Category: benzofurans

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 591-11-7, Name is 5-Methylfuran-2(5H)-one, molecular formula is , belongs to benzofurans compound. In a document, author is Chen, Xiuli, Computed Properties of C5H6O2.

Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity

SIRT6 activation is thought to be a promising target for the treatment of many diseases, particularly cancer. Herein, we report the discovery of a series of new small-molecule SIRT6 activators. Structure-activity relationship analyses led to the identification of the most potent compound, 2-(1-benzofuran-2-yl)-N-(diphenylmethyl) quinoline-4-carboxamide (12q), which showed an EC1.5 value of 0.58 +/- 0.12 mu M and an EC50 value of 5.35 +/- 0.69 mu M against SIRT6-dependent peptide deacetylation in FLUOR DE LYS assay. It exhibited weak or no activity against other HDAC family members as well as 415 kinases, indicating good selectivity for SIRT6. 12q significantly inhibited the proliferation and migration of pancreatic ductal adenocarcinoma (PDAC) cells in vitro. It also markedly suppressed the tumor growth in a PDAC tumor xenograft model. This compound showed attractive pharmacokinetic properties. Overall, 12q could be a good lead compound for the treatment of PDAC, and it is worthy of further study.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is an experimental science, Formula: C11H11NO3, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 174775-48-5, Name is Ethyl 5-aminobenzofuran-2-carboxylate, molecular formula is C11H11NO3, belongs to benzofurans compound. In a document, author is Agarwal, Garima.

Structurally Modified Cyclopenta[b]benzofuran Analogues Isolated from Aglaia perviridis

Four new cyclopenta[b]benzofuran derivatives based on an unprecedented carbon skeleton (1-4), with a dihydrofuran ring fused to dioxanyl and aryl rings, along with a new structural analogue (5) of 5”’-episilvestrol (episilvestrol, 7), were isolated from an aqueous extract of a large-scale re-collection of the roots of Aglaia perviridis collected in Vietnam. Compound 5 demonstrated mutarotation in solution due to the presence of a hydroxy group at C-2”’, leading to the isolation of a racemic mixture, despite being purified on a chiral-phase HPLC column. Silvestrol (6) and episilvestrol (7) were isolated from the most potently cytotoxic chloroform subtraction of the roots. All new structures were elucidated using 1D and 2D NMR, HRESIMS, IR, UV, and ECD spectroscopic data. Of the five newly isolated compounds, only compound 5 exhibited cytotoxic activity against a human colon cancer (HT-29) and human prostate cancer cell line (PC-3), with IC50 values of 2.3 mu M in both cases. The isolated compounds (1-5) double the number of dioxanyl ring-containing rocaglate analogues reported to date from Aglaia species and present additional information on the structural requirements for cancer cell line cytotoxicity within this compound class.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 174775-48-5, in my other articles. Formula: C11H11NO3.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Huang, Xian, once mentioned the application of 6296-53-3, Application In Synthesis of N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4, molecular weight is 205.1669, MDL number is MFCD00453138, category is benzofurans. Now introduce a scientific discovery about this category.

(4+3) cycloadditions of allenyl ether-derived oxygen-stabilized oxyallyls with furans

(4 + 3) cycloadditions between allenyl ethers and furans are described. The reaction features an in situ formation of oxygen-stabilized oxyallyls via epoxidations of allenyl ethers in the presence of H2PO4-. The multiple interactions between the oxygen-stabilized oxyallyl species and H2PO4- were studied using DFT calculations for rationalization of the regio- and diastereoselectivity of this cycloaddition. The utilities of this cycloaddition have been demonstrated by converting the (4 + 3) cycloadduct into the cyclohepta[b]benzofuran skeleton of frondosin B in two steps.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products, Recommanded Product: 591-11-7, 591-11-7, Name is 5-Methylfuran-2(5H)-one, molecular formula is C5H6O2, belongs to benzofurans compound. In a document, author is Liu, Jian-Quan, introduce the new discover.

Silver-Mediated Synthesis of Substituted Benzofuran- and Indole-Pyrroles via Sequential Reaction of ortho-Alkynylaromatics with Methylene Isocyanides

A silver-mediated reaction between 2-ethynyl-3-(1-hydroxyprop-2-yn-1-yl)phenols or 2-ethyn-yl-3-(1-hydroxy-prop-2-yn-1-yl)anilines and methylene isocyanides has been developed. A sequential 5-endo-dig cyclization and [3 + 2] cycloaddition process is proposed. This synthetic strategy is atom- and step-efficient and applicable to a broad scope of substrates, allowing the synthesis of valuable substituted benzofuran- and indole-pyrroles in moderate to high yields.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 591-11-7. Recommanded Product: 591-11-7.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Reference of 497-23-4, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, belongs to benzofurans compound. In a article, author is Arcadi, Antonio, introduce new discover of the category.

Palladium-catalyzed Tsuji-Trost-type reaction of benzofuran-2-ylmethyl acetates with nucleophiles

The palladium-catalyzed benzylic-like nucleophilic substitution of benzofuran-2-ylmethyl acetate with N, S, O and C soft nucleophiles has been investigated. The success of the reaction is dramatically influenced by the choice of catalytic system: with nitrogen based nucleophiles the reaction works well with Pd-2(dba)(3)/dppf, while with sulfur, oxygen and carbo-nucleophiles [Pd(eta(3)-C3H5)Cl](2)/XPhos is more efficient. The regiochemical outcome shows that the nucleophilic substitution occurs only on the benzylic position of the eta(3)-(benzofuryl)methyl complex. The high to excellent yields and the simplicity of the experimental procedure make this protocol a versatile synthetic tool for the preparation of 2-substituted benzo[b]furans.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 174775-48-5, Name is Ethyl 5-aminobenzofuran-2-carboxylate, SMILES is O=C(C1=CC2=CC(N)=CC=C2O1)OCC, in an article , author is Megala, M., once mentioned of 174775-48-5, SDS of cas: 174775-48-5.

Heteroaromatic rings as linkers for quercetin-based dye-sensitized solar cell applications: a TDDFT investigation

The electronic properties of quercetin (Q)-pi-cyanoacrylic acid (CNA) dye molecules using heteroaromatic rings, namely cyclopentadiene (F1), furan (F2), pyrrole (F3), thiophene (F4), oxazole (F5), imidazole (F6), thiazole (F7), isoindene (FF1), benzofuran (FF2), indole (FF3), benzothiophene (FF4), benzoxazole (FF5), benzimidazole (FF6), and benzothiazole (FF7), as pi-linkers are studied for the first time using Time-Dependent Density Functional Theory (TDDFT) with dimethyl sulfoxide (DMSO) as solvent to predict their excitation energy, absorption wavelength, oscillator strength, light harvesting efficiency, and exciton binding energy. The charge transfer and charge regeneration in the ground and excited states of the dyes are established. The photon to electron energy transfer from the dye (quercetin) to the semiconductor (TiO2) surface is analyzed based on intramolecular charge transfer. The results of the electron transfer studies on these newly designed dyes could be used to enhance the performance of resulting dye-sensitized solar cells.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 497-23-4, Name is Furan-2(5H)-one, molecular formula is C4H4O2. In an article, author is Dias, Herbert J.,once mentioned of 497-23-4, Category: benzofurans.

Optimization of the Reaction Conditions for the Synthesis of Dihydrobenzofuran Neolignans

We have optimized the experimental conditions for the silver(I)-promoted oxidative coupling of methyl p-coumarate (I) and methyl ferulate (II), which is the most frequently used methodology to synthesize the bioactive dihydrobenzofuran neolignans 1 ((+/-)-trans-dehydrodicoumarate dimethyl ester) and 2 ((+/-)-trans-dehydrodiferulate dimethyl ester). Most of the tested conditions affected the conversion (i.e., the consumption of I and II) and the selectivity (i.e., the percentage of I and II that was converted into 1 and 2, respectively), so the optimized conditions were the ones that afforded the best balance between conversion and selectivity. Silver(I) oxide (0.5 equiv.) is the most efficient oxidant agent amongst the silver(I) reagents that were tested to convert methyl esters I and II into compounds 1 and 2, respectively. Acetonitrile, which has not yet been reported as a solvent for this reaction, provided the best balance between conversion and selectivity, besides being greener than other solvents that are more often employed (e.g., dichloromethane and benzene). Under the optimized conditions, the reaction time decreased from 20 to 4 h without significantly impacting the conversion and selectivity.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Li, Xiaoping, once mentioned the application of 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4, molecular weight is 205.1669, MDL number is MFCD00453138, category is benzofurans. Now introduce a scientific discovery about this category, Recommanded Product: 6296-53-3.

Enantioselective Synthesis of Benzofuran-Fused N-Heterocycles via Chiral Squaramide Catalyzed [4+2] Cyclization of Azadienes with Azlactones

An asymmetric cyclization reaction of azadienes and azlactones was investigated by employing a Cinchona squaramide catalyst, which could afford a series of benzofuran-fused six-membered heterocycles containing a alpha,alpha-disubstituted amino acid unit in a highly diastereoselective (>20:1 dr) and enantioselective (up to 99% ee) manner with good to excellent yields (up to 92%). A plausible pathway was proposed to explain the reaction process.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

87-41-2, Name is Isobenzofuran-1(3H)-one, molecular formula is C8H6O2, SDS of cas: 87-41-2, belongs to benzofurans compound, is a common compound. In a patnet, author is Zhao, Wenting, once mentioned the new application about 87-41-2.

Design, synthesis, and biological evaluation of novel 4H-chromen-4-one derivatives as antituberculosis agents against multidrug-resistant tuberculosis

A series of 4H-chromen-4-one derivatives obtained by scaffold morphing of the benzofuran compound, TAM16, were tested for antitubercular activity. Compound 8d was active against drug-sensitive and multidrug-resistant tuberculosis. A preliminary druggability evaluation showed that compound 8d displayed favorable mouse and human microsomal stability, low cytotoxicity, and acceptable oral bioavailability. An in vivo study indicated that compound 8d exhibited modest efficacy in an acute mouse model of TB after 3 weeks of treatment. Thus, 8d is a promising antituberculosis lead compound. (C) 2020 Elsevier Masson SAS. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 87-41-2 help many people in the next few years. SDS of cas: 87-41-2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Synthetic Route of 87-41-2, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 87-41-2, Name is Isobenzofuran-1(3H)-one, SMILES is O=C1OCC2=C1C=CC=C2, belongs to benzofurans compound. In a article, author is Liu, Fu-Jie, introduce new discover of the category.

Crystal structure of 4-(2-bromo-4-(6-morpholino-3-phenyl-3H-benzo[f]chromen-3-yl) cyclohexa-2, 5-dien-1-yl)morpholine, C33H31BrN2O

C31H31BrN2O3, monoclinic, P2(1)/c (no. 14), a = 10.2014(15) angstrom, b = 21.499(3) angstrom, c = 12.1885(18) angstrom, beta = 95.175(2)degrees, V = 2662.3(7) angstrom(3), Z = 4, R-gt (F) = 0.0521, wR(ref) (F-2) = 0.1993, T = 296(2) K.

Synthetic Route of 87-41-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 87-41-2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem