Application In Synthesis of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Study of two new non-steroid antiinflammatory drugs having a pyrazole structure (LM 22070 and LM 22102). Author is Mizoule, J.; Le Fur, G.; Uzan, A..
Two derivatives from a new heteroarylacetic series, LM 22102 (I) [50270-32-1] and LM 22070 (II) [50270-33-2], were selected on the basis of their antiinflammatory, analgesic, and antipyretic properties. In the mouse, I and II, resp., were 15 and 30 times less active than indomethacin ethanolamine salt [71227-27-5] in Koster’s test, but they were 9 and 13 times less toxic than the reference drugs. In contrast, they were very active in the rat and the guinea pig. I was as active as indomethacin in the various tests . In vitro, its inhibition of prostaglandin synthetase [9055-65-6] in guinea pig lung was more powerful than that of indomethacin. Like all potent nonsteroid antiinflammatory drugs I had ulcerogenic activity, similar to that of indomethacin, which accounted for its acute oral toxicity in the rat. The activities of II were either the same as (antipyretic action) or inferior to (analgesic and antiinflammatory activity and inhibition of prostaglandin synthetase) that of indomethacin, but were always superior to those of phenylbutazone sodium salt [129-18-0]. Its ulcerogenic activity and oral acute toxicity in the rat are 2.5- and 3-fold weaker than those of indomethacin, resp.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem