Category: benzofurans

Capolupo, M; Sorensen, L; Jayasena, KD; Booth, AM; Fabbri, E in [Capolupo, Marco; Jayasena, Kongalage Don Ranil; Fabbri, Elena] Univ Bologna, Dept Biol Geol & Environm Sci, Via St Alberto 163, I-48123 Ravenna, Italy; [Sorensen, Lisbet; Booth, Andy M.] SINTEF Ocean Environm & New Resources, Postboks 4762, N-7465 Trondheim, Norway published Chemical composition and ecotoxicity of plastic and car tire rubber leachates to aquatic organisms in 2020, Cited 66. Product Details of 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Synthetic polymer-based materials are ubiquitous in aquatic environments, where weathering processes lead to their progressive fragmentation and the leaching of additive chemicals. The current study assessed the chemical content of freshwater and marine leachates produced from car tire rubber (CTR), polypropylene (PP), polyethylene terephthalate (PET), polystyrene (PS) and polyvinyl chloride (PVC) microplastics, and their adverse effects on the microalgae Raphidocelis subcapitata (freshwater) and Skeletonema costatum (marine) and the Mediterranean mussel Mytilus galloprovincialis. A combination of non-target and target chemical analysis revealed a number of organic and metal compounds in the leachates, including representing plasticizers, antioxidants, antimicrobials, lubricants, and vulcanizers. CTR and PVC materials and their corresponding leachates had the highest content of tentatively identified organic additives, while PET had the lowest. The metal content varied both between polymer leachates and between freshwater and seawater. Notable additives identified in high concentrations were benzothiazole (CTR), phthalide (PVC), acetophenone (PP), cobalt (CTR, PET), zinc (CTR, PVC), lead (PP) and antimony (PET). All leachates, except PET, inhibited algal growth with EC50 values ranging from 0.5% (CTR) and 64% (PP) of the total leachate concentration. Leachates also affected mussel endpoints, including the lysosomal membrane stability and early stages endpoints as gamete fertilization, embryonic development and larvae motility and survival. Embryonic development was the most sensitive parameter in mussels, with EC50 values ranging from 0.8% (CTR) to 65% (PET) of the total leachate. The lowest impacts were induced on D-shell larvae survival, reflecting their ability to down-regulate motility and filtration in the presence of chemical stressors. This study provides evidence of the relationship between chemical composition and toxicity of plastic/rubber leachates. Consistent with increasing contamination by organic and inorganic additives, the leachates ranged from slightly to highly toxic to mussels and algae, highlighting the need for a better understanding of the overall impact of plastic-associated chemicals on aquatic ecosystems. (C) 2019 The Authors. Published by Elsevier Ltd.

Product Details of 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Capolupo, M; Sorensen, L; Jayasena, KD; Booth, AM; Fabbri, E or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Modular Synthetic Approach to Silicon-Rhodamine Homologues and Analogues via Bis-aryllanthanum Reagents WOS:000637002800039 published article about FLUORESCENT-PROBES; CELL; FLUOROPHORE; MICROSCOPY in [Butkevich, Alexey N.] Max Planck Inst Med Res, Dept Opt Nanoscopy, D-69120 Heidelberg, Germany in 2021, Cited 41. SDS of cas: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

A modular synthetic approach toward diverse analogues of the far-red fluorophore silicon-rhodamine (SiR), based on a regioselective double nucleophilic addition of aryllanthanum reagents to esters, anhydrides, and lactones, is proposed. The reaction has improved functional group tolerance and represents a unified strategy toward cell-permeant, spontaneously blinking, and photoactivatable SiR fluorescent labels. In tandem with Pd-catalyzed hydroxy- or aminocarbonylation, it serves a streamlined synthetic pathway to a series of validated live-cell-compatible fluorescent dyes.

SDS of cas: 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Butkevich, AN or concate me.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Category: benzofurans. I found the field of Environmental Sciences & Ecology very interesting. Saw the article Changes in ecotoxicity of naphthalene and alkylated naphthalenes during photodegradation in water published in 2019, Reprint Addresses Kwon, JH (corresponding author), Korea Univ, Div Environm Sci & Ecol Engn, 145 Anam Ro, Seoul 02841, South Korea.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.

Crude oil released into the environment contains many polycyclic aromatic hydrocarbons (PAHs). Alkylated PAHs are more abundant than unsubstituted PAHs and their toxicity is also of serious concern. Among the various physical, chemical, and biological weathering processes of crude oils, photodegradation is one of the most important for determining the environmental fate of oil residues. In this study, the photodegradation rate constants of naphthalene and alkylated naphthalenes were determined under simulated laboratory conditions at different temperature. Changes in the luminescence inhibition of Aliivibrio fischeri, as an indicator of the baseline toxicity, were observed in photodegradation mixtures. The major transformation products were also identified by gas chromatography-mass spectrometry. The photodegradation of naphthalene and the eight alkylated naphthalenes was described well by pseudofirst-order kinetics regardless of experimental temperature. The measured toxicity of the reaction mixtures obtained by photodegradative weathering slightly increased initially and then decreased with further weathering. In all cases, the observed toxicity was greater than accounted for by the parent compounds, indicating that the photodegradation products also contributed significantly to the overall toxicity of the mixtures. The identified photodegradation products were mostly oxygenated compounds such as alcohols, aldehydes, ketones, and quinones, which warrant further investigation. (C) 2019 Elsevier Ltd. All rights reserved.

Category: benzofurans. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Kang, HJ; Jung, Y; Kwon, JH or concate me.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Tian, MQ; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Muller, CE in [Tian, Maoqun; Abdelrahman, Aliaa; Azazna, Djamil; Spanier, Claudia; Densborn, Sabrina; Hinz, Sonja; Mueller, Christa E.] Univ Bonn, PharmaCtr Bonn, Pharmaceut Inst, Pharmaceut & Med Chem, D-53121 Bonn, Germany; [Baqi, Younis] Sultan Qaboos Univ, Dept Chem, Fac Sci, Muscat 123, Oman; [Fuentes, Eduardo] Univ Talca, Dept Clin Biochem & Immunohaematol, Thrombosis Res Ctr, Med Technol Sch,Fac Hlth Sci,Interdisciplinary Ct, Talca 3460000, Chile; [Schmid, Ralf] Univ Leicester, Dept Mol & Cell Biol, Leicester LE1 7RH, Leics, England; [Schmid, Ralf] Univ Leicester, Leicester Inst Struct & Chem Biol, Leicester LE1 7RH, Leics, England published Discovery and Structure Relationships of Salicylanilide Derivatives as Potent, Non-acidic P2X1 Receptor Antagonists in 2020, Cited 78. Product Details of 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Antagonists for the ATP-gated ion channel receptor P2X1 have potential as antithrombotics and for treating hyperactive bladder and inflammation. In this study, salicylanilide derivatives were synthesized based on a screening hit. P2X1 antagonistic potency was assessed in 1321N1 astrocytoma cells stably transfected with the human P2X1 receptor by measuring inhibition of the ATP-induced calcium influx. Structure-activity relationships were analyzed, and selectivity versus other P2X receptor subtypes was assessed. The most potent compounds, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide (1, IC50 0.0192 mu M) and N-[3,5-bis(trifluoromethyl)phenyl]-4-chloro-2-hydroxybenzamide (14, IC50 0.0231 mu M), displayed >500-fold selectivity versus P2X2 and P2X3, and 10-fold selectivity versus P2X4 and P2X7 receptors, and inhibited collagen-induced platelet aggregation. They behaved as negative allosteric modulators, and molecular modeling studies suggested an extracellular binding site. Besides selective P2X1 antagonists, compounds with ancillary P2X4 and/or P2X7 receptor inhibition were discovered. These compounds represent the first potent, non-acidic, allosteric P2X1 receptor antagonists reported to date.

Product Details of 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Tian, MQ; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Muller, CE or concate me.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Formula: C8H6O2. In 2019 RES CHEM INTERMEDIAT published article about BIOLOGICAL EVALUATION; DERIVATIVES; HYDRAZONES; DESIGN in [Alifu, Zulipiye; Nizhamu, Maijidan; Ablajan, Keyume] Xinjiang Univ, Key Lab Oil & Gas Fine Chem, Minist Educ & Xinjiang Uyghur Autonomous Reg, Coll Chem & Chem Engn, Urumqi 830046, Peoples R China in 2019, Cited 22. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

We report an efficient, catalyst-free, one-pot synthesis of (E)-N ‘-benzylidene-2-(hydroxymethyl)benzohydrazide derivatives by the one-pot reaction of phthalide, hydrazine hydrate and aldehyde. Advantages of this synthetic approach include mild reaction conditions and environmentally friendly nature, and the ability to provide a wide range of desired compounds in moderate to excellent yields. Graphic abstract Here we introduce a green and efficient one-pot three-component protocol for the synthesis of (E)-N ‘-benzylidene-2-(hydroxymethyl)benzohydrazide derivatives in ethanol without any catalyst. [GRAPHICS] .

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Alifu, Z; Nizhamu, M; Ablajan, K or concate me.. Formula: C8H6O2

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Computed Properties of C8H6O2. I found the field of Chemistry very interesting. Saw the article An Entry to Enantioenriched 3,3-Disubstituted Phthalides through Asymmetric Phase-Transfer-Catalyzed gamma-Alkylation Marina published in 2020, Reprint Addresses Della Sala, G (corresponding author), Univ Salerno, Dipartimento Chim & Biol Zambelli, I-84084 Fisciano, SA, Italy.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.

A novel asymmetric phase-transfer-catalyzed gamma-alkylation of phthalide 3-carboxylic esters has been developed, giving access to 3,3-disubstituted phthalide derivatives, which present a chiral quaternary gamma-carbon in good to excellent yields and good enantioselectivities (74-88% ee). The enantiomeric purity could be substantially enhanced to 94-95% ee by recrystallization. Both electron-withdrawing and electron-releasing substituents are well tolerated on the phthalide core as well as on the aromatic moiety of the alkylating agent. This methodology, enabling the introduction of an unfunctionalized group at the phthalide gamma-position, fully complements previously reported organocatalytic strategies involving functionalized electrophiles, thus expanding the scope of accessible 3,3-disubstituted products. The high synthetic value of this asymmetric reaction has been proven by the formal synthesis of the naturally occurring alkaloid (+)-(9S,13R)-13-hydroxyisocyclocelabenzine.

Computed Properties of C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Sicignano, M; Schettini, R; Pierri, G; Marino, ML; Izzo, I; De Riccardis, F; Bernardi, L; Della Sala, G or concate me.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recommanded Product: Isobenzofuran-1(3H)-one. In 2019 ORG PROCESS RES DEV published article about OXIDANT-FREE OXIDATION; CARBOXYLIC-ACID SALTS; ASTERISK-IR COMPLEX; SECONDARY ALCOHOLS; HOMOGENEOUS RUTHENIUM; HYDROGEN-PRODUCTION; N-ALKYLATION; ACCEPTORLESS; PALLADIUM; LIGAND in [Mori, Takamichi] Sanyo Onoda City Univ, Fac Engn, Dept Appl Chem, 1-1-1 Daigakudori, Yamaguchi 7560884, Japan; [Ishii, Chihiro; Kimura, Masanari] Nagasaki Univ, Grad Sch Engn, 1-14 Bunkyo Machi, Nagasaki 8528521, Japan in 2019, Cited 63. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

A dehydrogenative oxidation reaction of primary alcohols to aldehydes catalyzed by a simple Pd/Xantphos catalytic system was developed under an argon or nitrogen atmosphere without oxidizing agents or hydrogen acceptors. The reaction product could be easily changed: under aerobic conditions, esters were obtained in aprotic solvents, whereas the corresponding carboxylic acids were produced in aqueous media. These oxidizing processes were applicable to the efficient synthesis of useful nitrogen-containing heterocyclic compounds such as indole, quinazoline, and benzimidazole via intramolecular versions of this reaction from amino alcohols.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Shaalan, Y; Boulton, L; Jamieson, C in AMER CHEMICAL SOC published article about in [Shaalan, Youssef; Boulton, Lee] GlaxoSmithKline Med Res Ctr, Chem Dev, Stevenage SG1 2NY, Herts, England; [Shaalan, Youssef; Jamieson, Craig] Univ Strathclyde, Dept Pure & Appl Chem, Glasgow G1 1XL, Lanark, Scotland in 2020, Cited 39. Category: benzofurans. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Ruthenium pincer complexes were synthesized and used for catalytic ester reductions under mild conditions (similar to 5 bar of hydrogen). An experimental design approach was used to optimize the conditions for yield, purity, and robustness. Evidence for the catalytically active ruthenium dihydride species is presented. Observed intermediates and side products, as well as time-course data, were used to build mechanistic insight. The optimized procedure was further demonstrated through scaled-up reductions of two pharmaceutically relevant esters, both in batch and continuous flow.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Shaalan, Y; Boulton, L; Jamieson, C or concate me.. Category: benzofurans

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Dai, Y; Li, KL; She, JL; Zeng, YB; Wang, H; Liao, SR; Lin, XP; Yang, B; Wang, JF; Tao, HM; Dai, HF; Zhou, XF; Liu, YH in [Dai, Yu; Li, Kunlong; She, Jianglian; Liao, Shengrong; Lin, Xiuping; Yang, Bin; Wang, Junfeng; Zhou, Xuefeng; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Peoples R China; [Li, Kunlong; Liao, Shengrong; Lin, Xiuping; Yang, Bin; Wang, Junfeng; Zhou, Xuefeng; Liu, Yonghong] Southern Marine Sci & Engn Guangdong Lab Guangzho, Guangzhou 511458, Peoples R China; [Zeng, Yanbo; Wang, Hao; Dai, Haofu] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Res & Dev Nat Prod Li Folk Med, Haikou 571101, Hainan, Peoples R China; [Tao, Huaming] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Peoples R China; [Liu, Yonghong] Shenyang Pharmaceut Univ, Wuya Coll Innovat, Shenyang 110016, Peoples R China published Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus Cochliobolus Lunatus SCSIO41401 in 2020, Cited 21. Computed Properties of C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

A pair of novel lipopeptide epimers, sinulariapeptides A (1) and B (2), and a new phthalide glycerol ether (3) were isolated from the marine algal-associated fungus Cochliobolus lunatus SCSIO41401, together with three known chromanone derivates (4-6). The structures of the new compounds, including the absolute configurations, were determined by comprehensive spectroscopic methods, experimental and calculated electronic circular dichroism (ECD), and Mo-2 (OAc)(4)-induced ECD methods. The new compounds 1-3 showed moderate inhibitory activity against acetylcholinesterase (AChE), with IC50 values of 1.3-2.5 mu M, and an in silico molecular docking study was also performed.

Computed Properties of C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Dai, Y; Li, KL; She, JL; Zeng, YB; Wang, H; Liao, SR; Lin, XP; Yang, B; Wang, JF; Tao, HM; Dai, HF; Zhou, XF; Liu, YH or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry very interesting. Saw the article Quinine-derived thiourea promoted enantioselective Michael addition reactions of 3-substituted phthalides to maleimides published in 2019. COA of Formula: C8H6O2, Reprint Addresses Li, X (corresponding author), Nankai Univ, State Key Lab Elementoorgan Chem, Collaborat Innovat Ctr Chem Sci & Engn, Coll Chem, Tianjin 300071, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

A highly diastereoselective and enantioselective Michael addition/desymmetrization reaction of maleimides with prochiral 3- substituted phthalides catalyzed by quinine-derived bifunctional thiourea was realized. A broad range of the 3,3-disubstituted phthalides bearing vicinal quaternary-tertiary stereogenic centers were synthesized in moderate to good yields (up to 96%) with high diastereoselectivities (up to >19:1 dr) and enantioselectivities (up to 96:4 er).

COA of Formula: C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Wang, J; Li, X; Cheng, JP or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem