27550-59-0, Name is 5-Hydroxyisobenzofuran-1,3-dione, belongs to benzofurans compound, is a common compound. category: benzofuranIn an article, once mentioned the new application about 27550-59-0.
Paecilocin A, a phthalide derivative isolated from the jellyfish-derived fungus Paecilomyces variotii, activates PPAR-gamma (Peroxisome proliferator-activated receptor gamma) in rat liver Ac2F cells. Based on a SAR (Structure-activity relationships) study and in silico analysis of paecilocin A-mimetic derivatives, additional N-substituted phthalimide derivatives were synthesized and evaluated for PPAR-gammaagonistic activity in both murine liver Ac2F cells and in human liver HepG2 cells by luciferase assay, and for adipogenic activity in 3T3-L1 cells. Docking simulation indicated PD6 was likely to bind most strongly to the ligand binding domain of PPAR-gamma by establishing crucial H-bonds with key amino acid residues. However, in in vitro assays, PD1 and PD2 consistently displayed significant PPAR-activation in Ac2F and HepG2 cells, and adipogenic activity in 3T3-L1 preadipocytes.
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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2146O – PubChem