Category: benzofurans

Robien, Wolfgang published the artcileThe advantage of automatic peer-reviewing of 13C-NMR reference data using the CSEARCH-protocol, Name: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Molecules (2021), 26(11), 3413, database is CAplus and MEDLINE.

A systematic investigation of the exptl. 13C-NMR spectra published in Mols. during the period of 1996 to 2015 with respect to their quality using CSEARCH-technol. is described. It is shown that the systematic application of the CSEARCH-Robot-Referee during the peer-reviewing process prohibits at least the most trivial assignment errors and wrong structure proposals. In many cases, the correction of the assignments/chem. shift values is possible by manual inspection of the published tables; in certain cases, reprocessing of the original exptl. data might help to clarify the situation, showing the urgent need for a public domain repository. A comparison of the significant key numbers derived for Mols. against those of other important journals in the field of natural product chem. shows a quite similar level of quality for all publishers responsible for the six journals under investigation. From the results of this study, general rules for data handling, data storage, and manuscript preparation can be derived, helping to increase the quality of published NMR-data and making these data available as validated reference material.

Molecules published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Name: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Rohatgi, H. L. published the artcileOrganomercury derivatives as antiseptics. II. Symmetrical phthaleins and fluoresceins, Recommanded Product: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Indian Journal of Applied Chemistry (1958), 117-20, database is CAplus.

Several sym. phthaleins and fluoresceins, their Hg and Br derivatives, were prepared and tested for bactericidal activity. Phthalic anhydride was treated with phenols to give the following compounds (phenol, % yield, dye formula, m.p. given): m-cresol, 54, C₂₂H₁₆O₃, 215°; p-cresol, 54, C₂₂H₁₆O₃, 246°; pyrocatechol, 54, C₂₀H₁₂O₅, 200°; hydroquinone, 51, C₂₀H₁₂O₅, 226°; pyrogallol, 71, C₂₀H₁₂O₇, 285°; phloroglucinol, 57, C₂₀H₁₂O₇, 250°; 1-naphthol, 49, C₂₈H₁₈O₄, 234-5°; and 2-naphthol, 50, C₂₈H₁₆O₃, 293°. The dyes were mercurated by the method of White (C.A. 15, 536) and the Hg substituents replaced by Br to give the following derivatives (dye, formula of Hg derivative, color of Hg derivative, color of Br derivative, m.p. of Br derivative given): phenolphthalein, C₂₀H₁₁O₄(HgOAc)₂(HgOH)₂, light pink, light red, >300°; ο-cresolphthalein, C₂₂H₁₆O₄(HgOAc)₂, green, orange, 255°; 3,6-dimethylfluoran, C₂₂H₁₄O₃(HgOAc)₂, brown, orange, 249-50°; 2,7-dimethylfluoran, C₂₂H₁₄O₃(HgOAc)₂, brown, orange, 984-5°; 4,5-dihydroxyfluoran, C₂₀H₁₀O₅(HgOH)₂, green, dirty orange, 285°; 3,6-dihydroxyfluoran, C₂₀H₈O₅(HgOAc)₄ red, orange-red, >300°; 2,7-dihydroxyfluoran, C₂₀H₁₀O₅(HgOH)₂, brown, dirty orange, 200° (decomposition); 4,5-dihydroxyfluorescein, C₂₀H₁₀O₇(HgOAc)₂, deep red, red, >300°; 1,8-dihydroxyfluorescein, C₂₀H₈O₇(HgOAc)₄, dirty red, red, >300°; α-naphthophthalein, C₂₈H₁₇O₄HgOAc, black, brown, >300°; and β-naphthophthalein, C₂₈H₁₅O₃HgOAc, black-brown, >300°. The mercurated compounds were more active against Staphylococcus aureus and Escherichia coli than the dyes but not more active than mercurochrome.

Indian Journal of Applied Chemistry published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Recommanded Product: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Rozman, Martin published the artcileMulticolor Transparent-Conductive-Electrode Free Electronic Paper based on Steel Foil and Water Electrolyte with pH Indicator Dyes, Product Details of C28H18O4, the publication is Advanced Electronic Materials (2022), 8(4), 2100901, database is CAplus.

Electronic paper devices, also known as electrochromic devices, are known for their ability to change color and remain in a particular color state even after the elec. power is turned off. Traditional devices such as electrochromic windows use mechanisms such as electrophoresis or intercalation and use special materials such as anhydrous electrolytes and transparent conductive materials (TCMs). As a result, these devices can sometimes be relatively difficult to assemble, especially in developing countries where such materials are difficult to obtain. Recently, some improvements are made by using alternative electrode positioning that do not require TCM. Here, a novel multicolor display module that is recyclable, can be fabricated from readily available materials, and can be scaled according to the desired screen size is presented. The presented device is a semi-open electrochem. device that uses pH indicator dyes and an aqueous electrolyte solution in combination with readily available stainless steel sheet.

Advanced Electronic Materials published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Product Details of C28H18O4.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Thiel, A. published the artcileBicolored phthaleins, Application of 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Z. physik. Chem. (1931), 352-6, database is CAplus.

The phthaleins of the series homologous to phenolphthalein have been assumed to show but one color change. α-Naphtholphthalein on very careful purification lost its pink to brownish color and was obtained colorless. In alc. the color changes are from colorless to orange-yellow and then by way of green to blue. This is difficult to observe in water because of the limited solubility of the free phthalein. p-Xylenolphthalein and thymolphthalein show similar color changes including the colorless stage in alc. The 1st change is from the colorless phthalein to that of the primary quinoid anions, and the 2nd change is from this color to the deep color of the secondary meriquinoid anions.

Z. physik. Chem. published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C11H21BF4N2O2, Application of 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Zha, Gao-Feng published the artcilePalladium-Catalyzed Fluorosulfonylvinylation of Organic Iodides, Product Details of C8H5IO, the publication is Angewandte Chemie, International Edition (2017), 56(17), 4849-4852, database is CAplus and MEDLINE.

In the presence of Pd(OAc)₂, ethenesulfonyl fluoride underwent chemo-, regio- and diastereoselective aerobic Heck reactions with aryl, heteroaryl, and vinyl iodides mediated by silver trifluoroacetate in acetone to yield arylvinylsulfonyl fluorides such as (E)-PhCH:CHSO₂F and (E,E)-PhCH:CHCH:CHSO₂F in 24-99% yields. The structure of (E,E)-PhCH:CHCH:CHSO₂F was determined by x-ray crystallog.

Angewandte Chemie, International Edition published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C11H22N2O4, Product Details of C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Cao, Yan-gang published the artcileTwo new phenolic constituents from the root bark of Morus alba L. and their cardioprotective activity, Related Products of benzofurans, the publication is Natural Product Research (2018), 32(4), 391-398, database is CAplus and MEDLINE.

A new biphenyl-furocoumarin, named morescoumarin A, and a new prenylated flavanone, named morflavanone A were isolated from the root bark of Morus alba L., together with four known compounds Their structures were determined by extensive spectroscopic analyses and comparison with literature data. The cardioprotective effects of these compounds against doxorubicin-induced cell death were evaluated by MTT method.

Natural Product Research published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Related Products of benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Hu, Qiu-Fen published the artcileAntiviral Phenolic Compounds from Arundina graminifolia, Formula: C14H10O4, the publication is Journal of Natural Products (2013), 76(2), 292-296, database is CAplus and MEDLINE.

Five new phenolic compounds, gramniphenols C-G (I–V), and eight known compounds (6-13) were isolated from the whole plant of Arundina graminifolia. Compounds 1, 4, and 5 showed anti-tobacco mosaic virus activity, with IC₅₀ values of 20.8, 40.8, and 57.7 μM, resp. Compounds 1-10 were also tested for their anti-HIV-1 activity; compounds 2, 3, and 6 displayed anti-HIV-1 activity with therapeutic index values above 100:1.

Journal of Natural Products published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Formula: C14H10O4.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Zhong, Zhuoheng published the artcileMolecular characterization of a geranyl diphosphate-specific prenyltransferase catalyzing stilbenoid prenylation from Morus alba, Application In Synthesis of 56317-21-6, the publication is Plant and Cell Physiology (2018), 59(11), 2214-2227, database is CAplus and MEDLINE.

Pharmaceutically active compounds from medical plants are attractive as a major source for new drug development. Prenylated stilbenoids with increased lipophilicity are valuable secondary metabolites which possess a wide range of biol. activities. So far, many prenylated stilbenoids have been isolated from Morus alba but the enzyme responsible for the crucial prenyl modification remains unknown. In the present study, a stilbenoid-specific prenyltransferase (PT), termed Morus alba oxyresveratrol geranyltransferase (MaOGT), was identified and functionally characterized in vitro. MaOGT recognized oxyresveratrol and geranyl diphosphate (GPP) as natural substrates, and catalyzed oxyresveratrol prenylation. Our results indicated that MaOGT shared common features with other aromatic PTs, e.g. multiple transmembrane regions, conserved functional domains and targeting to plant plastids. This distinct PT represents the first stilbenoid-specific PT accepting GPP as a natural prenyl donor, and could help identify addnl. functionally varied PTs in moraceous plants. Furthermore, MaOGT might be applied for high-efficiency and large-scale prenylation of oxyresveratrol to produce bioactive compounds for potential therapeutic applications.

Plant and Cell Physiology published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C19H14O2, Application In Synthesis of 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Guo, Fang published the artcileMoracin M inhibits lipopolysaccharide-induced inflammatory responses in nucleus pulposus cells via regulating PI3K/Akt/mTOR phosphorylation, COA of Formula: C14H10O4, the publication is International Immunopharmacology (2018), 80-86, database is CAplus and MEDLINE.

Moracin M, a phenolic component obtained from Mori Cortex, has been reported to have anti-inflammatory activities. The present study was designed to investigate the effects and mechanisms of Moracin M on lipopolysaccharide (LPS)-treated nucleus pulposus cells (NPCs) in intervertebral disk. NPCs were treated with moracin M at different concentrations for 1 h and then stimulated with LPS (0.5μg/mL) for 24 h. The result demonstrated that moracin M could significantly inhibit LPS-induced inflammation. The elevated levels of IL-1β, TNF-α and IL-6 induced by LPS could be reversed by moracin M in NPCs. Moreover, moracin M increased the expressions of autophagy-related proteins and up-regulated the phosphorylation of PI3K/Akt/mTOR in LPS-treated NPCs. In conclusion, our data demonstrated that moracin M might inhibit LPS-induced PI3K and Akt phosphorylation, which leading to promote the autophagy and inhibit the inflammatory mediator production in NPCs.

International Immunopharmacology published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, COA of Formula: C14H10O4.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Arbatsky, I. W. published the artcileTitration theory of dilute solutions, Name: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Zeitschrift fuer Analytische Chemie (1938), 117-26, database is CAplus.

The theory of titrating dilute solutions is discussed with respect to the magnitude of the error and the determination of the proper correction values. The titration of carbonates with phenolphthalein and α-naphtholphthalein as indicators is discussed in detail and the formulas for determining the correction factor are worked out. The advantages of the latter indicator are pointed out with respect to this titration.

Zeitschrift fuer Analytische Chemie published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Name: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem