Final Thoughts on Chemistry for 10242-10-1

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, name: 5-Chlorobenzofuran-2-carboxylic acid, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 10242-10-1

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: 5-Chlorobenzofuran-2-carboxylic acid, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 10242-10-1, Name is 5-Chlorobenzofuran-2-carboxylic acid, molecular formula is C9H5ClO3

A disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4) and ADAMTS-5 are zinc metalloproteases commonly referred to as aggrecanase-1 and aggrecanase-2, respectively. These enzymes are involved in the degradation of aggrecan, a key component of cartilage. Inhibitors of these enzymes could be potential osteoarthritis (OA) therapies. A series of hydantoin inhibitors of ADAMTS-4 and ADAMTS-5 were identified from a screening campaign and optimized through structure-based drug design to give hydantoin 13. Hydantoin 13 had excellent selectivity over other zinc metalloproteases such as TACE, MMP2, MMP3, MMP13, and MMP14. The compound also produced efficacy in both a chemically induced and surgical model of OA in rats.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, name: 5-Chlorobenzofuran-2-carboxylic acid, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 10242-10-1

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3185O – PubChem