Electric Literature of 174775-48-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 174775-48-5, Name is Ethyl 5-aminobenzofuran-2-carboxylate, SMILES is O=C(C1=CC2=CC(N)=CC=C2O1)OCC, belongs to benzofurans compound. In a article, author is He, Xinwei, introduce new discover of the category.
A ZnI2-catalyzed regioselective cascade 1,4-conjugate addition/5-exo-dig annulation pathway for one-pot access to heterobiaryl frameworks
Facile access to pi-extended heterobiaryl compounds via a non-cross-coupling strategy has been achieved. In the presence of an inexpensive ZnI2 catalyst and versatile propargylamine and beta-naphthol (or beta-naphthylamine and beta-naphthyl mercaptan) starting materials, a variety of sterically hindered heterobiaryl frameworks can be easily obtained. The present catalytic system offers excellent selectivity, good-to-excellent product yields, and good functional group tolerance including, for instance, -CN, -COOH, -C(O)R, -Br and -Cl groups. This cyclization process is proposed to proceed via in situ generated alkynyl o-quinone methides (o-AQMs), following a cascade intermolecular 1,4-conjugate addition/5-exo-dig annulation/1,3-H shift pathway.
Electric Literature of 174775-48-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 174775-48-5.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem