4265-16-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4265-16-1,Benzo[b]furan-2-carboxaldehyde,as a common compound, the synthetic route is as follows.
In a 25 mL two-necked round bottom flask equipped with a thermometer and a magnetic stirrer4 mmolofBenzofuran-2-carbaldehyde (1-19), 6 mmol of NH4OAc, 4 mmol of Na2CO3, 4.4 mmol of TBHP, 0.1 mmol of I2, 5 mL of absolute ethanol Solvent, followed by placing the reaction flask in an oil bath preheated to 50 C and opening the magnetic stirrer for 5 h. The reaction solution By adding sodium thiosulfate solution, stirring, and then extracting with ether, separating the organic layer, and removing the solvent under reduced pressure, The eluate was collected with the mixture of ethyl acetate / petroleum ether in a volume ratio of 1: 100 as the eluent, and the eluate containing the target compound was collected. The solvent was distilled off to give benzofuran-2-carbonitrile with an isolated yield of 72%.
The synthetic route of 4265-16-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Zhejiang University of Technology; Shen Zhenlu; Li Meichao; Fang Chaojie; Mo Weimin; (12 pag.)CN106748881; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem