Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Baker’s yeast: production of D- and L-3-hydroxy esters.Category: benzofurans.
Baker’s yeast grown under oxygen limited conditions and used in the reduction of 3-oxo esters results in a shift of the stereoselectivity of the yeast towards D-hydroxy esters as compared with ordinary baker’s yeast. The highest degree of stereoselectivity was obtained with growing yeast or yeast harvested while growing. In contrast, the stereoselectivity was shifted towards L-hydroxy esters when the oxo esters were added slowly to ordinary baker’s yeast supplied with gluconolactone as co-substrate. The reduction rate with gluconolactone was increased by active aeration. Et L-(S)-3-hydroxybutanoate was afforded in >99% ee. Both enantiomers of Et 3-hydroxypentanoate, D-(R) in 96% ee and L-(S) in 93% ee, and of Et 4-chloro-3-hydroxybutanoate, D-(S) in 98% ee and L-(R) in 94% ee, were obtained. The results demonstrate that the stereoselectivity of baker’s yeast can be controlled to a large extent without the use of inhibitors, heat treatment, etc.
In some applications, this compound(90866-33-4)Category: benzofurans is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem