The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Acute renal insufficiency following the therapeutic application of phenylbutazone》. Authors are Streicher, E..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Electric Literature of C19H19N2NaO2. Through the article, more information about this compound (cas:129-18-0) is conveyed.
Normal renal function was restored by means of extracorporeal dialysis in 4 cases of acute renal insufficiency apparently resulting from the administration of the phenylbutazone-containing drugs, Butazolidine, Delta-butazolidin, Irgapyrine, and Tomanol. A review was given of this and other side-reactions resulting from the administration of this class of drug. 71 references.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem