concentration levels. LODs (3xS/N) <1.21 and 2.73 μg/L for DLLME and QuEChERS, resp., were obtained in all cases. The precision, in terms of repeatability and intermediate precision, was <10% in all cases. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Synthetic Route of C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Synthetic Route of C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Determination of ten sulfonamides in honey using tetrahydrofuran Salting Out Liquid Liquid Extraction and monolithic silica column was written by Kadzinski, Leszek;Banasiuk, Rafal;Banecki, Bogdan. And the article was included in LWT–Food Science and Technology in 2018.Formula: C17H10O4 This article mentions the following:

This study presented a novel extraction method using acid hydrolysis and salting out liquid-liquid extraction (SALLE) using THF without the need of the cleanup or sample evaporation step, and a simple HPLC-fluorescence method with pre-column derivatization using a reverse phase C18 monolith column for detection of 10 sulfonamides in honey. Different sulfonamides such as sulfathiazole, sulfamethazine, sulfamerazine, sulfanilamide, sulfamethoxypyridazine, sulfachloropyridazine, sulfacetamide, sulfamethoxazole, sulfadimethoxine and sulfadiazine were extracted from wildflower honey samples by salting out liquid-liquid extraction with THF. Stability of derivatized sulfonamide samples were detected in different solvents like THF, methanol and citrate buffer pH 3.5. HPLC-fluorescence method developed using monolithic silica column demonstrated to be specific, because no interfering peaks were observed at the retention time of sulfonamide analytes. The author concluded that the SALLE extraction and HPLC-fluorescence method developed in this study was specific, accurate and precise over a linear dynamic range for detecting sulfonamides in honey samples. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A new cyano-substituted fluorescamine superior to its original form as a fluorescent probe for amino acid detection was written by Motoyoshiya, Jiro;Tomioka, Satoshi;Kobayashi, Daigo;Fujimoto, Tetsuya. And the article was included in Tetrahedron Letters in 2018.Synthetic Route of C17H10O4 This article mentions the following:

Synthesis and spectral study of two new cyano-substituted fluorescamine as the fluorescent probes for amino acid detection have been carried out comparing with the original fluorescamine. Of the three compounds, the derivative with a cyano group at the meta-position on the 4-Ph group was superior to the original one in the reactivity toward some amino acids as well as the fluorescence intensity of the adducts. The fluorescent amino acid adducts were also applied to the peroxyoxalate chemiluminescence system as the fluorophores, in which the derivative described above was more effective also in chemiluminescence than the original one. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Synthetic Route of C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Synthetic Route of C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

1-(5-Bromo-1-benzofuran-2-yl)ethanone was written by Fun, Hoong-Kun;Quah, Ching Kheng;Abdel-Aziz, Hatem A.. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2012.Related Products of 38220-75-6 This article mentions the following:

The title compound, C₁₀H₇BrO₂, is approx. planar (r.m.s. deviation = 0.057 Å for the 13 non-H atoms). In the crystal, mols. are linked via C-H···O hydrogen bonds into C(5) chains propagating in [100]. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Related Products of 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Related Products of 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Quinoxalines. Part 13: Synthesis and mass spectrometric study of aryloxymethylquinoxalines and benzo[b]furylquinoxalines was written by Starke, Ines;Sarodnick, Gerhard;Ovcharenko, Vladimir V.;Pihlaja, Kalevi;Kleinpeter, Erich. And the article was included in Tetrahedron in 2004.COA of Formula: C10H7BrO2 This article mentions the following:

A series of new aryloxymethylquinoxalines, benzo[b]- and naphtho[2,1-b]furylquinoxalines, possessing potential biol. activity, was prepared, characterized by IR and NMR spectroscopy and their electron ionization (EI) mass spectra studied in detail. The aryloxymethylquinoxalines were obtained by reacting halogenomethylquinoxalines with bifunctional O-nucleophiles. The benzo[b]furylquinoxalines and naphtho[2,1-b]furylquinoxalines were prepared via two routes, which differed in the order of the two cyclization steps involved in the syntheses. The composition of the ions obtained by EI mass spectrometry were determined by accurate mass measurements and the fragmentation pathways clarified by B/E linked scans and collision induced dissociation The mass spectrometric behavior of the compounds studied as to the possible loss of OH^• radicals proved to be very characteristic. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6COA of Formula: C10H7BrO2).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.COA of Formula: C10H7BrO2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Development of a dual luciferase activity and fluorescamine protein assay adapted to a 384 micro-well plate format: Reducing variability in human luciferase transactivation cell lines aimed at endocrine active substances was written by Brennan, Jennifer C.;Tillitt, Donald E.. And the article was included in Toxicology In Vitro in 2018.SDS of cas: 38183-12-9 This article mentions the following:

There is a need to adapt cell bioassays to 384-well and 1536-well formats instead of the traditional 96-well format as high-throughput screening (HTS) demands increase. However, the sensitivity and performance of the bioassay must be re-verified in these higher micro-well plates, and verification of cell health must also be HT (high-throughput). We have adapted two commonly used human breast luciferase transactivation cell bioassays, the recently re-named estrogen agonist/antagonist screening VM7Luc4E2 cell bioassay (previously designated BG1Luc4E2) and the androgen/glucocorticoid screening MDA-kb2 cell bioassay, to 384-well formats for HTS of endocrine-active substances (EASs). This cost-saving adaptation includes a fast, accurate, and easy measurement of protein amount in each well via the fluorescamine assay with which to normalize luciferase activity of cell lysates without requiring any transfer of the cell lysates. Here we demonstrate that by accounting for protein amount in the cell lysates, antagonistic agents can easily be distinguished from cytotoxic agents in the MDA-kb2 and VM7Luc4E2 cell bioassays. Addnl., we demonstrate via the fluorescamine assay improved interpretation of luciferase activity in wells along the edge of the plate (the so-called “edge effect”), thereby increasing usable wells to the entire plate, not just interior wells. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9SDS of cas: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.SDS of cas: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rapid and selective determination of multi-sulfonamides by high-performance thin layer chromatography coupled to fluorescent densitometry and electrospray ionization mass detection was written by Chen, Yisheng;Schwack, Wolfgang. And the article was included in Journal of Chromatography A in 2014.COA of Formula: C17H10O4 This article mentions the following:

Sulfonamides are widely used in animal husbandry and monitoring their residues in edible animal tissues is important for food safety and quality control. A simple and efficient high-performance thin-layer chromatog. (HPTLC) anal. method for rapid screening of 12 veterinary sulfonamide drugs was developed. Sample acetonitrile extracts were 10-fold concentrated and applied to HPTLC without any further cleanup. Following separation and fluram derivatization, sensitive and selective quantitation of the analytes was readily accomplished with fluorescence densitometry. Limits of detection and quantitation were 15-40 and 35-70 μg/kg, resp. Confirmative detection by HPTLC-electrospray ionization mass spectrometry (HPTLC-ESI/MS) was optimized for straightforward identification of target TLC zones to decrease the risk of potential false pos. findings. The method was validated for different matrix complexities (cow milk, pork liver and kidney). In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9COA of Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.COA of Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem