Application of 14400-67-0, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, SMILES is O=C1C(C)OC(C)=C1, belongs to benzofurans compound. In a article, author is Wang, Feng, introduce new discover of the category.
Identification of novel STAT3 inhibitors bearing 2-acetyl-7-phenylamino benzofuran scaffold for antitumour study
Signal transducer and activator of transcription 3 (STAT3) is identified as a promising target for multiple cancer therapy and attracts widespread concern. Herein, we reported the discovery of a series of 2-acetyl-7-phenylamino benzofuran derivatives as STAT3 inhibitors using scaffold fusion strategy. Further structure activity relationship study led to the discovery of compound C6, which displayed the most potent anti-proliferation activities against MDA-MB-468 cells (IC50 = 0.16 mu M). Western blot assay demonstrated that C6 inhibited the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701). Further mechanistic studies indicated that C6 caused a notable G2/M cycle-arresting and early apoptosis in a concentration-dependent manner in MDA-MB468 cells. Finally, molecular modelling study elucidated the binding mode of C6 in STAT3 SH2 domain.
Application of 14400-67-0, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 14400-67-0.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem