Some tips on 13391-28-1

The synthetic route of 13391-28-1 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13391-28-1,5-Methoxybenzofuran,as a common compound, the synthetic route is as follows.

To a stirred solution of 5-methoxybenzofuran (1) (0.50 g, 3.38 mmol) in dichloromethane (15 mL), boron tribromide (16.87 mL, 16.87 mmol, IM solution in dichloromethane) was added slowly at O0C. The reaction mixture was warmed to room temperature and stirred for 4 hours. The reaction mixture was then cooled to O0C, quenched with aqueous saturated NaHCO3 solution and extracted with dichloromethane (3 x 50 mL). The combined organic extracts were washed with brine (25 mL), dried over Na2SO4, and concentrated under reduced pressure to give compound (2) as an off white solid (300 mg) which was used in the next step without further purification. 1H NMR (400 MHz, CHLOROFORM-J) delta: 7.59 (d, J=I.95 Hz, 1 H), 7.35 (d, J=8.59 Hz, IH), 7.00 (d, J=2.73 Hz, IH), 6.80 (dd, 8.59, 2.74 Hz, IH), 6.67 (m, IH), 4.66 (s, IH)

The synthetic route of 13391-28-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; BJOeRK, Seth; DELISSER, Vern; JOHNSTROeM, Peter; NILSSON, Nils Anders; RUDA, Katinka; SCHOU, Per Magnus; SWAHN, Britt-Marie; WO2010/24769; (2010); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem