Category: benzofurans

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Pharmacokinetics of certain drugs in the domesticated goat.Related Products of 129-18-0.

Kinetic values for the half-life, first order disappearance rate constant, and apparent specific volume of distribution were reported for acidic drugs (salicylate [69-72-7], phenylbutazone [50-33-9], pentobarbital [57-33-0], and sulfanilamide [63-74-1]) and basic drugs (antipyrine [60-80-0], quinine [130-95-0], and tolazoline [59-98-3]) in goats. The protein-binding capacity was determined for each drug, since membrane permeability is influenced by this factor as well as by the drug’s physicochem. characteristics.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Recommanded Product: 90866-33-4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Asymmetric synthesis of (+)-negamycin. Author is Davies, Stephen G.; Ichihara, Osamu.

(+)-Negamycin was synthesized employing the highly diastereoselective conjugate addition of lithium (α-methylbenzyl)benzylamide in the key step. The synthesis was completed in 13 steps starting from Et 4-chloroacetoacetate with an overall yield of 24%.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Fluoronicotinonitrile, is researched, Molecular C6H3FN2, CAS is 3939-12-6, about Concise Synthesis of Furo[2,3-b]indolines via [3,3]-Sigmatropic Rearrangement of N-Alkenyloxyindoles, the main research direction is furoindoline preparation; alkenyloxyindole sigmatropic rearrangement.Quality Control of 6-Fluoronicotinonitrile.

A concise new synthetic route to furo[2,3-b]indolines has been developed by taking advantage of the reactivity of N-alkenyloxyindole intermediates. These compounds spontaneously underwent [3,3]-sigmatropic rearrangement followed by cyclization to form hemiaminals as single diastereomers. Tin-promoted N-hydroxyindole formation followed by conjugate addition to activated alkynes provides simple and modular access to a diverse array of N-alkenyloxyindoles and their corresponding furo[2,3-b]indolines. Microscale high-throughput experimentation was used to facilitate investigation of the scope and tolerance of this transformation and related studies on the nucleophilic aromatic substitution and rearrangement of N-hydroxyindoles with halogenated arenes have also been evaluated.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

57830-14-5, 5-Phenoxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,57830-14-5

102351 A reactor was charged with toluene (24 Kg), and stirring was initiated. The reactor was then charged with 5-phenoxyphthalide (56 Kg), thionyl chloride (41 Kg), trimethyl borate (1 Kg), dichlorotriphenylphosphorane (2.5 Kg), and potassium carbonate (77 Kg). The mixture was heated to reflux until reaction completion and solvent was removed leaving 2-chloromethyl-4-phenoxybenzoylchloride. Methanol was charged and the mixture was heated above 50 C until reaction completion. Solvent was removed and replaced with DMF. This solution of the product methyl 2-chloromethyl-4- phenoxybenzoic acid methyl ester in DMF was used directly in the next step (HPLC: 85%).

57830-14-5 5-Phenoxyisobenzofuran-1(3H)-one 44558580, abenzofuran compound, is more and more widely used in various fields.

Reference：
Patent; FIBROGEN, INC.; THOMPSON, Michael D.; PARK, Jung Min; AREND, Michael P.; WO2014/14834; (2014); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

1646-26-0, 2-Acetylbenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of acetophenone (100 mg, 1 equiv) or phenylacetylene (1 equiv) in dioxane (5 mL), Oxone (2 equiv) and TFA (2 equiv) were added. The mixture was then heated to reflux for 10 h and then cooled to r.t. H2O (10 mL) was added and the mixture was extracted with EtOAc (2 × 20 mL). The combined organic layers were treated with sat. NaHCO3 solution and the aqueous layer was poured onto crushed ice and treated with 2 M HCl; a colorless solid precipitated out. The precipitate was filtered off and dried in vacuo to give benzoic acid (3a) after column chromatography (silica gel; EtOAc-hexane, 1:9) as a white crystalline solid; yield: 0.096 g (95%) from 1a; mp 122-123 C.

1646-26-0, 1646-26-0 2-Acetylbenzofuran 15435, abenzofuran compound, is more and more widely used in various fields.

Reference：
Article; Aravinda Kumar; Venkateswarlu, Vunnam; Vishwakarma, Ram A.; Sawant, Sanghapal D.; Synthesis; vol. 47; 20; (2015); p. 3161 – 3168;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57830-14-5,5-Phenoxyisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

To a solid mixture of 5-phenoxy-3H-isobenzofuran-l-one (65.54 g, 0.29 mol), boric acid (538 mg, 8.7 mmol) and triphenylphosphine oxide (2.42 g, 8.7 mmol) was added thionyl chloride (42.3 mL). The resulting mixture was refluxed overnight. After cooled, methanol (300 mL) was slowly added to the reaction mixture. It was then refluxed for 1 h and concentrated. Residue was partitioned between EtOAc and saturated NaHC03 solution. The organic layer was washed with brine, dried over Na2S04, filtered and concentrated to provide the title compound (87.02 g, 0.31 mol) as an oil. It was used directly to the next reaction without further purification. lH NMR in CDCI3, delta in ppm: 7.91 (d, 1 H, 8.6 Hz), 7.5-6.9 (m, 7 H), 5.06 (s, 2 H), 3.83 (s, 3 H)., 57830-14-5

The synthetic route of 57830-14-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; FIBROGEN, INC.; HO, Wen-Bin; ZHAO, Hongda; DENG, Shaojiang; NG, Danny; WRIGHT, Lee R.; WU, Min; ZHOU, Xiaoti; AREND, Michael P.; FLIPPIN, Lee A.; WO2013/134660; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

57830-14-5, 5-Phenoxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57830-14-5, 5-phenoxyisobenzofuran-1(3H)-one (1.0g, 4.42mmol), xylene 10mL, benzyl triethyl ammonium chloride (300 mg, 1.32 mmol) and boron trifluoride diethyl ether (200 mg, 1.41 mmol) were added to the reaction flask, and the mixture was heated to 100 C dropwise to add thionyl chloride (5.0 g, 42.03 mmol). The reaction was carried out at 135 C for 5 hours. After the reaction was completed by thin layer chromatography, the filtrate was concentrated under reduced pressure. The filtrate was concentrated to 3 mL of methanol. The mixture was stirred at 55 C for 1 hour, then concentrated to dryness under reduced pressure. The potassium carbonate solution and the sodium chloride solution were washed and concentrated to dryness to give the title compound 2c (1.0 g, 83.0%).Used directly in the next step.

As the paragraph descriping shows that 57830-14-5 is playing an increasingly important role.

Reference：
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Cai Jiaqiang; Xie Yinong; You Zejin; Song Changwei; Zhang Jichao; Li Lu; Zhang Qiaoling; Wang Yongqiang; Chen Xing; Jiao Shihu; Li Youqiang; Wang Tao; Zeng Hong; Song Hongmei; Ye Qijun; Su Donghai; Zhou Xin; Zhang Shaohua; Wang Lichun; Wang Jingyi; (122 pag.)CN108341777; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57830-14-5,5-Phenoxyisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

To a solid mixture of 5-phenoxy-3H-isobenzofuran-l-one (65.54 g, 0.29 mol), boric acid (538 mg, 8.7 mmol) and triphenylphosphine oxide (2.42 g, 8.7 mmol) was added thionyl chloride (42.3 mL). The resulting mixture was refluxed overnight. After cooled, methanol (300 mL) was slowly added to the reaction mixture. It was then refluxed for 1 h and concentrated. Residue was partitioned between EtOAc and saturated NaHC03 solution. The organic layer was washed with brine, dried over Na2S04, filtered and concentrated to provide the title compound (87.02 g, 0.31 mol) as an oil. It was used directly to the next reaction without further purification. lH NMR in CDCI3, delta in ppm: 7.91 (d, 1 H, 8.6 Hz), 7.5-6.9 (m, 7 H), 5.06 (s, 2 H), 3.83 (s, 3 H)., 57830-14-5

The synthetic route of 57830-14-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; FIBROGEN, INC.; HO, Wen-Bin; ZHAO, Hongda; DENG, Shaojiang; NG, Danny; WRIGHT, Lee R.; WU, Min; ZHOU, Xiaoti; AREND, Michael P.; FLIPPIN, Lee A.; WO2013/134660; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.374706-07-7,1-(2,3-Dihydrobenzofuran-6-yl)ethanone,as a common compound, the synthetic route is as follows.

2-Bromo-l-(2,3-dihydro-benzofuran-6-yl)-ethanoneBr2 (0.36 ml, 7.01 mmol) was added dropwise to a stirring solution of l-(2,3-dihydro- benzofuran-6-yl)-ethanone (1.13 g, 6.97 mmol) in MeOH (20 mL) held at 00C. The reaction mixture was slowly allowed to reach room temperature. After 3 h, the reaction was quenched by the addition of NaHCO3 (aq, saturated)(until pH=8). Most of the methanol was removed under reduced pressure and the residue was extracted twice with EtOAc (2×20 mL). The organic extracts were pooled, washed with brine (10 mL), dried over MgSO4 and concentrated under reduced pressure. The residue was purified by preparative HPLC using a gradient of 40-70% MeCN in a 0.1M ammonium acetate buffer as eluent. The fractions containing the desired product were pooled and most of the MeCN was removed under EPO reduced pressure. The residue was extracted with EtOAc (2×20 mL) and the combined organic layers was washed with brine, dried over MgSO4 and concentrated. The obtained was finely washed MeOH to give the title compound.1H-NMR (CDC13, 400 MHz): delta 3.25 (t, 2H), 4.39 (s, 2H), 4.61 (t, 2H), 7.24-7.36 (m, 2H), 7.45-7.52 (m, IH).-, 374706-07-7

As the paragraph descriping shows that 374706-07-7 is playing an increasingly important role.

Reference：
Patent; ASTRAZENECA AB; WO2006/137796; (2006); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

23405-32-5, Methyl 1-oxo-1,3-dihydroisobenzofuran-5-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 2 was converted to 1,3-dihydro-1-oxoisobenzofuran-5-carbohydrazide (3) by reacting with hydrazine hydrate in methanol. To a mixture of methyl-1,3-dihydro-1-oxoisobenzofuran-5-carboxylate (2, 5.2 mmol) and methanol (5 mL) at 20-25 C, hydrazine hydrate (5 mL) was added. The reaction mass was refluxed for 4 h and the reaction completion was monitored by TLC. The reaction mass was filtered, washed with water followed by methanol and finally dried to get the pure product. White colour solid, yield: 98 %, m.p.: 220-230 C. IR (KBr, numax, cm-1): 3284 (-NH), 3178 (-NH2), 3053 (-CH), 1759 (lactone C=O), 1644 (amide C=O), 1045 (C-O); 1H NMR (400 MHz, DMSO-d6) delta ppm: 5.44 (2H, d, CH2), 7.41 (1H, m, ArH), 7.72 (1H, m, ArH), 8.01 (1H, dd, ArH), 9.81 (1H, s, CONH), 4.50 (2H, -NH2); 13C NMR (100 MHz, DMSO-d6) delta ppm: 170.2, 164.5, 144.8, 134.8, 128.7, 127.6, 126.4, 123.8, 60.6. LC-MS: m/z: 192 [M]+, 193 [M+1]+. Elemental analysis of C9H8N2O3 calcd. (found) %: C, 56.28 (56.23); H, 4.20 (4.20); N, 14.58 (14.58); O, 24.98 (24.99)., 23405-32-5

As the paragraph descriping shows that 23405-32-5 is playing an increasingly important role.

Reference：
Article; Rao, Nunna Madhava; Viveka, Tella Lakshmi; Raju, Koneti Mallikarjuna; Chary, Maringanti Thirumala; Asian Journal of Chemistry; vol. 32; 1; (2020); p. 95 – 100;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem