Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 4412-91-3, Name is 3-Furanmethanol, molecular formula is C5H6O2, belongs to benzofurans compound. In a document, author is Ghosh, Debasis, introduce the new discover, Recommanded Product: 3-Furanmethanol.
Dihydrophthalazinediones accelerate amyloid beta peptide aggregation to nontoxic species
The production and accumulation of toxic amyloid plaques is one of the hallmarks of Alzheimer’s disease (AD). Amyloid beta (A beta) peptides undergo self-aggregation to form soluble oligomers, protofibrils and insoluble fibrils. This process is termed as amyloidogenesis and is a major contributor to the observed neuronal damage and memory impairment in the AD brain. Therefore, modulation of A beta aggregation process is considered to be an effective target to prevent neuronal damage under AD conditions. Modulation of amyloidogenesis involves inhibition of aggregation to form a toxic species or acceleration to drive the aggregation process to form species that are nontoxic by employing well-designed external ligands. In this context, we report a set of 2,3-dihydrophthalazine-1,4-dione (dihydrophthalazinedione, Phz) based small molecules (Phz 1-4) to modulate the A beta 42 aggregation and in cellular toxicity. Our detailed study (thioflavin T fluorescence assay, dot blot and transmission electron microscopy analysis) revealed fluorine containing Phz 4 as the potent modulator of A beta 42 aggregation by accelerating the process to form nontoxic aggregated species through hydrophobic and halogen interactions. A beta 42 aggregates formed in the presence of Phz 4 are mostly nontoxic when compared to the normal amyloid aggregates in the cellular milieu (PC12 cells). This study established that the hydrophobic and halogen interactions can be employed to develop anti-AD drug candidates. The excellent cell viability, effective modulation of A beta 42 aggregation to form nontoxic species and cellular (neuronal) rescue by Phz 4 offer a novel platform to develop therapeutic strategies for AD.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 4412-91-3. Recommanded Product: 3-Furanmethanol.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem