Highly Enantioselective Synthesis of 2,3-Dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-ones via Catalytic Asymmetric Intramolecular Cascade Imidization-Nucleophilic Addition-Lactamization was written by He, Yuwei;Cheng, Chuyu;Chen, Bin;Duan, Kun;Zhuang, Yue;Yuan, Bo;Zhang, Meisan;Zhou, Yougui;Zhou, Zihong;Su, Yu-Jun;Cao, Rihui;Qiu, Liqin. And the article was included in Organic Letters in 2014.Quality Control of 5-Methylisobenzofuran-1(3H)-one This article mentions the following:
Highly enantioselective catalytic asym. intramol. cascade imidization-nucleophilic addition-lactamization of N1-alkylethane-1,2-diamine with Me 2-formylbenzoate catalyzed by a chiral phosphoric acid represents the first efficient method for the preparation of medicinally interesting chiral 2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-ones, e.g., I, with high yields and excellent enantioselectivities. This strategy has been shown to be quite general toward various Me 2-formylbenzoates. In the experiment, the researchers used many compounds, for example, 5-Methylisobenzofuran-1(3H)-one (cas: 54120-64-8Quality Control of 5-Methylisobenzofuran-1(3H)-one).
5-Methylisobenzofuran-1(3H)-one (cas: 54120-64-8) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Quality Control of 5-Methylisobenzofuran-1(3H)-one
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem