A novel synthesis of benzofuran and related compounds. I. The Vilsmeier reaction of phenoxyacetonitriles was written by Hirota, Takashi;Fujita, Hiroko;Sasaki, Kenji;Namba, Tetsuto;Hayakawa, Shohei. And the article was included in Journal of Heterocyclic Chemistry in 1986.Synthetic Route of C10H8O4 This article mentions the following:
Vilsmeier reaction of phenoxyacetonitriles I (R, R1 = H, MeO; MeO, MeO; H, EtO; H, NEt2) was described. E.g., reaction of I (R, R1 = MeO, MeO), DMF, and POCl3 at molar ratio of 1:1.2:3.6 at 70° for 3 h gave 61% benzofuran II and 8.5% 4-formyl-3,5-dimethoxyphenoxyacetonitrile. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzofuran-2-carboxylic acid (cas: 50551-61-6Synthetic Route of C10H8O4).
6-Methoxybenzofuran-2-carboxylic acid (cas: 50551-61-6) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Synthetic Route of C10H8O4
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem