Tag: 200-300

HPLC-DAD-FLD Determination of Veterinary Pharmaceuticals in Pharmaceutical Industry Wastewater with Precolumn Derivatization Using Fluorescamine was written by Asperger, Danijela;Tisler, Vesna;Zrncic, Mirta;Mutavdzic Pavlovic, Dragana;Babic, Sandra;Horvat, Alka J. M.;Kastelan-Macan, Marija. And the article was included in Chromatographia in 2014.Recommanded Product: 38183-12-9 This article mentions the following:

A simple and robust method suitable for routine anal. of pharmaceuticals from different classes in pharmaceutical industry wastewater samples is presented. Seven veterinary pharmaceuticals (antibiotics and anesthetic) were simultaneously isolated from a highly complex wastewater matrix. Target compounds were 3 sulfonamide antibiotics (sulfaguanidine, sulfadiazine, and sulfamethazine), 3 fluoroquinolone antibiotics (ciprofloxacin, enrofloxacin, norfloxacin), and one anesthetic, procaine. The investigated compounds were simultaneously pre-concentrated and cleaned up by solid-phase extraction using Strata-X extraction cartridges. The anal. was performed using liquid chromatog. (LC) with diode array and fluorescence detectors connected in series to the chromatog. system. LC separation was performed on a C18 modified column (Phenomenex) with a gradient elution of mobile phase (0.1% acetic acid in water and 0.1% acetic acid in acetonitrile) in 25 min at 30 °C. Recoveries ranged from 86.9 to 110% with relative standard deviations < 10.1 %. Method limits of quantification were in the range of 0.005-0.1 μg L^-1 depending on the fluorescence intensity after precolumn derivatization by fluorescamine. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Recommanded Product: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Recommanded Product: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Photochemical Functionalization of Graphene Oxide by Thiol-Ene Click Chemistry was written by Pineiro-Garcia, Alexis;Vega-Diaz, Sofia M.;Tristan, Ferdinando;Meneses-Rodriguez, David;Labrada-Delgado, Gladis Judith;Semetey, Vincent. And the article was included in Industrial & Engineering Chemistry Research in 2020.Computed Properties of C17H10O4 This article mentions the following:

Graphene oxide (GO) is an important platform that can be functionalized, notably because of its wide variety of functional groups. Functionalization is a critical step, leading to the production of GO-based materials for promising applications in many fields ranging from biomedicine, depollution, to energy storage. Defects introduced into the graphitic domain during graphite oxidation allow to obtain alkene groups, which can be functionalized via thiol-ene click reactions (TER). Usually, for GO functionalization by TER, thermal radical initiators have been used with disadvantages such as high reaction times and the subsequent GO reduction, losing possible oxygen functional groups that can be further used for a second functionalization. Hence, we introduce the photochem. functionalization of GO by TER, with cysteamine as the probe mol., using a photoinitiator. The reaction was characterized by attenuated total reflection-Fourier transform IR spectroscopy, UV spectroscopy, fluorimetry, XPS, and Raman spectroscopy. This new perspective of photoinduced TER provides advantages such as short reaction times, use of mild conditions, and avoiding a subsequent GO reduction, associated with efficient orthogonal functionalization. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Computed Properties of C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Computed Properties of C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Liquid chromatography coupled to on-line post column derivatization for the determination of organic compounds: A review on instrumentation and chemistries was written by Zacharis, Constantinos K.;Tzanavaras, Paraskevas D.. And the article was included in Analytica Chimica Acta in 2013.Electric Literature of C17H10O4 This article mentions the following:

Anal. derivatization either in pre or post column modes is one of the most widely used sample pretreatment techniques coupled to liquid chromatog. In the present review article the authors selected to discuss the post column derivatization mode for the anal. of organic compounds The 1st part of the review focuses to the instrumentation of post-column setups including not only fundamental components such as pumps and reactors but also less common parts such as static mixers and back-pressure regulators; the 2nd part of the article discusses the most popular chemistries that are involved in post column applications, including reagent-less approaches and new sensing platforms such as the popular gold nanoparticles. Some representative recent applications are also presented as tables. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Electric Literature of C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Electric Literature of C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Post column derivatization using reaction flow high performance liquid chromatography columns was written by Jones, Andrew;Pravadali-Cekic, Sercan;Hua, Stanley;Kocic, Danijela;Camenzuli, Michelle;Dennis, Gary;Shalliker, Andrew. And the article was included in Journal of Visualized Experiments in 2016.Reference of 38183-12-9 This article mentions the following:

A protocol for the use of reaction flow high performance liquid chromatog. columns for methods employing post column derivatization (PCD) is presented. A major difficulty in adapting PCD to modern HPLC systems and columns is the need for large volume reaction coils that enable reagent mixing and then the derivatization reaction to take place. This large post column dead volume leads to band broadening, which results in a loss of observed separation efficiency and indeed detection in sensitivity. In reaction flow post column derivatization (RF-PCD) the derivatization reagent(s) are pumped against the flow of mobile phase into either one or two of the outer ports of the reaction flow column where it is mixed with column effluent inside a frit housed within the column end fitting. This technique allows for more efficient mixing of the column effluent and derivatization reagent(s) meaning that the volume of the reaction loops can be minimized or even eliminated altogether. It has been found that RF-PCD methods perform better than conventional PCD methods in terms of observed separation efficiency and signal to noise ratio. A further advantage of RF-PCD techniques is the ability to monitor effluent coming from the central port in its underivatized state. RF-PCD has currently been trialed on a relatively small range of post column reactions, however, there is currently no reason to suggest that RF-PCD could not be adapted to any existing one or two component (as long as both reagents are added at the same time) post column derivatization reaction. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Reference of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Reference of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application of CGE to virus identification was written by Fruetel, Julia A.;Vander Noot, Victoria A.. And the article was included in Methods in Molecular Biology (New York, NY, United States) in 2013.Reference of 38183-12-9 This article mentions the following:

Protein profiling is an increasingly valuable tool for the characterization of protein populations and has been used to identify microorganisms, most often using two-dimensional gel electrophoresis followed by mass spectrometry. We present a rapid method for the identification of viruses using microfluidic chip gel electrophoresis (CGE) of high-copy number proteins to generate unique protein profiles. Viral proteins are solubilized, fluorescently labeled and then analyzed using the μChemLab CGE system (âˆ?0 min overall). A Bayesian classification approach is used to classify the reproducible and visually distinct protein profiles of MS2 bacteriophage, Epstein-Barr, Respiratory Syncytial, and Vaccinia viruses as well as discriminate between closely related T2 and T4 bacteriophage. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Reference of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Reference of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Tube radial distribution phenomenon and its applications: microreactor by taking advantage of kinetic liquid-liquid interface as a chemical reaction space was written by Tsukagoshi, Kazuhiko. And the article was included in Science and Engineering Review of Doshisha University in 2013.Product Details of 38183-12-9 This article mentions the following:

A micro-flow reaction system or microreactor was developed in which a liquid-liquid interface was created based on the tube radial distribution of ternary mixed carrier solvents. The system was constructed from double capillary tubes having different inner diameters (100 and 250 μm i.d.). The smaller tube was inserted into the larger one through a T-type joint. The reaction of a protein with a fluorescence derivatizing reagent was adopted as a model. A water-acetonitrile mixture (3:1 volume ratio) including bovine serum albumin (hydrophilic) was delivered into the large tube from the inside through the small tube and an acetonitrile-Et acetate mixture (7:4 volume ratio) containing fluorescamine (hydrophobic) as a derivatizing reagent was delivered from the outside through the joint. Solutions were mixed through the double capillary tubes to promote ternary mixed carrier solvents (water-acetonitrile-Et acetate; 1:2:1 volume ratio). The liquid-liquid interface was created based on the tube radial distribution of ternary solvents in the larger tube. The derivatization reaction was performed in the larger,or reaction, tube in the micro-flow system. The. fluorescence intensity of the fluorescamine-derivatized bovine serum albumin obtained by the system, which specifically included the kinetic liquid-liquid interface in the tube, was greater than that obtained through a batch reaction using a homogeneous solution of water-acetonitrile (1:2 volume ratio). In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Product Details of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Product Details of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Hantzsch pre-column derivatization for simultaneous determination of alendronate sodium and its pharmacopoeial related impurity: Comparative study with synchronous fluorometry using fluorescamine was written by El-Yazbi, Amira F.;El-Kimary, Eman I.;Youssef, Rasha M.. And the article was included in Journal of Food and Drug Analysis in 2019.Computed Properties of C17H10O4 This article mentions the following:

High performance liquid chromatog. (HPLC) method with a pre-column derivatization based on Hantzsch condensation reaction was applied for simultaneous determination of alendronate sodium (ALN) and its main related impurity, 4-Aminobutanoic acid (ABA) at its pharmacopeial limit. The separation of colored condensation products of ALN and ABA were achieved on Agilent Zobrax Eclipse SB-C18 anal. column (250 × 4.6 mm, 5μm) using a mobile phase composed of acetonitrile-0.1 M acetate buffer, pH 5.0 (15:85, volume/volume). The flow rate was 1 mL min^-1. The detection was carried out at 340 nm using photo-diode array detector. Peak areas were used for the linear regression line in the range of 10-500 and 0.2-40μg mL^-1 for ALN and ABA, resp. Different conditions for the optimization of the derivatization reactions as well as for the HPLC measurement were studied. The proposed method was validated for linearity, precision, accuracy, specificity and robustness. This method was used to check the purity of ALN in the presence of ABA (related impurity) at the pharmacopeial limit (0.5%). For comparison purpose, another method was proposed which involves synchronous fluorescence measurement after ALN reaction with fluorescamine. In this method, the third derivative synchronous spectra were estimated as peak to peak measurement from 339 to 370 nm for ALN determination with LOD and LOQ of 24 and 73 ng mL^-1, resp., showing very high sensitivity. Both methods have been applied for determination of the alendronate sodium (ALN) in bulk and pharmaceutical preparations without interference of additives in tablets or oral solution In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Computed Properties of C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Computed Properties of C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Gold-seeded lithium niobate nanoparticles: influence of gold surface coverage on second harmonic properties was written by Taitt, Rachael;Urbain, Mathias;Behel, Zacharie;Pablo-sainz-ezquerra, Ana-Maria;Kandybka, Iryna;Millet, Eloise;Martinez-Rodriguez, Nicolas;Yeromonahos, Christelle;Beauquis, Sandrine;Le Dantec, Ronan;Mugnier, Yannick;Brevet, Pierre-Francois;Chevolot, Yann;Monnier, Virginie. And the article was included in Nanomaterials in 2021.Recommanded Product: 38183-12-9 This article mentions the following:

Hybrid nanoparticles composed of an efficient nonlinear optical core and a gold shell can enhance and tune the nonlinear optical emission thanks to the plasmonic effect. However the influence of an incomplete gold shell, i.e., isolated gold nano-islands, is still not well studied. Here LiNbO3 (LN) core nanoparticles of 45 nm were coated with various densities of gold nano-seeds (AuSeeds). As both LN and AuSeeds bear neg. surface charge, a pos.-charged polymer was first coated onto LN. The number of polymer chains per LN was evaluated at 1210 by XPS and confirmed by fluorescence titration Then, the surface coverage percentage of AuSeeds onto LN was estimated to a maximum of 30% using ICP-AES. The addition of AuSeeds was also accompanied with surface charge reversal, the neg. charge increasing with the higher amount of AuSeeds. Finally, the first hyperpolarizability decreased with the increase of AuSeeds d. while depolarization values for Au-seeded LN were close to the one of bare LN, showing a predominance of the second harmonic volumic contribution. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Recommanded Product: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Recommanded Product: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A glutathione-responsive sulfur dioxide polymer prodrug selectively induces ferroptosis in gastric cancer therapy was written by Xia, Mingjie;Guo, Zhihui;Liu, Xinming;Wang, Yang;Xiao, Chunsheng. And the article was included in Biomaterials Science in 2022.Electric Literature of C17H10O4 This article mentions the following:

Nanoparticle-induced ferroptosis has been proven to be an appealing strategy in cancer treatment. Previously, we reported the synthesis of an amphiphilic polymer prodrug of SO2, mPEG-PLG(DNs), which could self-assemble to formulate nanoparticles (NP-DNs) and trigger cancer cell death by GSH consumption and SO2 release. In the current study, the potential mechanism of NP-DNs-induced cell death was further investigated. We demonstrated that NP-DNs exhibited efficient antitumor activity against gastric cancer via ferroptosis. NP-DNs could selectively accelerate lipid peroxidation through GSH depletion and SO2 generation in gastric cancer cells. In addition, the NP-DNs-induced GPX4 reduction played a collaborative role in ferroptosis. Concurrently, in vivo evaluations revealed that NP-DNs not only exhibited excellent antitumor efficiency via ferroptosis but also caused little systemic toxicity in mice. All the results showed that NP-DNs would be a promising prodrug in precision-targeted ferroptosis therapy. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Electric Literature of C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Electric Literature of C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and stability of vinyl ketones in the 2-position of benzofuran was written by Faure, Robert;Mattioda, Georges. And the article was included in Bulletin de la Societe Chimique de France in 1973.Product Details of 38220-75-6 This article mentions the following:

2-Benzofuryl vinyl ketones I (R = H, Me, Et; R1 = Me; R2 = H, OMe, Cl) were prepared by Mannich reaction of 2-acylbenzofurans and hydrolysis of the Mannich bases. I (R1 = H) were too unstable to be isolated before they polymerized In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Product Details of 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Product Details of 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem