In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Scalable biocatalytic synthesis of optically pure ethyl (R)-2-hydroxy-4-phenylbutyrate using a recombinant E. coli with high catalyst yield, published in 2013-12-31, which mentions a compound: 90866-33-4, mainly applied to Escherichia whole cell carbonyl reductase glucose dehydrogenase asym reduction; (R)-2-hydroxy-4-phenylbutanoate; Asymmetric reduction; Biocatalysis; Carbonyl reductase; Coexpression, Application of 90866-33-4.
Et (R)-2-hydroxy-4-phenylbutanoate [(R)-HPBE] is a versatile and important chiral intermediate for the synthesis of angiotensin-converting enzyme (ACE) inhibitors. Recombinant E. coli strain coexpressing a novel NADPH-dependent carbonyl reductase gene iolS and glucose dehydrogenase gene gdh from Bacillus subtilis showed excellent catalytic activity in (R)-HPBE production by asym. reduction IolS exhibited high stereoselectivity (>98.5% ee) toward α-ketoesters substrates, whereas fluctuant ee values (53.2-99.5%) for β-ketoesters with different halogen substitution groups. Strategies including aqueous/organic biphasic system and substrate fed-batch were adopted to improve the biocatalytic process. In a 1-L aqueous/octanol biphasic reaction system, (R)-HPBE was produced in 99.5% ee with an exceptional catalyst yield (gproduct/gcatalyst) of 31.7 via bioreduction of Et 2-oxo-4-phenylbutyrate (OPBE) at 330 g/L.
When you point to this article, it is believed that you are also very interested in this compound(90866-33-4)Application of 90866-33-4 and due to space limitations, I can only present the most important information.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem