Domino [Pd]-Catalysis: One-Pot Synthesis of Isobenzofuran-1(3H)-ones was written by Mahendar, Lodi;Satyanarayana, Gedu. And the article was included in Journal of Organic Chemistry in 2016.Formula: C9H8O3 This article mentions the following:
An efficient domino [Pd]-catalysis for the synthesis of isobenzofuran-1(3H)-ones is presented. The strategy shows broad substrate scope and is amenable to o-bromobenzyl tertiary/secondary/primary alcs. Significantly, the method was applied to the synthesis of antiplatelet drug Bu phthalide and cytotoxic agonist 3a-[4′-methoxylbenzyl]-5,7-dimethoxyphthalide. In the experiment, the researchers used many compounds, for example, 5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2Formula: C9H8O3).
5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Formula: C9H8O3
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem