Category: benzofurans

Hashmi, A. Stephen K. published the artcileGold Catalysis: Anellated Heterocycles and Dependency of the Reaction Pathway on the Tether Length, Name: 2-Iodobenzofuran, the publication is Advanced Synthesis & Catalysis (2009), 351(17), 2855-2875, database is CAplus.

A series of furan-yne substrates with an arylalkynylamide substructure were prepared and subjected to catalytic amounts of phosphanegold(I) complexes. With two carbon atoms in the tether between the arylalkynylamide and the furan subunits, the formation of benzoanellated heterocycles was observed, and a number of interesting fused dihydroindole frameworks, e.g., I, could be accessed in this way. With three carbon atoms in the tether, the outcome was quite different, cyclopentadiene derivatives anellated to tetrahydropyridine rings, e.g., II, were isolated. The two different pathways suggested are supported by calculations regarding the selectivity-determining step.

Advanced Synthesis & Catalysis published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Name: 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Riviere, Celine published the artcileNew stilbene dimers against amyloid fibril formation, Safety of 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(11), 3441-3443, database is CAplus and MEDLINE.

Twenty stilbene derivatives and moracin M extracted from natural products were tested against amyloid-β peptide (Aβ) aggregation. Results of stilbene monomer derivatives indicated that interaction with resveratrol and piceid was specific. Concerning oligomers, scirpusin A and ε-viniferin glucoside demonstrated a strong inhibition of the aggregation process.

Bioorganic & Medicinal Chemistry Letters published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Safety of 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Li, Hong Xu published the artcileIdentification of anti-melanogenesis constituents from morus alba l. leaves, Formula: C14H10O4, the publication is Molecules (2018), 23(10), 1-11, database is CAplus and MEDLINE.

The individual parts of Morus alba L. including root bark, branches, leaves, and fruits are used as a cosmetic ingredient in many Asian countries. This study identified several anti-melanogenesis constituents in a 70% ethanol extract of M. alba leaves. The Et acetate fraction of the initial ethanol extract decreased the activity of tyrosinase, a key enzyme in the synthetic pathway of melanin. Twelve compounds were isolated from this fraction and their structures were identified based on spectroscopic spectra. Then, the authors investigated the anti-melanogenesis effects of the isolated compounds in B16-F10 mouse melanoma cells. Compounds 3 and 8 significantly inhibited not only melanin production but also intracellular tyrosinase activity in alpha-melanocyte-stimulating-hormone (a-MSH)-induced B16-F10 cells in a dose-dependent manner. These same compounds also inhibited melanogenesis-related protein expression such as microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related protein-1 (TRP-1). Compound 3 modulated the cAMP-responsive element-binding protein (CREB) and p38 signaling pathways in a-MSH-activated B16-F10 melanoma cells, which resulted in the anti-melanogenesis effects. These results suggest that compound 3, isolated from M. alba leaves, could be used to inhibit melanin production via the regulation of melanogenesis-related protein expression.

Molecules published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Formula: C14H10O4.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

He, Shuwen published the artcileFacile functionalization at the C2 position of a highly substituted benzofuran, Safety of 2-Iodobenzofuran, the publication is Tetrahedron Letters (2014), 55(14), 2212-2216, database is CAplus.

To expedite an SAR study on C(2) of a highly substituted benzofuran ring system, a method for the preparation of a key precursor, iodide I, was developed. From I, a diverse set of compounds with different substituents at C(2) were prepared efficiently by Suzuki reaction.

Tetrahedron Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Safety of 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Zhang, Fuyi published the artcileSynthesis of het(aryl) imidazole C-nucleoside analogues by CoFe₂O₄ NPs catalyzed muti-component coupling reaction, Application of 2-Iodobenzofuran, the publication is Carbohydrate Research (2019), 39-50, database is CAplus and MEDLINE.

A general synthesis of hetaryl and aryl C-4(5) linked imidazole C-nucleoside analogs has been developed by the reaction of sugar alkynes with het(aryl) iodides, KMnO₄/TBAB oxidation and CoFe₂O₄ NPs catalyzed multi-component coupling of the corresponding diketones, NH₄OAc and aromatic aldehydes in one-pot. The sugar alkynes include pyranosides and furanosides with acid sensitive protecting groups. The het(aryl) iodides comprise iodoaroms., iodoheterocycles, and sterically hindered iodoheteroaroms.

Carbohydrate Research published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C18H10, Application of 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Che, Minghui published the artcileHPLC method for determination of related substances in escitalopram oxalate citalopram tablets, Synthetic Route of 372941-54-3, the publication is Heilongjiang Yiyao (2015), 28(1), 65-69, database is CAplus.

Objective: To establish an HPLC method for determination of escitalopram oxalate citalopram on material test. Methods: The stationary phase was Agilent C₁₈ (150 mm × 4.5 mm, 5 μm); the mobile phase was (1.5 g, sodium acetate and 0.4 mL glacial acetic acid to dissolve 1 L water, adding 1 M NaOH to adjust pH 5.2 buffer) methanol and acetonitrile-buffer (33:7:60); the flow rate was 1.0 mL/min; the detection wavelength was 239 nm; and the sample quantity was 10 μL. Results: Under the chromatog. conditions, the principal components and the related materials were completely separated, and the separating degree of all impurities was in good condition. In 0.375-3 μg/mL, 0.621-4.91 μg/mL and 4.91-4.90 μg/mL, three main relevant materials had good linear relationship between peak area and concentration, and the average recovery conformed to specified requirements. Conclusion: This method is simple and reproducible and it can be used for quality control of escitalopram oxalate citalopram tablets.

Heilongjiang Yiyao published new progress about 372941-54-3. 372941-54-3 belongs to benzofurans, auxiliary class Other Aliphatic Heterocyclic,Fluoride,Nitrile,Amine,Benzene,Ester, name is 1-(3-(Dimethylamino)propyl)-1-(4-fluorophenyl)-3-oxo-1,3-dihydroisobenzofuran-5-carbonitrile, and the molecular formula is C20H19FN2O2, Synthetic Route of 372941-54-3.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Zheng, Jian published the artcile1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU)-Promoted Decomposition of Difluorocarbene and the Subsequent Trifluoromethylation, Name: 2-Iodobenzofuran, the publication is Organic Letters (2015), 17(3), 532-535, database is CAplus and MEDLINE.

Difluorocarbene derived from various carbene precursors could be effectively decomposed by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). This decomposition process was successfully applied in the subsequent trifluoromethylation of a variety of (hetero)aryl iodides without the addition of an external fluoride ion. Mechanistic investigation revealed the detailed difluorocarbene conversion process in which the decomposed difluorocarbene is finally transformed into a fluoride ion and carbon monoxide.

Organic Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C9H17NO, Name: 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Yang, Jing published the artcileQuantitative analysis of flavonoids in different medicinal parts of Morus alba, Formula: C14H10O4, the publication is Zhongguo Yaofang (2014), 25(27), 2550-2552, database is CAplus.

The aim is to determine contents of total flavonoids in leaves, fruit, branch and root bark of Morus alba. With moracin as substance control, the contents of total flavonoids in 95% ethanol extract, water extract after ethanol extraction from the leaves, fruit, branch and root bark of M.alba were measured by spectrophotometry. The linear range of moracin was 0.025-0.050mg/mL(r=0.9998). RSD of precision, stability and reproducibility tests were all lower than 1%. The mass fraction of total flavonoids in 95% ethanol extract from the leaves, fruit, branch and root bark of M. alba was 13.60%, 7.19%, 10.53% and 18.38%. The mass fraction of total flavonoids in water extract after ethanol extraction from the leaves, fruit, branch and root bark of M. alba was 0.26%, 0.60%, 0.40% and 0.01%. The content of total flavonoids in root bark of M. alba is the highest, ethanol extract of it is effective.

Zhongguo Yaofang published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C5H10O2S, Formula: C14H10O4.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Ko, Wonmin published the artcileKuwanon T and Sanggenon A Isolated from Morus alba Exert Anti-Inflammatory Effects by Regulating NF-κB and HO-1/Nrf2 Signaling Pathways in BV2 and RAW264.7 Cells, Application In Synthesis of 56317-21-6, the publication is Molecules (2021), 26(24), 7642, database is CAplus and MEDLINE.

We previously investigated the methanolic extract of Morus alba bark and characterized 11 compounds from the extract: kuwanon G (1), kuwanon E (2), kuwanon T (3), sanggenon A (4), sanggenon M (5), sanggenol A (6), mulberofuran B (7), mulberofuran G (8), moracin M (9), moracin O (10), and norartocarpanone (11). Herein, we investigated the anti-inflammatory effects of these compounds on microglial cells (BV2) and macrophages (RAW264.7). Among them, 3 and 4 markedly inhibited the lipopolysaccharide (LPS)-induced production of nitric oxide in these cells, suggesting the anti-inflammatory properties of these two compounds These compounds inhibited the production of prostaglandin E2, interleukin-6, and tumor necrosis factor-α, and the expression of inducible nitric oxide synthase and cyclooxygenase-2 following LPS stimulation. Pretreatment with 3 and 4 inhibited the activation of the nuclear factor kappa B signaling pathway in both cell types. The compounds also induced the expression of heme oxygenase (HO)-1 through the activation of nuclear factor erythroid 2-related factor 2. Suppressing the activity of HO-1 reversed the anti-inflammatory effects caused by pretreatment with 3 and 4, suggesting that the anti-inflammatory effects were regulated by HO-1. Taken together, 3 and 4 are potential candidates for developing therapeutic and preventive agents for inflammatory diseases.

Molecules published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Application In Synthesis of 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Nguyen, Thi Thanh Binh published the artcileSynthesis of (Z) isomers of benzoheterocyclic derivatives of combretastatin A-4: a comparative study of several methods, COA of Formula: C8H5IO, the publication is Tetrahedron (2013), 69(10), 2336-2347, database is CAplus.

Several methods for the preparation of (Z) trimethoxystyrene derivatives I [R = H, X = O, S, N-Boc, NH; R = OMe, NO₂, X = S] & II were investigated. After finding that the Wittig reaction led to unsatisfactory results, three different strategies were considered: a Suzuki coupling with a stereodefined monobromoalkene, a combination of hydrosilylation/vinylsilane hydrolysis and a palladium-catalyzed semi-hydrogenation step, using DMF/KOH as the hydrogen source. Our studies led us to prepare a series of diarylacetylene derivatives via a Sonogashira coupling reaction, and also to find out a copper-free basic cyclization leading to benzo[b]thiophenes. The final choice for the synthesis method of I & II strongly depends on the target compound but the semi-hydrogenation, which avoids the use of a toxic tin reducing agent, should be generally preferred.

Tetrahedron published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, COA of Formula: C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem