Computed Properties of C8H6O2. I found the field of Chemistry very interesting. Saw the article An Entry to Enantioenriched 3,3-Disubstituted Phthalides through Asymmetric Phase-Transfer-Catalyzed gamma-Alkylation Marina published in 2020, Reprint Addresses Della Sala, G (corresponding author), Univ Salerno, Dipartimento Chim & Biol Zambelli, I-84084 Fisciano, SA, Italy.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.
A novel asymmetric phase-transfer-catalyzed gamma-alkylation of phthalide 3-carboxylic esters has been developed, giving access to 3,3-disubstituted phthalide derivatives, which present a chiral quaternary gamma-carbon in good to excellent yields and good enantioselectivities (74-88% ee). The enantiomeric purity could be substantially enhanced to 94-95% ee by recrystallization. Both electron-withdrawing and electron-releasing substituents are well tolerated on the phthalide core as well as on the aromatic moiety of the alkylating agent. This methodology, enabling the introduction of an unfunctionalized group at the phthalide gamma-position, fully complements previously reported organocatalytic strategies involving functionalized electrophiles, thus expanding the scope of accessible 3,3-disubstituted products. The high synthetic value of this asymmetric reaction has been proven by the formal synthesis of the naturally occurring alkaloid (+)-(9S,13R)-13-hydroxyisocyclocelabenzine.
Computed Properties of C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Sicignano, M; Schettini, R; Pierri, G; Marino, ML; Izzo, I; De Riccardis, F; Bernardi, L; Della Sala, G or concate me.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem