Category: benzofurans

Chemistry is traditionally divided into organic and inorganic chemistry. Formula: C8H3FO3, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 652-39-1

Anaplastic lymphoma kinase (ALK) is a major target in treating non-small-cell lung cancer, and several ALK inhibitors have been developed to antagonize its kinase activity. However, patients treated with inhibitors ultimately develop drug resistance. Therefore, therapies with new mechanisms of action are needed. Proteolysis targeting chimeras (PROTACs) are molecules that comprise a ligand for binding a protein of interest (POI), a connecting linker and a ligand for recruiting E3 ligase, and cause degradation of the target POI. Here, the first multi-headed PROTAC, as a proof of concept, is developed as a gold nanoparticle (GNP)-based drug delivery system for delivering PROTACs to target ALK. Pegylated GNPs loaded with both ceritinib and pomalidomide molecules, termed Cer/Pom-PEG@GNPs, showed good stability in several media. The GNP conjugates potently decreased the levels of ALK fusion proteins in a dose- and time-dependent manner, and specifically inhibited the proliferation of NCI-H2228 cells. In comparison with small molecule PROTACs, the new multi-headed PROTAC promoted the formation of coacervates of POIs/multi-headed PROTAC/E3 ubiquitin ligases, and POI and E3 ubiquitin ligase interacted through multidirectional ligands and a flexible linker, thereby avoiding the need for complicated structure optimization of PROTACs. In conclusion, Cer/Pom-PEG@GNPs can degrade intracellular ALK fusion proteins with minor off-target toxicity and can be applied in patients resistant to ALK inhibitors. As a nano-based drug carrier, Cer/Pom-PEG@GNPs have the potential to enable prolonged circulation and specifically distribute drugs to tumor regions in vivo; thus, further investigation is warranted.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2562O – PubChem

Application of 4265-25-2, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Conference Paper, and a compound is mentioned, 4265-25-2, 2-Methylbenzofuran, introducing its new discovery.

The present work studies first the kinetics of the global primary thermal decomposition of raw waste lubricant oils in helium atmosphere conditions and with different proportions of helium:oxygen by TGA. In addition, pyrolysis and partial oxidation runs were carried out in a tubular reactor at 723 and 1123 K, where the volatiles and semivolatiles evolved were quantified by gas chromatography. TGA analysis shows nearly no difference between helium and helium-oxygen atmosphere, yielding no appreciable residue. Primary decomposition, which takes place between 450 and 700 K, can be modeled with two different processes: the main one (92.6% of the initial material) is an evaporation of the motor oil (with apparent zero order and a kinetic constant dependent on the mass and heating rate) and a small contribution of a typical solid carbonoceous pyrolysis. In the tubular reactor, gases evolved in pyrolysis at 773 K corroborate TG findings that the process is mainly an evaporation, with little changes with respect to the original chemical structure of the oil. Nevertheless, the gas composition changes completely in the presence of air, where the partial oxidation in the gas phase after evaporation yields lower chain paraffins and olefines. Gas evolution at 1123 K is completely different, yielding showing typical cracked flue gas composition: light gases with abundant olefins and poly-condensed aromatics.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 4265-25-2. In my other articles, you can also check out more blogs about 4265-25-2

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H117O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 4265-16-1, name is Benzo[b]furan-2-carboxaldehyde, introducing its new discovery. name: Benzo[b]furan-2-carboxaldehyde

Functionalized benzylic manganese chlorides were smoothly prepared by the direct insertion of magnesium into benzylic chlorides in the presence of MnCl2·2LiCl. Reactions with acid chlorides, aldehydes, an allyl bromide, and an enone proceed without any additional transition metal.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1008O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. SDS of cas: 13196-11-7, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 13196-11-7, name is Benzofuran-6-ol. In an article，Which mentioned a new discovery about 13196-11-7

The invention provides a compound of formula (I) indicated by the nucleoside phosphorus amide compound, and the compound as an anti-viral drug use. The invention of the formula (I) compound can inhibit the replication of virus RNA, can be used as a hepatitis c virus (HCV) NS5B polymerase inhibitors. The compounds of this invention having a NS5B polymerase inhibitory effect at the same time, its small hepatocyte toxicity. (by machine translation)

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H402O – PubChem

Electric Literature of 196799-45-8, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 196799-45-8, Name is 2,3-Dihydrobenzofuran-7-carbaldehyde,introducing its new discovery.

The present invention relates to 4,5-ring annulated indole derivatives, compositions comprising at least one 4,5-ring annulated indole derivatives, and methods of using the 4,5-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient. Wherein ring Z, of formula (I), is a cyclopentyl, cyclopentenyl, 5-membered heterocycloalkyl, 5-membered heterocycloalkenyl or 5-membered heteroaryl ring.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1289O – PubChem

4265-16-1, Name is Benzo[b]furan-2-carboxaldehyde, belongs to benzofurans compound, is a common compound. Recommanded Product: Benzo[b]furan-2-carboxaldehydeIn an article, once mentioned the new application about 4265-16-1.

Ligand-controlled non-decarbonylative and decarbonylative conversions of acyl fluorides were developed using a Pd(OAc)2/Et3SiH combination. When tricyclohexylphosphine (PCy3) was used as the ligand, aldehydes were obtained as simple reductive conversion products. The use of 1,2-bis(dicyclohexylphosphino)ethane (Cy2P(CH2)2PCy2, DCPE) as the ligand, however, favored the formation of hydrocarbons, which are decarbonylative reduction products.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H976O – PubChem

Electric Literature of 27404-31-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.27404-31-5, Name is 2-(Benzofuran-3-yl)ethanamine, molecular formula is C10H11NO. In a Article，once mentioned of 27404-31-5

The palladation reactions of 2-heteroaromatic primary phenethylamines bearing a benzofuran and benzothiophene nuclei have been studied. We have assessed the reactivity of the corresponding dimeric six-membered palladacycles (arising from C-H metalation) toward neutral ligands and unsaturated species. The insertion reactions of isocyanides into the Pd-C bond of the aforementioned palladacycles allowed the isolation of the corresponding iminoacyl intermediates, which could later be decomposed to give the amidine derivatives containing these relevant heterocyclic cores. In contrast, the carbonylation and alkenylation reactions led to straightforward formation of lactams and alkenylated organic derivatives. Interestingly, an unusual hydrogen-bond-promoted E-to-Z isomerization equilibrium of the resulting olefins was observed. Furthermore, we have studied the conditions to perform the alkenylation of the N-Boc derivatives of these substrates in a catalytic fashion. All the organometallic complexes (arising from the C-H activation of the heteroaromatic cores and insertion of isocyanides) and organic products (arising from the decomposition reactions) have been fully characterized, including the X-ray crystal structures of several organometallic and organic derivatives.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1605O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 4265-16-1, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 4265-16-1, name is Benzo[b]furan-2-carboxaldehyde. In an article，Which mentioned a new discovery about 4265-16-1

Chlorine-based disinfectants protect pool water from pathogen contamination but produce potentially harmful halogenated disinfection by-products (DBPs). This study characterized the bioaccumulation and elimination of exhaled DBPs post-swimming and investigated changes in exhaled breath profiles associated with chlorinated pool exposure. Nineteen participants provided alveolar-enriched breath samples prior to and 5, 90, 300, 510, and 600 minutes post-swimming. Known DBPs associated with chlorinated water were quantitated by thermal desorption-gas chromatography-mass spectrometry. Two distinct exhaled DBP elimination profiles were observed. Most participants (84%) reported peak concentrations immediately post-swimming that reduced exponentially. A sub-group exhibited a previously unobserved and delayed washout profile with peak levels at 90 minutes post-exposure. Metabolomic investigations tentatively identified two candidate biomarkers associated with swimming pool exposure, demonstrating an upregulation in the hours after exposure. These data demonstrated a hitherto undescribed exhaled DBP elimination profile in a small number of participants which contrasts previous findings of uniform accumulation and exponential elimination. This sub-group which exhibited delayed peak-exhaled concentrations suggests the uptake, processing, and immediate elimination of DBPs are not ubiquitous across individuals as previously understood. Additionally, non-targeted metabolomics highlighted extended buildup of compounds tentatively associated with swimming in a chlorinated pool environment that may indicate airway responses to DBP exposure.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H846O – PubChem

27404-31-5, Name is 2-(Benzofuran-3-yl)ethanamine, belongs to benzofurans compound, is a common compound. Product Details of 27404-31-5In an article, once mentioned the new application about 27404-31-5.

Strictosidine synthase catalyzes a Pictet-Spengler reaction in the first step in the biosynthesis of terpene indole alkaloids to generate strictosidine. The substrate requirements for strictosidine synthase are systematically and quantitatively examined and the enzymatically generated compounds are processed by the second enzyme in this biosynthetic pathway.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1603O – PubChem

Application of 90843-31-5, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 90843-31-5, 5-Acetyl-2,3-dihydrobenzo[b]furan, introducing its new discovery.

[Object] To provide a novel LXR.beta agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer’s disease. [Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2072O – PubChem