Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Quality Control of 2,3-Dihydrobenzofuran-7-carboxylic acid. Introducing a new discovery about 35700-40-4, Name is 2,3-Dihydrobenzofuran-7-carboxylic acid
As a continuation of our studies of apoptosis inducing 9-oxo-9H-fluorene-1-carboxamides as potential anticancer agents, we explored modification of the 9-oxo-9H-fluorene ring. SAR studies showed that most changes to the 9-oxo-9H-fluorene ring were not well tolerated, except the 9H-fluorene (2b) and dibenzothiophene (2d) analogs, which were about twofold less active than the 9-oxo-9H-fluorene analog 2a. Significantly, introduction of substitutions at the 7-position of the 9-oxo-9H-fluorene ring led to compounds 5a-5c with improved activity. Compound 5a was found to have EC50 values of 0.15-0.29 muM against T47D, HCT116, and SNU398 cells, about fivefold more potent than the original lead 2a. As opposed to the original lead compound 2a, compounds 5a-5b were active in a tubulin inhibition assay, indicating a change of mechanism of action. The potent azido analog 5c could be utilized for target identification.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Quality Control of 2,3-Dihydrobenzofuran-7-carboxylic acid, you can also check out more blogs about35700-40-4
Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2202O – PubChem