Development and validation of an ultra-performance liquid chromatography method for the determination of wedelolactone in rat plasma and its application in a pharmacokinetic study was written by Chen, Qing;Wu, Xiaoxue;Gao, Xuemin;Song, Hua;Zhu, Xuan. And the article was included in Molecules in 2019.Related Products of 524-12-9 The following contents are mentioned in the article:
Wedelolactone is a coumarin ether with significant hepatoprotective effects. However, there are few pharmacokinetic studies of wedelolactone, which will affect the studies of its efficacy and potential toxicity. In this study, a selective ultra-performance liquid chromatog. (UPLC) method was developed to confirm the pharmacokinetic parameters of wedelolactone in rat plasma. The chromatog. separation was carried out on a Kromasil C18 UPLC column (250 × 4.6 mm; 5.0 mum) by gradient mobile phase of methanol-water containing 0.5% acetic acid (volume/volume). Perfect linearity was obtained and the samples were stable under different conditions. The intra-day and inter-day precisions (relative standard deviation, %) were within 3.81% and accuracies (relative error, %) ranged from -4.01% to 7.12%. The extraction recoveries in rat plasma ranged from 95.98% to 108.93%. This rapid method was successfully applied in the pharmacokinetic study of wedelolactone in rat plasma. Following the oral administration of 5.00 mg/kg wedelolactone, the wedelolactone was rapidly absorbed. Pharmacokinetic parameters were used to quant. describe the dynamic changes of wedelolactone in vivo, providing a theor. basis for pharmacol. research on drugs and preclin. medication. The study of wedelolactone can provide a theor. basis and quick anal. for the study of other traditional Chinese medicine. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Related Products of 524-12-9).
1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Related Products of 524-12-9