Houbion, J. A. published the artcileThe synthesis of unambiguously substituted 3-hydroxyphthalides, Quality Control of 52010-22-7, the main research area is phthalide hydroxy; hydroxyphthalide; toluate bromination cyclization; formylphenyloxazoline hydrolysis cyclization; oxazolinylbenzaldehyde hydrolysis cyclization.
Hydroxyphthalides I (R = 4-, 6-, 7-Cl; 4-, 6-MeO) were obtained in 61-98% yield by photochem. bromination of II followed by hydrolysis. II (R = 4-MeO, 6-NO2) were obtained from R-2-MeC6H3CO2H by successive bromination and cyclization. I (R = 5-Cl, 5-MeO) were obtained in 63-71% yield by hydrolysis of III. III were obtained by ortho metalation-formylation of para substituted 2-aryloxazolines.
Organic Preparations and Procedures International published new progress about phthalide hydroxy; hydroxyphthalide; toluate bromination cyclization; formylphenyloxazoline hydrolysis cyclization; oxazolinylbenzaldehyde hydrolysis cyclization. 52010-22-7 belongs to class benzofurans, name is 4-Chlorophthalide, and the molecular formula is C8H5ClO2, Quality Control of 52010-22-7.
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem