benzofurans | Page 117 of 684 | Heterocyclic Building Block-benzofuran

Ha, Manh Tuan’s team published research in Phytochemistry (Elsevier) in 155 | CAS: 56317-21-6

Phytochemistry (Elsevier) published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Category: benzofurans.

Ha, Manh Tuan published the artcileChalcone derivatives from the root bark of Morus alba L. act as inhibitors of PTP1B and α-glucosidase, Category: benzofurans, the publication is Phytochemistry (Elsevier) (2018), 114-125, database is CAplus and MEDLINE.

As part of our continuing research to obtain pharmacol. active compounds from Morus alba L. (Moraceae), four Diels-Alder type adducts (DAs) [morusalbins A-D], one isoprenylated flavonoid [albanin T], together with twenty-one known phenolic compounds were isolated from its root bark. The chem. structures were established using NMR, MS, and ECD spectra. The DAs including morusalbins A-D, albasin B, macrourin G, yunanensin A, mulberrofuran G and K, and albanol B exhibited strong inhibitory activities against both protein tyrosine phosphatase 1B (PTP1B) (IC₅₀, 1.90-9.67 μM) and α-glucosidase (IC₅₀, 2.29-5.91 μM). In the kinetic study, morusalbin D, albasin B, and macrourin G showed noncompetitive PTP1B inhibition, with K_i values of 0.33, 1.00, and 1.09 μM, resp. In contrast, these DAs together with yunanensin A produced competitive inhibition of α-glucosidase, with K_i values of 0.64, 0.42, 2.42, and 1.19 μM, resp. Furthermore, mol. docking studies revealed that these active DAs have high affinity and tight binding capacity towards the active site of PTP1B and α-glucosidase.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Ben-David, O.’s team published research in Chemistry of Materials in 9 | CAS: 596-01-0

Chemistry of Materials published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Category: benzofurans.

Ben-David, O. published the artcileSimple Absorption Optical Fiber pH Sensor Based on Doped Sol-Gel Cladding Material, Category: benzofurans, the publication is Chemistry of Materials (1997), 9(11), 2255-2257, database is CAplus.

The construction and the operation properties of an organically doped sol-gel cladded optical fiber pH sensor, is described. The SiO₂-entrapped indicator in the absorption-based device was α-naphtholphthalein, pumped with a continuous wave He-Ne 633 nm laser. The transmitted signal through the sensing fiber yields a response in the range pH = 4-11, where signal level doubled itself from base to acid. The dynamic range is high with a 100% change between these pH values, allowing pH determination in ∼0.2 pH units accuracy, better than the current status of analogous fluorescent based sensors. The high dynamic range apparently cannot be fully explained by simple evanescent field considerations. The design and setup are attractive because of the simplicity and very low cost. The probe is easily prepared under regular room conditions by simple decladding of the fiber and sol-gel recoating; the optical fiber probe is easily replaceable; the optical setup is trivial and involves inexpensive common parts, in particular the light source which can be a simple red diode laser.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Ma, Fang’s team published research in Biological & Pharmaceutical Bulletin in 39 | CAS: 56317-21-6

Biological & Pharmaceutical Bulletin published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Quality Control of 56317-21-6.

Ma, Fang published the artcileAnti-HSV activity of Kuwanon X from Mulberry leaves with genes expression inhibitory and HSV-1 induced NF-κB deactivated properties, Quality Control of 56317-21-6, the publication is Biological & Pharmaceutical Bulletin (2016), 39(10), 1667-1674, database is CAplus and MEDLINE.

Six stilbene derivatives isolated from Mulberry leaves including Kuwanon X, Mulberrofuran C, Mulberrofuran G, Moracin C, Moracin M 3′-O-b-glucopyranoside and Moracin M were found to have antiviral effects against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2) at different potencies except for Mulberrofuran G. Kuwanon X exhibited the greatest activity against HSV-1 15577 and clin. strains and HSV-2 strain 333 with IC50 values of 2.2, 1.5 and 2.5μg/mL, resp. Further study revealed that Kuwanon X did not inactivate cell-free HSV-1 particles, but inhibited cellular adsorption and penetration of HSV-1 viral particles. Following viral penetration, Kuwanon X reduced the expression of HSV-1 IE and L genes, and decreased the synthesis of HSV-1 DNA. Furthermore, it was demonstrated that Kuwanon X inhibited the HSV-1-induced nuclear factor (NF)-κB activation through blocking the nuclear translocation and DNA binding of NF-κB. These results suggest that Kuwanon X exerts anti-HSV activity through multiple modes and could be a potential candidate for the therapy of HSV infection.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Zhou, Siqi’s team published research in Food & Function in 11 | CAS: 56317-21-6

Food & Function published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C7H3Cl2F3O2S, Product Details of C14H10O4.

Zhou, Siqi published the artcileA chondroprotective effect of moracin on IL-1β-induced primary rat chondrocytes and an osteoarthritis rat model through Nrf2/HO-1 and NF-κB axes, Product Details of C14H10O4, the publication is Food & Function (2020), 11(9), 7935-7945, database is CAplus and MEDLINE.

Osteoarthritis (OA) is a common joint disease characterized by cartilage degeneration and inflammation. Although moracin is known to play a role in anti-inflammation and anti-oxidation in several inflammatory diseases, its anti-inflammatory effect on OA remains largely unknown. Therefore, in order to explore the role of moracin in OA, we investigated the anti-inflammatory effect of moracin on interleukin (IL)-β-induced rat chondrocytes in vitro and surgically induced OA rat models in vivo. Rat chondrocytes were pretreated using moracin (0, 5, 10, 15μmol L-1) and then stimulated with IL-β (10 ng ml-1). Results showed that moracin reduced the expression of IL-1β-induced nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α), IL-6, inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX)-2 in both rat chondrocytes and cell culture supernatants. Besides, IL-1β-induced degradation of aggrecan and collage II, and the high expression of matrix metalloproteinase-13 (MMP-13) and a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS)-5 were also reversed by moracin. Moreover, moracin inhibited the translocation of p65 from the cytoplasm to nucleus induced by IL-1β and activated the Nrf2/HO-1 signaling pathway in chondrocytes. In OA rat models, moracin prevented cartilage of rats from destruction. All these findings above indicated that moracin could be a potentially effective drug for treating OA.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Shahab, Uzma et al. published their research in IUBMB Life in 2018 | CAS: 524-12-9

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Application of 524-12-9

Impact of wedelolactone in the anti-glycation and anti-diabetic activity in experimental diabetic animals was written by Shahab, Uzma;Faisal, Mohammad;Alatar, Abdulrahman A.;Ahmad, Saheem. And the article was included in IUBMB Life in 2018.Application of 524-12-9 The following contents are mentioned in the article:

The glycation reaction is the addition of free carbonyl group of reducing sugar to the free amino groups of proteins, lipoproteins and nucleic acids which results in the formation of an Amadori product which may ultimately lead to the generation of advanced glycation products (AGEs). The impact of AGEs on proteins consequently generates free radicals, “a key player” for the pathogenesis of diabetes mellitus. Gel electrophoresis was carried out to see the visual changes taking place as a result of the glycation reaction. In this study, the anti-glycation and anti-diabetic effect of wedelolactone (WED) was seen both in vitro and in vivo. WED reverted various biochem. markers in streptozotocin-induced diabetic rats along-with the improvements in the oxidative stress markers. It also decreased the levels of the glycated serum protein and fasting blood glucose. Broadly, WED not only inhibited glycation in vitro but also proved to be an effective in vivo anti-glycating agent. © 2018 IUBMB Life, 2018 This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Application of 524-12-9).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Buzon, Beverlee et al. published their research in ACS Omega in 2021 | CAS: 524-12-9

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Formula: C16H10O7

Identification of Bioactive SNM1A Inhibitors was written by Buzon, Beverlee;Grainger, Ryan A.;Rzadki, Cameron;Huang, Simon York Ming;Junop, Murray. And the article was included in ACS Omega in 2021.Formula: C16H10O7 The following contents are mentioned in the article:

SNM1A is a nuclease required to repair DNA interstrand cross-links (ICLs) caused by some anticancer compounds, including cisplatin. Unlike other nucleases involved in ICL repair, SNM1A is not needed to restore other forms of DNA damage. As such, SNM1A is an attractive target for selectively increasing the efficacy of ICL-based chemotherapy. Using a fluorescence-based exonuclease assay, we screened a bioactive library of compounds for inhibition of SNM1A. Of the 52 compounds initially identified as hits, 22 compounds showed dose-response inhibition of SNM1A. An orthogonal gel-based assay further confirmed nine small mols. as SNM1A nuclease activity inhibitors with IC₅₀ values in the mid-nanomolar to low micromolar range. Finally, three compounds showed no toxicity at concentrations able to significantly potentiate the cytotoxicity of cisplatin. These compounds represent potential leads for further optimization to sensitize cells toward chemotherapeutic agents inducing ICL damage. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Formula: C16H10O7).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Munjal, Kavita et al. published their research in World Journal of Pharmacy and Pharmaceutical Sciences in 2020 | CAS: 524-12-9

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Synthetic Route of C16H10O7

Development of validated HPTLC method for quantification of luteolin in Eclipta alba and its formulation was written by Munjal, Kavita;Uniyal, Rashmi;Kumar, Ashok;Arora, Anchal;Gupta, Apeksha;Haye, Abdul;Gauttam, Vinod Kumar. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2020.Synthetic Route of C16H10O7 The following contents are mentioned in the article:

A simple, sensitive, precise, robust and rapid high performance thin layer chromatog. (HPTLC) method for anal. of luteolin in Eclipta alba extract as well as in the formulation was developed and validated. The mobile phase system consisted of toluene- Et acetate- formic acid (5: 3.5: 0.1, volume/volume/v). Densitometry anal. was carried out in the absorbance/reflectance mode at the wavelength of 350 nm at room temperature (25 ± 2°C). The system was found to give compact bands for luteolin (Rf value of 0.34±0.02). The linear regression anal. data for the calibration plots showed good linearity (r² = 0.99601 ± 0.002) in the concentration range 200-1200 ng spot^-1. The method was validated according to the International Conference on Harmonization (ICH) guidelines. The limits of detection and quantitation were 20 and 60 ng spot^-1, resp. The method has been successfully applied in the anal. of herbal extract and market formulations containing luteolin. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Synthetic Route of C16H10O7).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Fang, Yi et al. published their research in Journal of Electroanalytical Chemistry in 2019 | CAS: 524-12-9

Electrochemical characterization of aromatic corrosion inhibitors from plant extracts was written by Fang, Yi;Suganthan, Baviththira;Ramasamy, Ramaraja P.. And the article was included in Journal of Electroanalytical Chemistry in 2019.Electric Literature of C16H10O7 The following contents are mentioned in the article:

Plant extracts were regarded as green alternatives as inhibitors for metal corrosion prevention and mitigation. Therefore, understanding the electrochem. properties and the reaction mechanisms of the electro-active compounds from the plant extracts is necessary to further explore the mechanism and application of the plant extract-based additives for corrosion prevention and mitigation. Among different plant derived chems., aromatic compounds are among the most effective for corrosion inhibition and mitigation. Thus, the electrochem. properties of seven aromatic active compounds from the plant extracts – caffeic acid, thymol (2-isopropyl-5-methylphenol, IPMP), gallic acid (3,4,5-trihydroxybenzoic acid), tannic acid, lawsone (2-hydroxy-1,4-naphthoquinone), wedelolactone, and ellagic acid were studied using multiwalled C nanotube modified glassy-C electrode, and reported to enhance the fundamental understanding of their redox behavior at different environmental pH conditions. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Electric Literature of C16H10O7).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Gharat, Neha N. et al. published their research in Preparative Biochemistry & Biotechnology in 2020 | CAS: 524-12-9

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Application of 524-12-9

Response surface methodology for the extraction of wedelolactone from Eclipta alba using aqueous two-phase extraction was written by Gharat, Neha N.;Rathod, Virendra K.. And the article was included in Preparative Biochemistry & Biotechnology in 2020.Application of 524-12-9 The following contents are mentioned in the article:

Aqueous two-phase extraction of wedelolactone from Eclipta alba was studied using the polymer-salt system. The system consisted of polyethylene glycol (PEG) as a top phase (polymer) and sodium citrate as a bottom phase (salt). Process parameters such as PEG concentration, PEG mol. weight, salt concentration, and pH have been optimized using response surface methodol. (RSM) with the help of central composite design (CCD). The optimized conditions for aqueous two-phase system (ATPS), in the case of one factor at a time approach, were found as PEG 6000, PEG concentration 18% (w/v), salt concentration 16% (w/v), and pH 7; with maximum extraction yield of 6.52 mg/g. While, RSM studies showed maximum extraction yield of 6.73 mg/g with the optimized parameters as PEG 6000, PEG concentration 18% (w/v), salt concentration 17.96% (w/v), and pH 7. ATPS was found to give a 1.3 fold increase in the extraction yield of wedelolactone as compared to other conventional extraction methods. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Application of 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Application of 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Li, Yuchen et al. published their research in Angewandte Chemie, International Edition in 2022 | CAS: 524-12-9

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.HPLC of Formula: 524-12-9

Momomycin, an Antiproliferative Cryptic Metabolite from the Oxytetracycline Producer Streptomyces rimosus was written by Li, Yuchen;Lee, Seoung Rak;Han, Esther J.;Seyedsayamdost, Mohammad R.. And the article was included in Angewandte Chemie, International Edition in 2022.HPLC of Formula: 524-12-9 The following contents are mentioned in the article:

Natural products provide an important source of pharmaceuticals and chem. tools. Traditionally, assessment of unexplored microbial phyla has led to new natural products. However, with every new microbe, the number of orphan biosynthetic gene clusters (BGC) grows. As such, the more difficult proposition is finding new mols. from well-studied strains. Herein, we targeted Streptomyces rimosus, the widely-used oxytetracycline producer, for the discovery of new natural products. Using MALDI-MS-guided high-throughput elicitor screening (HiTES), we mapped the global secondary metabolome of S. rimosus and structurally characterized products of three cryptic BGCs, including momomycin, an unusual cyclic peptide natural product with backbone modifications and several non-canonical amino acids. We elucidated important aspects of its biosynthesis and evaluated its bioactivity. Our studies showcase HiTES as an effective approach for unearthing new chem. matter from “drained” strains. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9HPLC of Formula: 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.HPLC of Formula: 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem