496-41-3, Name is Benzofuran-2-carboxylic acid, belongs to benzofuran compound, is a common compound. Product Details of 496-41-3In an article, once mentioned the new application about 496-41-3.
Structure based design and syntheses of amino-1H-pyrazole amide derivatives as selective Raf kinase inhibitors in melanoma cells
The synthesis of a novel series of N-(5-amino-1-(4-methoxybenzyl)-1H- pyrazol-4-yl amide derivatives 6a-o, 7a-s and their antiproliferative activities against A375P melanoma cell line were described. Most compounds showed competitive antiproliferative activities to sorafenib, the reference standard. Among them, N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-(3-(4-chloro-3- (trifluoromethyl)phenyl) ureido)-2-methylbenzamide 7c exhibited potent activities (GI50 = 0.27 muM). Especially, 7c was found to be a potent and selective B-Raf V600E and C-Raf inhibitor (IC50 = 0.26 muM, IC50 = 0.11 muM, respectively), showing a possibility as melanoma therapeutics.
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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H1848O – PubChem