Category: benzofurans

Safety of Isobenzofuran-1(3H)-one. Authors Wang, CQ; Liu, G; Dou, GJ; Yang, Y; Chen, L; Ma, H; Jiang, ZY; Ma, HY; Li, CL; Li, L; Jiang, MD; Lu, QW; Li, P; Qi, HY in ELSEVIER GMBH published article about in [Wang, Chengqiang; Liu, Gen; Dou, Guojun; Yang, Yi; Chen, Lu; Ma, Hui; Jiang, Zhuyun; Ma, Haoyue; Li, Li; Qi, Hongyi] Southwest Univ, Coll Pharmaceut Sci, 2 Tiansheng Rd, Chongqing 400715, Peoples R China; [Wang, Chengqiang; Liu, Gen; Dou, Guojun; Yang, Yi; Chen, Lu; Ma, Hui; Jiang, Zhuyun; Ma, Haoyue; Li, Li; Qi, Hongyi] Southwest Univ, Coll Chinese Med, 2 Tiansheng Rd, Chongqing 400715, Peoples R China; [Li, Chenglong] Sichuan Prov Peoples Hosp, Dept Hematol, Chengdu 610212, Sichuan, Peoples R China; [Jiang, Mingdong; Lu, Qianwei; Li, Pan] Chongqing Ninth Peoples Hosp, Dept Oncol & Hematol, Jialing Village 69, Chongqing 400700, Peoples R China in 2021, Cited 24. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Background: Acute myeloid leukemia (AML) is a devastating hematologic malignancy with a high mortality. The nuclear receptors Nur77 and NOR-1 are commonly downregulated in human AML blasts and have emerged as key therapeutic targets for AML. Methods: This study aimed to identify Z-ligustilide (Z-LIG), the main phthalide of Rhizoma Chuanxiong, as a potential agent that can selectively target AML. The anti-AML activity of Z-LIG was evaluated in vitro and in vivo, and the effect and underlying mechanisms of Z-LIG on the restoration of Nur77 and NOR-1 was determined. Moreover, the role of Nur77 and NOR-1 in the regulation of Z-LIG-induced apoptosis and differentiation of AML cells was explored. Results: Z-LIG preferentially inhibited the viability of human AML cells, as well as suppressed the proliferation and colony formation ability. Notably, a concentration-dependent dual effect of Z-LIG was observed in AML cells: inducing apoptosis at relatively high concentrations (25 mu M to 100 mu M) and promoting differentiation at relatively low concentrations (10 mu M and 25 mu M). Importantly, Z-LIG restored Nur77 and NOR-1 expression in AML cells by increasing Ace-H3 (lys9/14) enrichment in their promoters. Meanwhile, Z-LIG enhanced the recruitment of p300 and reduced the recruitment of HDAC1, HDAC4/5/7, and MTA1 in the Nur77 promoter and enhanced the recruitment of p-CREB and reduced HDAC1 and HDAC3 in the NOR-1 promoter. Furthermore, Z-LIG-induced apoptosis was shown to be correlated with the mitochondria localization of Nur77/NOR-1 and subsequent Bcl-2 conformational change, converting Bcl-2 from a cyto-protective phenotype into a cyto-destructive phenotype. ZLIG-promoted differentiation was found to be related to Nur77/NOR-1-mediated myeloid differentiation-associated transcription factors Jun B, c-Jun, and C/EBP beta. Finally, silencing of Nur77 and NOR-1 attenuated anti-AML activity of Z-LIG in NOD/SCID mice. Conclusions: Our study suggests that Z-LIG may serve as a novel bifunctional agent for AML by restoring Nur77/NOR-1-mediated apoptosis and differentiation

Safety of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Wang, CQ; Liu, G; Dou, GJ; Yang, Y; Chen, L; Ma, H; Jiang, ZY; Ma, HY; Li, CL; Li, L; Jiang, MD; Lu, QW; Li, P; Qi, HY or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about NF-KAPPA-B; TNF-ALPHA PRODUCTION; HEME OXYGENASE-1; INNATE IMMUNITY; INFLAMMATION; PATHWAY; NRF2; MACROPHAGES; ACTIVATION; INDUCTION, Saw an article supported by the National Natural Science Funding of ChinaNational Natural Science Foundation of China (NSFC) [21977001]. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Chen, LZ; Wu, J; Li, K; Wu, QQ; Chen, R; Liu, XH; Ruan, BF. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one. Formula: C8H6O2

Phthalide is a promising chemical scaffold and has been proved to show potent anti-inflammatory efficacy. In this study, three series, total of 31 novel phthalide derivatives were designed and synthesized, their anti-inflammatory activities were screened in vitro and in vivo. The anti-inflammatory activity of all the compounds were screened on LPS induced NO production to evaluating their inhibitory effects. Structure-activity relationship has been concluded, and finally 3-((4-((4-ufluorobenzyl)oxy)phenyl)(-hydroxy)methyl)-5,7-dimethoxyisobenzofuran-1 (3H)-one (compound 9o) was found to be the active one with low toxicity, which showed 95.23% inhibitory rate at 10 mu M with IC50 value of 0.76 mu M against LPS-induced NO over expression. Preliminary mechanism studies indicated that compound 9o activated Nrf2/HO-1 signaling pathway via accumulation ROS and blocks the NF-kappa B/MAPK signaling pathway. The in vivo anti-inflammatory activity shown that compound 90 had obvious therapeutic effect against the adjuvant-induced rat arthritis model. (C) 2020 Elsevier Masson SAS. All rights reserved.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Chen, LZ; Wu, J; Li, K; Wu, QQ; Chen, R; Liu, XH; Ruan, BF or concate me.. Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Manganese catalyzed selective hydrogenation of cyclic imides to diols and amines WOS:000537870500006 published article about HOMOGENEOUS CATALYSIS; ALCOHOLS; EFFICIENT; AMIDES; KETONES; ESTERS; DESYMMETRIZATION; DEHYDROGENATION; MONOREDUCTION; REDUCTION in [Das, Uttam Kumar; Janes, Trevor; Kumar, Amit; Milstein, David] Weizmann Inst Sci, Dept Organ Chem, IL-76100 Rehovot, Israel; [Kumar, Amit] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland in 2020, Cited 43. Recommanded Product: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Herein we report the selective hydrogenation of cyclic imides to diols and amines, homogeneously catalyzed for the first time by a complex of an earth-abundant metal, a manganese pincer complex. A plausible catalytic cycle is proposed based on informative mechanistic experiments.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Das, UK; Janes, T; Kumar, A; Milstein, D or concate me.. Recommanded Product: 87-41-2

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Tseplin, EE; Tseplina, SN in ELSEVIER SCIENCE BV published article about AQUEOUS-SOLUTION; FLUORESCENCE; MOLECULES; DYNAMICS; URACIL in [Tseplin, Evgeniy E.; Tseplina, Svetlana N.] Russian Acad Sci, Ufa Fed Res Ctr, Inst Mol & Crystal Phys, Prospekt Oktyabrya 151, Ufa 450075, Russia in 2019, Cited 37. Recommanded Product: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

The optical absorption spectra of phthalide in polar (methanol) and nonpolar (n-hexane) solvents are recorded. The electronic phthalide spectrum was calculated by TDDFT B3LYP/6-311 + G(d, p) using the polarisable continuum model. Based on an analysis of calculation data and the displacement of absorption bands in a polar solvent, it was established that the absorption bands of phthalide at energies of 3.51 and 3.96 eV correspond to singlet-triplet transitions to the T-1 and T-2 states, respectively.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Tseplin, EE; Tseplina, SN or concate me.. Recommanded Product: 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recommanded Product: 87-41-2. Authors Shaalan, Y; Boulton, L; Jamieson, C in AMER CHEMICAL SOC published article about in [Shaalan, Youssef; Boulton, Lee] GlaxoSmithKline Med Res Ctr, Chem Dev, Stevenage SG1 2NY, Herts, England; [Shaalan, Youssef; Jamieson, Craig] Univ Strathclyde, Dept Pure & Appl Chem, Glasgow G1 1XL, Lanark, Scotland in 2020, Cited 39. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Ruthenium pincer complexes were synthesized and used for catalytic ester reductions under mild conditions (similar to 5 bar of hydrogen). An experimental design approach was used to optimize the conditions for yield, purity, and robustness. Evidence for the catalytically active ruthenium dihydride species is presented. Observed intermediates and side products, as well as time-course data, were used to build mechanistic insight. The optimized procedure was further demonstrated through scaled-up reductions of two pharmaceutically relevant esters, both in batch and continuous flow.

Recommanded Product: 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Shaalan, Y; Boulton, L; Jamieson, C or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Computed Properties of C8H6O2. Geiger, T; Haupt, A; Maichle-Mossmer, C; Schrenk, C; Schnepf, A; Bettinger, HF in [Geiger, Thomas; Haupt, Anne; Bettinger, Holger F.] Eberhard Karls Univ Tubingen, Inst Organ Chem, Morgenstelle 18, D-72076 Tubingen, Germany; [Maichle-Moessmer, Caecilia; Schrenk, Claudio; Schnepf, Andreas] Eberhard Karls Univ Tubingen, Inst Anorgan Chem, Morgenstelle 18, D-72076 Tubingen, Germany published Synthesis and Photodimerization of 2-and 2,3-Disubstituted Anthracenes: Influence of Steric Interactions and London Dispersion on Diastereoselectivity in 2019, Cited 84. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

There is increased evidence that the effect of bulky groups in organic, organometallic, and inorganic chemistry is not only repulsive but can be attractive because of London dispersion interactions. The influence of the size of primary alkyl substituents in 2- ‘ and 2,3-positions of anthracenes on the diastereoselectivity (anti vs syn dimer) of the [pi(4s) + pi(4s)] photoinduced dimerization is investigated. The synthesis of the anthracene derivatives was achieved by Suzuki-Miyaura reaction of 2,3-dibromoanthracene with alkylboronic acids as well as by reduction of anthraquinones that were obtained from 2,3-disubstituted 1,3-butadienes and naphthoquinone followed by dehydrogenation. The mixtures of dianthracene isomers were analyzed with respect to the anti/syn-ratio of the products by X-ray crystallography and nuclear Overhauser effect spectroscopy. While for the 2,3-dimethylanthracene the anti and syn isomers were formed in equal amounts, the anti dimers are the major products in all other cases. A linear correlation (R-2 = 0.98) between the steric size (Charton parameter) and the isomeric ratio suggests that the selectivity is dominated by classical repulsive steric effects. An exception is the iso-butyl substituent that produces an increased amount of the syn isomer. It is suggested that this is due to an exalted effect of London dispersion interactions.

Computed Properties of C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Geiger, T; Haupt, A; Maichle-Mossmer, C; Schrenk, C; Schnepf, A; Bettinger, HF or concate me.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Prodrug Strategies to Improve the Solubility of the HCV NS5A Inhibitor Pibrentasvir (ABT-530) WOS:000580558700022 published article about PROTEASE INHIBITORS; PHARMACOKINETICS; GLECAPREVIR; NUCLEOSIDE; DESIGN; SAFETY; SINGLE in [Randolph, John T.; Voight, Eric A.; Greszler, Stephen N.; Uno, Brice E.; Newton, James N.; Gleason, Kenneth M.; Stolarik, DeAnne; Van Handel, Cecilia; Bow, Daniel A. J.; DeGoey, David A.] Abbvie Inc, Global Pharmaceut Res & Dev, N Chicago, IL 60064 USA in 2020, Cited 26. Application In Synthesis of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

A research program to discover solubilizing prodrugs of the HCV NS5A inhibitor pibrentasvir (PIB) identified phosphomethyl analog 2 and trimethyl-lock (TML) prodrug 9. The prodrug moiety is attached to a benzimidazole nitrogen atom via an oxymethyl linkage to allow for rapid and complete release of the drug for absorption following phosphate removal by intestinal alkaline phosphatase. These prodrugs have good hydrolytic stability properties and improved solubility compared to PIB, both in aqueous buffer (pH 7) and FESSIF (pH 5). TML prodrug 9 provided superior in vivo performance, delivering high plasma concentrations of PIB in PK studies conducted in mice, dogs, and monkeys. The improved dissolution properties of these phosphate prodrugs provide them the potential to simplify drug dosage forms for PIB-containing HCV therapy.

Application In Synthesis of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Randolph, JT; Voight, EA; Greszler, SN; Uno, BE; Newton, JN; Gleason, KM; Stolarik, D; Van Handel, C; Bow, DAJ; DeGoey, DA or concate me.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Rapid Characterization of Chemical Components in Edible Mushroom Sparassis crispa by UPLC-Orbitrap MS Analysis and Potential Inhibitory Effects on Allergic Rhinitis WOS:000482998900037 published article about MASS-SPECTROMETRY; FATTY-ACIDS; A-D; LIQUID-CHROMATOGRAPHY; KINASE INHIBITOR; FRUITING BODY; IDENTIFICATION; ANTIOXIDANT; HANABIRATAKE; METABOLITES in [Wang, Zhixin; Zhong, Xiangjian; Li, Jinjie; Wang, Xin; Ji, Linlin; Shang, Xiaoya] Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Food, 191 Beitucheng West Rd, Beijing 100191, Peoples R China; [Liu, Jingyu] Shanxi Agr Univ, Coll Food Sci & Engn, 1 Mingxian South Rd, Jinzhong 030801, Taigu County, Peoples R China in 2019, Cited 108. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Recommanded Product: Isobenzofuran-1(3H)-one

Sparassis crispa is a kind of edible fungus widely grows in the north temperate zone, which shows various medicinal properties. Due to the complexity of chemical constitutes of this species, few investigations have acquired a comprehensive configuration for the chemical profile of it. In this study, a strategy based on ultra-high performance liquid chromatography (UPLC) combined with Orbitrap mass spectrometer (MS) was established for rapidly characterizing various chemical components in S. crispa. Through the summarized MS/MS fragmentation patterns of reference compounds and systematic identification strategy, a total of 110 components attributed to six categories were identified for the first time. Moreover, allergic rhinitis (AR) is a worldwide inflammatory disease seriously affecting human health, and the development of drugs to treat AR has been a topic of interest. It has been reported that the extracts of S. crispa showed obvious inhibitory effects on degranulation of mast cell- and allergen-induced IgE and proinflammatory mediators, but the active components and specific mechanism were still not clear. Src family kinases (SFKs) participate in the initial stage of allergy occurrence, which are considered the targets of AR treatment. Herein, on the basis of that self-built chemical database, virtual screening was applied to predict the potential SFKs inhibitors in S. crispa, using known crystal structures of Hck, Lyn, Fyn, and Syk as receptors, followed by the anti-inflammatory activity evaluation for screened hits by intracellular calcium mobilization assay. As results, sparoside A was directly confirmed to have strong anti-inflammatory activity with an IC50 value of 5.06 +/- 0.60 mu M. This study provides a useful elucidation for the chemical composition of S. crispa, and demonstrated its potential inhibitory effects on AR, which could promote the research and development of effective agents from natural resources.

Recommanded Product: Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Wang, ZX; Liu, JY; Zhong, XJ; Li, JJ; Wang, X; Ji, LL; Shang, XY or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry very interesting. Saw the article Quinine-derived thiourea promoted enantioselective Michael addition reactions of 3-substituted phthalides to maleimides published in 2019. COA of Formula: C8H6O2, Reprint Addresses Li, X (corresponding author), Nankai Univ, State Key Lab Elementoorgan Chem, Collaborat Innovat Ctr Chem Sci & Engn, Coll Chem, Tianjin 300071, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

A highly diastereoselective and enantioselective Michael addition/desymmetrization reaction of maleimides with prochiral 3- substituted phthalides catalyzed by quinine-derived bifunctional thiourea was realized. A broad range of the 3,3-disubstituted phthalides bearing vicinal quaternary-tertiary stereogenic centers were synthesized in moderate to good yields (up to 96%) with high diastereoselectivities (up to >19:1 dr) and enantioselectivities (up to 96:4 er).

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Wang, J; Li, X; Cheng, JP or concate me.. COA of Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry very interesting. Saw the article The Effect of Packing Material Properties on Tars Removal by Plasma Catalysis published in 2020. Quality Control of Isobenzofuran-1(3H)-one, Reprint Addresses Cimerman, R (corresponding author), Comenius Univ, Fac Math Phys & Informat, Dept Astron Phys Earth & Meteorol, Mlynska Dolina F2, Bratislava 84248, Slovakia.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Plasma catalysis has been utilized in many environmental applications for removal of various hydrocarbons including tars. The aim of this work was to study the tars removal process by atmospheric pressure DBD non-thermal plasma generated in combination with packing materials of various composition and catalytic activity (TiO2, Pt/gamma Al2O3, BaTiO3, gamma Al2O3, ZrO2, glass beads), dielectric constant (5-4000), shape (spherical and cylindrical pellets and beads), size (3-5 mm in diameter, 3-8 mm in length), and specific surface area (37-150 m(2)/g). Naphthalene was chosen as a model tar compound. The experiments were performed at a temperature of 100 degrees C and a naphthalene initial concentration of approx. 3000 ppm, i.e., under conditions that are usually less favorable to achieve high removal efficiencies. For a given specific input energy of 320 J/L, naphthalene removal efficiency followed a sequence: TiO2 > Pt/gamma Al2O3 > ZrO2 > gamma Al2O3 > glass beads > BaTiO3 > plasma only. The efficiency increased with the increasing specific surface area of a given packing material, while its shape and size were also found to be important. By-products of naphthalene decomposition were analyzed by means of FTIR spectrometry and surface of packing materials by SEM analysis.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Cimerman, R; Cibikova, M; Satrapinskyy, L; Hensel, K or concate me.. Quality Control of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem