Tag: 200-300

Optical Properties of Poly(2-(5-bromo benzofuran-2-yl)-2-oxoethyl methacrylate)/Organoclay Nanocomposites was written by Kurt, Adnan;Koca, Murat. And the article was included in Arabian Journal for Science and Engineering in 2015.Related Products of 38220-75-6 This article mentions the following:

Novel nanocomposites of benzofuran-containing polymer poly(2-(5-bromo benzofuran-2-yl)-2-oxoethyl methacrylate) with different contents of organoclay were prepared and characterized with FTIR, XRD and SEM techniques. The thermal decomposition temperature of poly(BOEMA)/organoclay nanocomposites is higher than that of pure poly(BOEMA) about 5-14 °C at 10% weight loss. The optical characterization was tested with a UV-VIS spectrophotometer. Transmittances of nanocomposites decreased to lower values by organoclay loading. Dispersion parameters such as steepness parameter, single-oscillator parameter, average oscillator position and strength and moments of the imaginary part of the optical spectrum were changed as a function of organoclay nanofiller. As the organoclay content increased to 5% in the polymer matrix, the existence of wide-band tails increased to 1.30 eV, whereas the optical energy gap decreased to 2.92 eV. Anal. reveals that the type of transition is the indirectly allowed one. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Related Products of 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Related Products of 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Green and sensitive spectrofluorimetric method for the determination of two cephalosporins in dosage forms was written by Abdel-Aziz, Heba;Tolba, M. M.;El-Enany, N.;Aly, F. A.;Fathy, M. E.. And the article was included in Royal Society Open Science in 2021.Category: benzofurans This article mentions the following:

Using two green and sensitive spectrofluorimetric methods, we quantified two cephalosporins, cefepime (CFM) and cefazolin (CFZ), in raw and pharmaceutical formulations. The first method is based on the reaction between CFM and fluorescamine (borate buffer, pH 8), which yields a highly fluorescent product. After excitation at 384 nm, the fluorescent product emits light at 484 nm. At concentration ranges from 12.0 to 120.0 ng ml^-1, the relative fluorescence intensity/concentration curve was linear with a limit of quantification (LOQ) of 2.46 ng ml^-1. The second method relied on measuring the CFZ quenching action on acriflavine fluorescence through formation of an ion-associate complex using Britton-Robinson buffer at pH 8. We measured acriflavine fluorescence at 505 nm after excitation at 265 nm. The decrease in acriflavine fluorescence intensity was CFZ concentration-dependent. Using this method, we quantified CFZ in concentrations ranging from 1 to 10 μg ml^-1 with a LOQ of 0.48 μg ml^-1. We studied and optimized the factors influencing reaction product formation. Moreover, we adapted our methods to the investigation of the mentioned drugs in raw and pharmaceutical formulations with greatly satisfying results. We statistically validated our methods according to International Council on Harmonisation Guidelines. The obtained results were consistent with those obtained with the official high-performance liquid chromatog. methods. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Category: benzofurans).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Utility of experimental design in pre-column derivatization for the analysis of tobramycin by HPLC-fluorescence detection: application to ophthalmic solution and human plasma was written by El-Zaher, Asmaa A.;Mahrouse, Marianne A.. And the article was included in Analytical Chemistry Insights in 2013.Formula: C17H10O4 This article mentions the following:

A novel, selective, and sensitive reversed phase high-performance liquid chromatog. (HPLC) method coupled with fluorescence detection was developed for the determination of tobramycin (TOB) in pure form, in ophthalmic solution, and in spiked human blood plasma. Since TOB lacks UV absorbing chromophores and native fluorescence, pre-column derivatization of TOB was carried out using fluorescamine reagent (0.01%, 1.5 mL) and borate buffer (pH 8.5, 2 mL). Exptl. design was applied for optimization of the derivatization step. The resulting highly fluorescent stable derivative was chromatographed on C₁₈ column and eluted using MeOH:water (60:40, volume/volume) at a flow rate of 1 mL min^-1. A fluorescence detector (λ_ex 390, and λ_em 480 nm) was used. The method was linear over the concentration range 20-200 ng mL^-1. The structure of the fluorescent product was proposed, the method was then validated and applied for the determination of TOB in human plasma. The results were statistically compared with the reference method, revealing no significant difference. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Trace determination of lenalidomide in plasma by non-extractive HPLC procedures with fluorescence detection after pre-column derivatization with fluorescamine was written by Khalil, Nasr Y.;Darwish, Ibrahim A.;Wani, Tanveer A.;Al-Majed, Abdel-Rahman A.. And the article was included in Chemistry Central Journal in 2013.Reference of 38183-12-9 This article mentions the following:

Background: Lenalidomide (LND) is a new potent drug used for treatment of multiple myeloma. For its pharmacokinetic studies and therapeutic monitoring, a proper anal. method was required. Results: In this study, a non extractive and simple pre-column derivatization procedures have been proposed, for the for trace determination of lenalidomide (LND) in human plasma by HPLC with fluorescence detection. Plasma samples were treated with acetonitrile for protein precipitation then treated with copper acetate to form stable complexes with the biogenic amines and mask their interference with the derivatization reaction of LND. Treated plasma samples containing LND was derivatized with fluorescamine (FLC) in aqueous media at ambient temperature Separation of the derivatized LND was performed on Hypersil BDS C18 column (250 × 4.6 mm, 5 μm particle size) using a mobile phase consisting of phosphate buffer (pH 4):methanol:tetrahydrofuran (70:10:20, volume/volume) at a flow rate of 1.0 mL/min. The derivatized samples were monitored at an emission wavelength of 495 nm after excitation at a wavelength of 382 nm. Under the optimum chromatog. conditions, a linear relationship with good correlation coefficient (r = 0.9997, n = 9) was found between the peak area and LND concentrations in the range of 2-100 ng/mL. The limits of detection and quantitation were 0.8 and 2.30 ng/mL, resp. The intra- and inter-assay precisions were satisfactory and the accuracy of the method was proved. The recovery of LND from the spiked human plasma was 99.30 ± 2.88. Conclusions: The proposed method had high throughput as the anal. involved simple sample pre-treatment procedure and a relatively short run-time (<15 min). The results demonstrated that the method would have a great value when it is applied in the therapeutic monitoring and pharmacokinetic studies for LND. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Reference of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Reference of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers was written by Insua, Ignacio;Liamas, Evangelos;Zhang, Zhenyu;Peacock, Anna F. A.;Krachler, Anne Marie;Fernandez-Trillo, Francisco. And the article was included in Polymer Chemistry in 2016.Application of 38183-12-9 This article mentions the following:

Here we present new enzyme-responsive polyion complex (PIC) nanoparticles prepared from antimicrobial poly(ethylene imine) and an anionic enzyme-responsive peptide targeting Pseudomonas aeruginosa’s elastase. The synthetic conditions used to prepare these nanomaterials allowed us to optimize particle size and charge, and their stability under physiol. conditions. We demonstrate that these enzyme responsive PIC nanoparticles are selectively degraded in the presence of P. aeruginosa elastase without being affected by other endogenous elastases. This enzyme-responsive PIC particle can exert an elastase-specific antimicrobial effect against P. aeruginosa without affecting non-pathogenic strains of these bacteria. These targeted enzyme-responsive PIC nanoparticles constitute a novel platform for the delivery of antimicrobial peptides and polymers, and can be a powerful tool in the current race against antimicrobial resistance. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Application of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Application of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation was written by Abdelrahman, Mohamed A.;Eldehna, Wagdy M.;Nocentini, Alessio;Ibrahim, Hany S.;Almahli, Hadia;Abdel-Aziz, Hatem A.;Abou-Seri, Sahar M.;Supuran, Claudiu T.. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020.Category: benzofurans This article mentions the following:

Pursuing on our efforts toward searching for efficient hCA IX and hCA XII inhibitors, herein we report the design and synthesis of new sets of benzofuran-based sulfonamides, featuring the zinc anchoring benzenesulfonamide moiety linked to a benzofuran tail via a hydrazine or hydrazide linker. All the target benzofurans were examined for their inhibitory activities toward isoforms hCA I, II, IX, and XII. The target tumor-associated hCA IX and XII isoforms were efficiently inhibited with K_Is spanning in ranges 10.0-97.5 and 10.1-71.8 nM, resp. Interestingly, arylsulfonehydrazones displayed the best selectivity toward hCA IX and XII over hCA I (SIs: 39.4-250.3 and 26.0-149.9, resp.), and over hCA II (SIs: 19.6-57.1 and 13.0-34.2, resp.). Furthermore, the target benzofurans were assessed for their anti-proliferative activity, according to US-NCI protocol, toward a panel of sixty cancer cell lines. Only benzofurans and possessed selective and moderate growth inhibitory activity toward certain cancer cell lines. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Category: benzofurans).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Preparation and Properties of Cationic Gelatin Cross-Linked with Tannin was written by Yu, Ning;Li, Junying;Ma, Feng;Yang, Pengfei;Liu, Wenjie;Zhou, Mingyang;Zhu, Zhifei;Xing, Shu. And the article was included in Journal of Agricultural and Food Chemistry in 2020.Reference of 38183-12-9 This article mentions the following:

A kind of biomaterial with antibacterial and mech. properties was prepared using gelatin (GE) as a raw material. GE was modified by antibacterial epoxy quaternary ammonium salt (QAS) and then crosslinked with tannic acid (TA). Anal. of the Fourier transform IR spectroscopy (FTIR) results showed that the cationic group was grafted onto GE by reaction of the amino of GE with the epoxy of QAS, and the crosslinking occurred between the amino of GE and the active groups of TA under alk. conditions. The crosslinking degree was determined by the fluorescence method via a derivative reaction of fluorescamin. The influence of the crosslinking degree on the phys. and chem. properties of the GE film was studied by SEM, differential scanning calorimetry (DSC), thermogravimetric anal. (TGA), X-ray diffraction (XRD), and mech. testing. The results showed that the modified GE film formed a compact crosslinking structure, and its thermostability and mech. properties were improved with increasing crosslinking degree. The in vitro antibacterial rate of the crosslinked cationic GE film to Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) reached 95.83% and 100% resp., and the in vitro cell relative growth rate (RGR) of HeLa cells cultured in the extracted leachate of the crosslinked cationic GE film exceeded 85%, which illustrated that the modified GE film had excellent antibacterial activity and biocompatibility. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Reference of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Reference of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and antimicrobial activity of some imidazothiazole derivatives of benzofuran was written by Shankerrao, Sheelavanth;Bodke, Yadav D.;Santoshkumar, S.. And the article was included in Arabian Journal of Chemistry in 2017.Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

A series of 6-(5-substituted-benzofuran-2-yl)-3-phenylimidazo[2,1-b][1,3]thiazoles I (R¹ = H, Br; R² = H, CH₃, F) and 3,6-bis(5-substituted-benzofuran-2-yl)imidazo[2,1-b][1,3]thiazoles II (R³ = H, Br) was synthesized by the reaction of 1-(1-benzofuran-2-yl)-2-bromoethanones such as 1-(1-benzofuran-2-yl)-2-bromoethanone, 2-bromo-1-(5-bromo-1-benzofuran-2-yl)ethanone with 4-phenyl-1,3-thiazol-2-amines such as 4-phenyl-thiazol-2-ylamine, 4-p-tolyl-thiazol-2-ylamine, 4-(4-fluoro-phenyl)-thiazol-2-ylamine and 4-benzofurano-1,3-thiazol-2-amines such as 4-(1-benzofuran-2-yl)-1,3-thiazol-2-amine, 4-(5-bromo-1-benzofuran-2-yl)-1,3-thiazol-2-amine resp. The structures of newly synthesized compounds I and II were characterized by IR, ¹H NMR and mass spectroscopic studies and screened for their antimicrobial activities. The preliminary results revealed that some of the compounds exhibited promising antimicrobial activities. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Recommanded Product: 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A mix-and-click method to measure amyloid-β concentration with sub-micromolar sensitivity was written by Xue, Christine;Lee, Yoon Kyung;Tran, Joyce;Chang, Dennis;Guo, Zhefeng. And the article was included in Royal Society Open Science in 2017.Formula: C17H10O4 This article mentions the following:

Aggregation of amyloid-β (Aβ) protein plays a central role in Alzheimer’s disease. Because protein aggregation is a concentration-dependent process, rigorous investigations require accurate concentration measurements. Owing to the high aggregation propensity of Aβ protein, working solutions of Aβ are typically in the low micromolar range. Therefore, an ideal Aβ quantification method requires high sensitivity without sacrificing speed and accuracy. Absorbance at 280nm is frequently used to measure Aβ concentration, but the sensitivity is low with only one tyrosine and no tryptophan residues in the Aβ sequence. Here we present a fluorescence method for Aβ quantification using fluorescamine, which gives high fluorescence upon reaction with primary amines.We show that, using hen egg white lysozyme as a standard, fluorescence correlates linearly with primary amine concentration across a wide range of fluorescamine concentrations, from 62.5 to 1000μM. The maximal sensitivity of detection is achieved at a fluorescamine concentration of 250μM or higher. The fluorescamine method is compatible with the presence of DMSO, which is commonly used in the preparation of Aβ oligomers, and limits the use of absorbance at 280nm due to its high background reading. Using aggregation kinetics, we show that the fluorescaminemethod gives accurate concentration measurements at low micromolar range and leads to highly consistent aggregation data. We recommend the fluorescamine assay to be used for routine and on-thefly concentration determination in Aβ oligomerization and fibrillization experiments In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

One-pot synthesis of novel symmetric 1,5-di(benzofuran-2-yl)-3-(4-substituted-aryl)-pentane-1,5-dione derivatives was written by Aruna, Kumar D. B.;Desai, Nivedita R.;Krishnaswamy, G.;Sreenivasa, S.;Mahadevan, K. M.. And the article was included in Indian Journal of Chemistry in 2014.Product Details of 38220-75-6 This article mentions the following:

Cyclocondensation of 5-R-2-hydroxybenzaldehydes (R = H, Cl, Br, O₂N) with bromoacetone under basic conditions in ethanol afforded the corresponding 5-R-2-acetylbenzofurans. Subsequent cross-aldol reaction/Michael addition of the latter with various aromatic aldehydes 4-R¹C₆H₄CHO (R¹ = H, Cl, O₂N, MeO) by grinding in the presence of a base in min. amount of acetonitrile at room temperature afforded novel sym. 1,5-di(benzofuran-2-yl)-3-arylpentane-1,5-diones I. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Product Details of 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Product Details of 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem