Category: benzofurans

Application of 591-11-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 591-11-7, Name is 5-Methylfuran-2(5H)-one, SMILES is O=C1OC(C)C=C1, belongs to benzofurans compound. In a article, author is Li, Yang, introduce new discover of the category.

A FACILE SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL QUINOXALINE-BENZOFURAN HYBRIDS

In the present work, a simple and facile synthesis of a series of new type of quinoxaline-benzofuran hybrids, i.e., 3-(benzofuran-2-yl)quinoxaline-2-carboxylic acids has been achieved using the newly-synthesized ethyl 3-bromomethylquinoxaline-2-carboxylate as substrate through ultrasound-assisted one-pot sequential Rap-Stoermer type reaction with various salicylaldehydes followed by ester hydrolysis. A preliminary screening for their antibacterial activities against five bacterial strains revealed that compounds with tert-butyl and halo (Cl and Br) substituents exhibited promising inhibitory activity against B. subtilis with the MIC values of 15.625 and 7.8125 mu g/mL, respectively, being equipotent or even better than the reference Ciprofoxacin.

Application of 591-11-7, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 591-11-7 is helpful to your research.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Related Products of 497-23-4, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, belongs to benzofurans compound. In a article, author is Shi, Hongjin, introduce new discover of the category.

Divergent syntheses of spirooxindoles from oxindole-embedded four-membered synthon via cycloaddition reactions

The highly efficient construction of five and six membered heterocycle fused spirooxindoles was achieved via the [4 + 1] and formal [4 + 2] cycloaddition reactions between our rationally designed four-membered synthons and pyridinium methylides and alpha-bromoacetophenones, respectively. A wide range of richly decorated oxindole-containing chroman, chromen, and 2H-benzofuran derivatives were synthesized in moderate to high yields and diastereoselectivities.

Related Products of 497-23-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 497-23-4.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Li Jian, once mentioned the application of 87-41-2, Name is Isobenzofuran-1(3H)-one, molecular formula is C8H6O2, molecular weight is 134.13, MDL number is MFCD00005906, category is benzofurans. Now introduce a scientific discovery about this category, Formula: C8H6O2.

5,6-Difluoro-benzofuran: A new core structure for the design of liquid crystal compound

At present, liquid crystal with fused heterocyclic ring is an important direction of molecular structure design and development. In this paper, a new liquid crystal compound with 5, 6-difluorobenzofuran ring structure was synthesized via palladium catalyzed coupling reaction and ring closing reaction of cyclohexyl substituted acetylene and o-iodophenol derivative. The total yield was 54%. Its structure was characterized by H-1 NMR and MS, and its phase transition temperatures were tested by DSC and POM. It is found that the melting point and the clear point of the compound is 118 degrees C and 202 degrees C respectively, and the nematic temperature range is 84 degrees C. The physical properties test shows that the birefringence is about 0.13, the dielectric anisotropy is 12.6 and the rotational viscosity is 420 mPa . s. Compared with the similar 3 , 4-difluorobenzene liquid crystal compound, the birefringence of the compound containing 5 , 6-difluorobenzofuran ring increases by 65% , the dielectric constant increases by 97%, and the clear point increases by 66%. As a new kind of fluorine-containing building block, 5 , 6-difluorobenzofuran has outstanding comprehensive performance and good application prospect in the field of liquid crystal display.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 87-41-2, Name is Isobenzofuran-1(3H)-one, molecular formula is , belongs to benzofurans compound. In a document, author is Matiichuk, Yuliia, Safety of Isobenzofuran-1(3H)-one.

Synthesis and Anticancer Activity of Novel Benzofurancarboxamides

In our present work, presented an efficient synthesis and anticancer activity evaluation of some novel benzofurancarboxamides. Our proposed approaches provide the possibility to design benzofurans diversity with a considerable chemical novelty. The synthesized substances were selected by the National Cancer Institute (NCI) Developmental Therapeutics Program for the in vitro cell line screening to investigate their anticancer activity. The compounds with significant levels of anticancer activities have been found that can be used for further optimization.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 87-41-2, in my other articles. Safety of Isobenzofuran-1(3H)-one.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Application of 66357-35-5, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 66357-35-5, Name is Ranitidine, SMILES is O=[N+]([O-])/C=C(NCCSCC1=CC=C(O1)CN(C)C)NC, belongs to benzofurans compound. In a article, author is Abdelrahman, Mohamed A., introduce new discover of the category.

Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation

Pursuing on our efforts toward searching for efficient hCA IX and hCA XII inhibitors, herein we report the design and synthesis of new sets of benzofuran-based sulphonamides (4a,b, 5a,b, 9a-c, and 10a-d), featuring the zinc anchoring benzenesulfonamide moiety linked to a benzofuran tail via a hydrazine or hydrazide linker. All the target benzofurans were examined for their inhibitory activities toward isoforms hCA I, II, IX, and XII. The target tumour-associated hCA IX and XII isoforms were efficiently inhibited with K (I)s spanning in ranges 10.0-97.5 and 10.1-71.8 nM, respectively. Interestingly, arylsulfonehydrazones 9 displayed the best selectivity toward hCA IX and XII over hCA I (SIs: 39.4-250.3 and 26.0-149.9, respectively), and over hCA II (SIs: 19.6-57.1 and 13.0-34.2, respectively). Furthermore, the target benzofurans were assessed for their anti-proliferative activity, according to US-NCI protocol, toward a panel of sixty cancer cell lines. Only benzofurans 5b and 10b possessed selective and moderate growth inhibitory activity toward certain cancer cell lines.

Application of 66357-35-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 66357-35-5 is helpful to your research.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is He, Xingrui, once mentioned the application of 14400-67-0, Computed Properties of C6H8O2, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, molecular weight is 112.13, MDL number is MFCD00052571, category is benzofurans. Now introduce a scientific discovery about this category.

4-Hydroxy-3-methylbenzofuran-2-carbohydrazones as novel LSD1 inhibitors

Histone lysine specific demethylase 1 (LSD1 or KDM1A) is a potential therapeutic target in oncology due to its overexpression in various human tumors. We report herein a new class of benzofuran acylhydrazones as potent LSD1 inhibitors. Among the 31 compounds prepared, 14 compounds exhibited excellent LSD1 inhibitory activity with IC50 values ranging from 7.2 to 68.8 nM. In cellular assays, several compounds inhibited the proliferations of various cancer cell lines, including PC-3, MCG-803, U87 MG, PANG-1, HT-29 and MCF-7. This opens up the opportunity for further optimization and investigation of this class compounds for potential cancer treatment.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, COA of Formula: C5H6O24412-91-3, Name is 3-Furanmethanol, SMILES is OCC1=COC=C1, belongs to benzofurans compound. In a article, author is Fu, Zewu, introduce new discover of the category.

Catalytic Pyrolysis of Guaiacol over Ni/La-Modified Hierarchical HZSM-5

Catalytic pyrolysis of guaiacol as a model compound of lignin was conducted to explore the lignin pyrolysis mechanism in this study. The effects of catalyst and temperature on product distribution were studied. Five catalysts were tested including HZSM-5, hierarchical HZSM-5, metal-modified hierarchical HZSM-5 catalysts. And the Ni/La bimetallic hierarchical HZSM-5 (NiLa/HZ-SH) contributes to the achievement of high conversion and selectivity in catalytic pyrolysis of guaiacol. we obtained the yields of monocyclic aromatic hydrocarbons over NiLa/HZ-SH (550 degrees C): Phenol (23.01%), Benzofuran (6.68%), Salicylaldehyde (1.54%), 2-Methylphenol (31.48%), 4-Methylphenol (6.54%), 2-Ethylphenol (14.89%), 4-Vinylphenol (1.45%) and Catechol (8.67%), and the maximal yields of these monocyclic aromatic hydrocarbons is 94.26%. Moreover, the yield of polycyclic aromatic hydrocarbons (PAH) as the non-target product reached a minimum of 1.46% over NiLa/HZ-SH, while it was 16.88% without catalyst. In addition, catalyst stability was investigated, the reason that led to the decrease of target products could be the acidity and surface area of catalysts decreased as the coke blocked the pore channels, spent catalyst can be successfully regenerated through calcination treatment. Finally, based on the experiment results in this work and other published studies, a guaiacol pyrolysis mechanism was summarized and proposed aiming to understand the lignin pyrolysis process.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 4412-91-3. COA of Formula: C5H6O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.87-41-2, Name is Isobenzofuran-1(3H)-one, SMILES is O=C1OCC2=C1C=CC=C2, belongs to benzofurans compound. In a document, author is Fang, Zhuangjie, introduce the new discover, Category: benzofurans.

S-Bridged Thioether and Structure-Diversified Angucyclinone Derivatives from the South China Sea-Derived Micromonospora echinospora SCSIO 04089

Angucyclinces belong to the class of aromatic polyketides and display a wide variety of structure diversity and pharmaceutical significance. Herein we report the isolation, structure elucidation, and bioactivity evaluation of structure-diversified angucyclinone derivatives and anthracene from the South China Sea-derived Micromonospora echinospora SCSIO 04089, including a thioether, gephysulfuromycin (1), two new benzo[b]phenanthridines, homophenanthroviridone (2) and homophenanthridonamide (3), a new benzo[b]fluorene, homostealthin D (4), a new naphtho[2,3-b]benzofuran, nenesfuran (5), a new naphthoquinone, WS-5995 D (6) and a new anthracene, nenesophanol (7), together with three known compounds (8-10). Their structures were elucidated by extensive spectroscopic analyses. The structures of 1-3 and 5-8 were confirmed by X-ray crystallographic analyses. Gephysulfuromycin (1) featured a rare single S-bridged 3,12a-epithiotetraphene skeleton. Homophenanthroviridone (2) was found to be cytotoxic to SF-268, MCF-7, and HepG2 cell lines with IC50 values of 5.4 +/- 0.4, 6.8 +/- 0.3, and 1.4 +/- 0.1 mu M, respectively. Compound 2 was also active against Gram-positive bacteria with MIC (minimal inhibition concentration) values ranging 2-4 mu g mL(-1).

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 87-41-2. Category: benzofurans.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Product Details of 6296-53-3, 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, SMILES is CC(NC1=CC=CC(C(O2)=O)=C1C2=O)=O, in an article , author is Yu, Jin-Feng, once mentioned of 6296-53-3.

Cu-Mediated Amination of (Hetero)Aryl C-H bonds with NH Azaheterocycles

Direct synthesis of N-(hetero)arylated heteroarenes has been realized through Cu-mediated C-N coupling of NH azaheterocycles with aryl C-H bonds under aerobic conditions. This method features a broad scope of both heterocyclic arenes (pyridine, quinoline, pyrazole, imidazole, furan, thiophene, benzofuran, and indole) and NH azaheterocycles (imidazole, pyrazole, indole, azindole, purine, indazole, benzimidazole, pyridone, carbazole), providing a versatile method for the synthesis of pharmaceutically important N-(hetero)arylated heteroarenes. The versatility of this reaction was further demonstrated through late-stage modification of marketed drugs and the synthesis of a key intermediate for accessing a class of angiotensin II receptor 1 antagonists.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 6296-53-3, you can contact me at any time and look forward to more communication. Product Details of 6296-53-3.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 4412-91-3, Name is 3-Furanmethanol, molecular formula is C5H6O2, belongs to benzofurans compound. In a document, author is Ghosh, Debasis, introduce the new discover, Recommanded Product: 3-Furanmethanol.

Dihydrophthalazinediones accelerate amyloid beta peptide aggregation to nontoxic species

The production and accumulation of toxic amyloid plaques is one of the hallmarks of Alzheimer’s disease (AD). Amyloid beta (A beta) peptides undergo self-aggregation to form soluble oligomers, protofibrils and insoluble fibrils. This process is termed as amyloidogenesis and is a major contributor to the observed neuronal damage and memory impairment in the AD brain. Therefore, modulation of A beta aggregation process is considered to be an effective target to prevent neuronal damage under AD conditions. Modulation of amyloidogenesis involves inhibition of aggregation to form a toxic species or acceleration to drive the aggregation process to form species that are nontoxic by employing well-designed external ligands. In this context, we report a set of 2,3-dihydrophthalazine-1,4-dione (dihydrophthalazinedione, Phz) based small molecules (Phz 1-4) to modulate the A beta 42 aggregation and in cellular toxicity. Our detailed study (thioflavin T fluorescence assay, dot blot and transmission electron microscopy analysis) revealed fluorine containing Phz 4 as the potent modulator of A beta 42 aggregation by accelerating the process to form nontoxic aggregated species through hydrophobic and halogen interactions. A beta 42 aggregates formed in the presence of Phz 4 are mostly nontoxic when compared to the normal amyloid aggregates in the cellular milieu (PC12 cells). This study established that the hydrophobic and halogen interactions can be employed to develop anti-AD drug candidates. The excellent cell viability, effective modulation of A beta 42 aggregation to form nontoxic species and cellular (neuronal) rescue by Phz 4 offer a novel platform to develop therapeutic strategies for AD.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 4412-91-3. Recommanded Product: 3-Furanmethanol.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem