Fluorescent Nanoclays: Covalent Functionalization with Amine Reactive Dyes from Different Fluorophore Classes and Surface Group Quantification was written by Felbeck, Tom;Hoffmann, Katrin;Lezhnina, Marina M.;Kynast, Ulrich H.;Resch-Genger, Ute. And the article was included in Journal of Physical Chemistry C in 2015.Formula: C17H10O4 This article mentions the following:
The ever increasing applications of fluorescence techniques in conjunction with the interest in enhanced detection sensitivities in bioanal., biosensing, and bioimaging are closely linked to the rational design of novel nontoxic fluorescent nanomaterials with improved brightness and stability that can be reproducibly synthesized from inexpensive starting materials in simple one-pot reactions and easily surface functionalized. This encouraged the authors to study the potential of the com. available water-dispersible nanoclay Laponite RD with the empirical formula Na0.7(H2O)n{(Li0.3Mg5.5)[Si8O20(OH)4]}, forming 25 nm sized disk-shaped particles, as nanocarriers for different fluorophores. The Si-OH functions at the rims of these disks can be selectively grafted with 3-aminopropyldimethylethoxysilane (APES), thereby enabling subsequent coupling to amine-reactive mols. ranging from target-specific organic ligands and biomols. to amine-reactive fluorescent labels. Here, the authors present different strategies for the surface functionalization of nanoclays and the subsequent quantification of the d. of synthetically introduced surface amino groups exploiting anal. methods which rely on different detection schemes including elemental anal., colorimetric assays, and fluorophore labeling strategies. In this respect, the authors systematically assess the potential of neg. and pos. charged, neutral, and zwitterionic dyes to act as fluorescent labels for amino functionalities at the surface of neg. charged nanoclays. The authors’ studies underline the strong influence of dye charge and aggregation tendency on the brightness of the bound dyes and on surface group quantification. Best results regarding surface group anal. and coupling yield were obtained for a neutral dansyl derivative and fluorescamine. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Formula: C17H10O4).
4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Formula: C17H10O4
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem