One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Safety of Benzofuran-2-carboxylic acid, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 496-41-3, Name is Benzofuran-2-carboxylic acid, molecular formula is C9H6O3
On the basis of our recently resolved first cocrystal structure of Mdm4 in complex with a small molecule inhibitor (PDB ID 3LBJ), we devised an approach for the generation of potential Mdm4 selective ligands. We performed the Ugi four-component reaction (Ugi-4CR) in 96-well plates with an indole fragment, which is specially designed to mimic Trp23, a key amino acid for the interaction between p53 and Mdm4. Generally the reaction yielded mostly precipitates collected by 96-well filter plates. The best hit compound was found to be active and selective for Mdm4 (Ki = 5 muM, 10-fold stronger than Mdm2). This initial hit may serve as the starting point for designing selective p53-Mdm4 inhibitor with higher affinity.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Safety of Benzofuran-2-carboxylic acid, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 496-41-3, in my other articles.
Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1744O – PubChem