87-41-2, Name is Isobenzofuran-1(3H)-one, molecular formula is C8H6O2, SDS of cas: 87-41-2, belongs to benzofurans compound, is a common compound. In a patnet, author is Zhao, Wenting, once mentioned the new application about 87-41-2.
Design, synthesis, and biological evaluation of novel 4H-chromen-4-one derivatives as antituberculosis agents against multidrug-resistant tuberculosis
A series of 4H-chromen-4-one derivatives obtained by scaffold morphing of the benzofuran compound, TAM16, were tested for antitubercular activity. Compound 8d was active against drug-sensitive and multidrug-resistant tuberculosis. A preliminary druggability evaluation showed that compound 8d displayed favorable mouse and human microsomal stability, low cytotoxicity, and acceptable oral bioavailability. An in vivo study indicated that compound 8d exhibited modest efficacy in an acute mouse model of TB after 3 weeks of treatment. Thus, 8d is a promising antituberculosis lead compound. (C) 2020 Elsevier Masson SAS. All rights reserved.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 87-41-2 help many people in the next few years. SDS of cas: 87-41-2.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem