Category: benzofurans

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 174775-48-5, Name is Ethyl 5-aminobenzofuran-2-carboxylate, molecular formula is C11H11NO3. In an article, author is Jang, Hyo Jung,once mentioned of 174775-48-5, Category: benzofurans.

Colorimetric Detection of Co2+, Cu2+, and Zn2+ by a Multifunctional Chemosensor in Aqueous Solution

A novel multifunctional colorimetric sensor HMBC ((E)-3-((2-hydroxy-3-methoxybenzylidene)amino)benzofuran-2-carboxamide), based on 3-aminobenzofuran-2-carboxamide and 2-hydroxyl-3-methoxylbenzaldehyde, was designed and synthesized. The chemosensor HMBC could sense Co2+, Cu2+, and Zn2+ by color changes from colorless to yellow. Limits of detection (0.38, 0.41, and 1.02 mu M) of HMBC for Co2+, Cu2+, and Zn2+ were much lower than the New Jersey Department of Environmental Protection (NJDEP) standard (1.70 mu M) for Co2+ and the WHO guidelines (31.5 mu M and 76 mu M) for Cu2+ and Zn2+. Significantly, HMBC could be applied for the quantification of Co2+, Cu2+, and Zn2+ in real samples. The sensing process of HMBC for Co2+, Cu2+, and Zn2+ was well demonstrated by H-1 NMR and UV-Visible titrations, Job plots, theoretical calculations, and ESI-mass spectroscopy.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, HPLC of Formula: C10H7NO4, 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, SMILES is CC(NC1=CC=CC(C(O2)=O)=C1C2=O)=O, belongs to benzofurans compound. In a document, author is Maeno, Zen, introduce the new discover.

Efficient Synthesis of Benzofurans via Cross-Coupling of Catechols with Hydroxycoumarins Using O-2 as an Oxidant Catalyzed by AlPO4-Supported Rh Nanoparticle

An efficient synthesis of benzofuran derivatives via the cross-coupling of catechols and hydroxycoumarins in H2O using O-2 as an ideal oxidant is reported. The above reaction allows the direct use of substrates without prefunctionalization, involves formation of C-C and C-O bonds in cascade manner, and affords H2O as the sole by-product. This simple and clean reaction is achieved by the development of an AlPO4-supported Rh nanoparticle catalyst. The catalyst was applicable to the synthesis of a wide range of benzofurans. We also successfully utilized this catalytic method for total synthesis of flemichapparin C, one of the naturally occurring coumestans exhibiting bioactivity. The combined functions of Rh nanoparticles and AlPO4 play a key role in this reaction where in situ generated o-benzoquinone by Rh nanoparticles is possibly an intermediate for nucleophilic addition to hydroxycoumarins on AlPO4.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 6296-53-3. HPLC of Formula: C10H7NO4.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Zhu, Tianhan, once mentioned the application of 97148-39-5, Name is Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate, molecular formula is C7H10N2O4, molecular weight is 186.1653, MDL number is MFCD03791040, category is benzofurans. Now introduce a scientific discovery about this category, Recommanded Product: Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate.

Hydrodeoxygenation of Benzofuran over Bimetallic Ni-Cu/gamma-Al2O3 Catalysts

Bimetallic NixCu(10-x)/gamma-Al2O3 catalysts (where x is the mass fraction of Ni) with different Ni/Cu mass ratios were prepared. The catalysts were characterized by X-ray diffractometry, N-2 adsorption-desorption, inductively coupled plasma mass spectrometry, X-ray photoelectron spectroscopy, H-2-temperature programmed reduction, and transmission electron microscopy. The effect of Ni/Cu mass ratio on benzofuran hydrodeoxygenation was investigated in a fixed-flow reactor. Cu addition improved the NiO reducibility. The strong interaction of Ni and Cu led to the formation of smaller and highly dispersed CuO and NiO species over gamma-Al2O3, which favors an improvement in catalytic activity. Among the as-prepared catalysts, the Ni5Cu5/gamma-Al2O3 showed the highest deoxygenated product yield (79.9%) with an acceptable benzofuran conversion of 95.2%, which increased by 18.3% and 16.9% compared with that of the monometallic Ni/gamma-Al2O3 catalyst. A possible reaction network was proposed, which would provide insight into benzofuran hydrodeoxygenation over the Ni5Cu5/gamma-Al2O3 catalyst.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

97148-39-5, Name is Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate, molecular formula is C7H10N2O4, belongs to benzofurans compound, is a common compound. In a patnet, author is Siddiqui, Shaziyaparveen K., once mentioned the new application about 97148-39-5, Safety of Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate.

Discovery of 3-(benzofuran-2-ylmethyl)-1H-indole derivatives as potential autophagy inducers in cervical cancer cells

In this manuscript we have documented the identification of a novel anticancer scaffold 3-(benzofuran-2-yl-methyl)-1H-indole. This scaffold has been designed by tweaking the known bisindolylmethane scaffold of natural products that display a wide range of biological activities. A series of 24 new conjugates have been synthesized and among them 5 derivatives exhibited IC50 values less than 40 mu M against two cervical cancer cell lines SiHa and C33a. Further mechanistic studies of two compounds 3eb and 3ec revealed that the toxicity of these compounds was due to the effective induction of autophagy mediated cell death. The autophagy induction was confirmed by the progressive conversion of LC3I to LC3II and downregulation of p62 in cervical cancer cells.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Related Products of 497-23-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, belongs to benzofurans compound. In a article, author is Bisht, Narendra, introduce new discover of the category.

Pd(II)-Catalyzed, Bidentate Directing Group-aided Alkylation of sp(3)gamma-C-H Bonds: Access to 3-Alkylated Thiophene/Furan and Benzothiophene/Benzofuran Motifs

We report the Pd(II)-catalyzed bidentate directing group 8-aminoquinoline-aided sp(3)gamma-C-H alkylation of 3-methyl- thiophene/furan-2-carboxylic acid and 3-methyl- benzothiophene/benzofuran-2-carboxylic acid systems. While the 8-aminoquinoline-aided sp(3)gamma-C-H functionalization including arylation or amidation or amination of carboxylic acid derivatives are well known, however, the Pd(II)-catalyzed bidentate directing group 8-aminoquinoline-aided sp(3)gamma-C-H alkylation is not explored. Notably, 2- and/or 3-alkylated thiophene/furan and benzothiophene/benzofuran motifs are found in pharmaceutically active molecules. Accordingly, this work reveals the scope of the 8-aminoquinoline-aided sp(3)gamma-C-H alkylation method, and its usefulness by enriching the libraries of 3-alkylated thiophene/furan and benzothiophene/benzofuran motifs.

Related Products of 497-23-4, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 497-23-4.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Related Products of 87-41-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 87-41-2, Name is Isobenzofuran-1(3H)-one, SMILES is O=C1OCC2=C1C=CC=C2, belongs to benzofurans compound. In a article, author is Duncan, Luke F., introduce new discover of the category.

The Fragment-Based Development of a Benzofuran Hit as a New Class of Escherichia coli DsbA Inhibitors

A fragment-based drug discovery approach was taken to target the thiol-disulfide oxidoreductase enzyme DsbA from Escherichia coli (EcDsbA). This enzyme is critical for the correct folding of virulence factors in many pathogenic Gram-negative bacteria, and small molecule inhibitors can potentially be developed as anti-virulence compounds. Biophysical screening of a library of fragments identified several classes of fragments with affinity to EcDsbA. One hit with high mM affinity, 2-(6-bromobenzofuran-3-yl)acetic acid (6), was chemically elaborated at several positions around the scaffold. X-ray crystal structures of the elaborated analogues showed binding in the hydrophobic binding groove adjacent to the catalytic disulfide bond of EcDsbA. Binding affinity was calculated based on NMR studies and compounds 25 and 28 were identified as the highest affinity binders with dissociation constants (K-D) of 326 +/- 25 and 341 +/- 57 mu M respectively. This work suggests the potential to develop benzofuran fragments into a novel class of EcDsbA inhibitors.

Related Products of 87-41-2, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 87-41-2 is helpful to your research.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, in an article , author is Hu, Sha, once mentioned of 497-23-4, COA of Formula: C4H4O2.

TfOH-Catalyzed Cascade C-H Activation/Lactonization of Phenols with alpha-Aryl-alpha-diazoesters: Rapid Access to alpha-Aryl Benzofuranones

Aryl benzofuranones are privileged structural units present in natural products and pharmaceutically relevant compounds with high bioactivity and therapeutic value; synthetic access to these scaffolds remains an area of intensive interest. A new and efficient TfOH-catalyzed cascade ortho C-H activation/lactonization of phenols with alpha-aryl-alpha-diazoacetates is reported. This metal-free protocol provides an operationally simple and rapid method for the one-pot assembly of diverse alpha-aryl benzofuranones in high yields with broad substrate scope, a readily starting material, good chemo-regioselectivity, and excellent functional group compatibility.

Interested yet? Read on for other articles about 497-23-4, you can contact me at any time and look forward to more communication. COA of Formula: C4H4O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Reference of 14400-67-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, SMILES is O=C1C(C)OC(C)=C1, belongs to benzofurans compound. In a article, author is Li, Yiyang, introduce new discover of the category.

CHEMICAL COMPOSITIONS AND FUNCTIONS OF CHINESE FIR VOLATILES

Chinese fir is an important economic tree species in China. In addition to the application of alive trees and wood, the abundant chemical compositions of Chinese fir as a non-wood resource also have very important position. This study used Chinese fir wood powder as material, analyzing the chemical composition of Chinese fir volatiles by Fourier transform infrared spectroscopy (FT-IR), thermogravimetry (TG), pyrolisis-gas chromatography-mass spectrometry (Py-GC-MS), thermal desorption-gas chromatography-mass spectrometry (TD-GC-MS). Through the analysis of the detected we can know that volatiles main were phenolic (cedrol, alpha-bisabolol and beta-eudesmol), ester (dimethyl phthalate, diisobutyl phthalate and dibutyl phthalate), ketone (hydroxyacetone and benzofuran) and aldehyde (hexanal and nonanal) and so on. This compounds and their derivatives can use at wide medical, biology, cosmetics and textile industry.

Reference of 14400-67-0, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 14400-67-0 is helpful to your research.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Application In Synthesis of 3-Furanmethanol, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4412-91-3, Name is 3-Furanmethanol, molecular formula is C5H6O2. In an article, author is Liu, Yang-Zi,once mentioned of 4412-91-3.

Palladium-Catalyzed Asymmetric [4+3] Cyclization of Trimethylenemethane: Regio-, Diastereo-, and Enantioselective Construction of Benzofuro[3,2-b]azepine Skeletons

The palladium-catalyzed asymmetric [4+3] cyclization of trimethylenemethane donors with benzofuran-derived azadienes furnishes chiral benzofuro[3,2-b]azepine frameworks in high yields (up to 98 %) with exclusive regioselectivities and excellent stereoselectivities (up to >20:1 d.r., >99 % ee). This catalytic asymmetric [4+3] cyclization of Pd-trimethylenemethane can enrich the arsenal of Pd-TMM reactions in organic synthesis. In addition, this strategy provides an alternative approach to chiral azepines by a transition-metal-catalyzed asymmetric [4+3] cyclization.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Electric Literature of 497-23-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, belongs to benzofurans compound. In a article, author is Nguyen Tien Cong, introduce new discover of the category.

Synthesis, structure and in vitro cytotoxicity testing of some 2-aroylbenzofuran-3-ols

Five 2-aroyl-5-bromobenzo[b]furan-3-ol compounds (two of which are new) and four new 2-aroyl-5-iodobenzo[b]furan-3-ol compounds were synthesized starting from salicylic acid. The compounds were characterized by mass spectrometry and H-1 NMR and C-13 NMR spectroscopy. Single-crystal X-ray diffraction studies of four compounds, namely, (5-bromo-3-hydroxybenzofuran2-yl)(4-fluorophenyl)methanone, C15H8BrFO3, (5-bromo-3-hydroxybenzofuran2-yl)(4-chlorophenyl)methanone, C15H8BrClO3, (5-bromo-3-hydroxybenzofuran2-yl)(4-bromophenyl)methanone, C15H8Br2O3, and (4-bromophenyl)(3-hydroxy5-iodobenzofuran-2-yl)methanone, C15H8BrIO3, were also carried out. The compounds were tested for their in vitro cytotoxicity on the four human cancer cell lines KB, Hep-G2, Lu-1 and MCF7. Six compounds show good inhibiting abilities on Hep-G2 cells, with IC50 values of 1.39-8.03 mu M.

Electric Literature of 497-23-4, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 497-23-4.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem