Category: 87-41-2

An article Investigation of the Potential Environmental Risks of Phthalate Derivatives Designed To Be Environmentally Friendly WOS:000528480300001 published article about ACID ESTERS; DEGRADATION; PHOTOLYSIS; TOXICITY; WATER; DERIVATIZATION; ORGANIZATION; METABOLITES; DIESTERS; PATTERNS in [Zhang, Wenhui; Sun, Ruihao; Hou, Yilin; Li, Yu] North China Elect Power Univ, Coll Environm Sci & Engn, Beijing, Peoples R China; [Zhang, Wenhui; Sun, Ruihao; Hou, Yilin; Li, Yu] North China Elect Power Univ, State Key Lab Reg Optimizat Energy Syst, Beijing, Peoples R China; [Qiu, Youli] North China Inst Sci & Technol, Dept Environm Engn, Beijing, Peoples R China in 2020, Cited 57. SDS of cas: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Phthalate derivatives with low estrogenic activity, high infrared spectrum signals, high Raman characteristic vibration spectrum, high fluorescence intensity, and high ultraviolet sensitivity were selected as precursors from our previous studies, so that the changes in their toxicity and estrogenic activity during biological metabolism, ozone oxidation, photocatalytic degradation, photodegradation, and microbial degradation could be studied.The transformation pathways of these derivatives were simulated, and the reaction energy barriers were calculated. To determine the potential environmental risks of these phthalate derivatives, the pharmacophore models of biotoxicity and estrogen activity of phthalates were used to predict the biotoxicity and estrogen activity of the transformed products. The results showed an increase in the biotoxicity and estrogen activity of the biometabolites, ozonation products, photocatalytic degradation products, and microbial degradation products; the only products that did not follow this trend were the photodegradation products. Notably, the pathways that produced more potentially toxic compounds were the less favorable paths. Our results indicate that the transformation products of the designed environmentally friendly phthalate derivatives potentially pose environmental risks. To avoid such risks, the environmental transformation pathway of these derivatives should be simulated to screen for environmentally friendly phthalate molecules. Environ Toxicol Chem 2020;00:1-11. (c) 2020 SETAC

Welcome to talk about 87-41-2, If you have any questions, you can contact Zhang, WH; Sun, RH; Hou, YL; Qiu, YL; Li, Y or send Email.. SDS of cas: 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Safety of Isobenzofuran-1(3H)-one. Xin, MH; Sun, JJ; Huang, W; Tang, F; Liu, ZY; Jin, Q; Wang, J in [Xin, Minhang; Sun, Jiajia] Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Pharm, Dept Med Chem, 76 Yanta West Rd, Xian 710061, Peoples R China; [Huang, Wei] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China; [Tang, Feng; Liu, Zhaoyu; Jin, Qiu; Wang, Jia] Jiangsu Simcere Pharmaceut Co Ltd, 699-18 Xuan Wu Dist, Nanjing 210042, Peoples R China published Design and synthesis of novel phthalazinone derivatives as potent poly(ADP-ribose)polymerase 1 inhibitors in 2020, Cited 22. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Aim:The development of effective PARP-1 inhibitors has received great enthusiasm in medicinal chemistry communities.Results:A new series of novel phthalazinone derivatives were designed and synthesized. Among these,B1andB16displayed more potent PARP-1 inhibitory activities than olaparib.B16gave an IC(50)value of 7.8 nM against PARP-1, and a PF(50)value of 3.4 in the sensitizing effect assay. Thein vivopharmacokinetic properties evaluation showedB16displayed insufficient oral exposure, and it was also not stable in rat blood.Conclusion:The results indicated that our design phthalazinone derivatives were potent PARP-1 inhibitors, and compoundB16was a valuable lead compound with siginificantin vitroefficacy, deseaving further optimization so as to develop anticancer drug candidate.

Welcome to talk about 87-41-2, If you have any questions, you can contact Xin, MH; Sun, JJ; Huang, W; Tang, F; Liu, ZY; Jin, Q; Wang, J or send Email.. Safety of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

COA of Formula: C8H6O2. Recently I am researching about TRADITIONAL CHINESE MEDICINE; CORONARY-HEART-DISEASE; UP-REGULATION; ATHEROGENESIS; CHOLESTEROL; ACTIVATION; MACROPHAGE, Saw an article supported by the National Key Research and Development Program of China [2018YFC1704800, 2018YFC1704805, 2018YFC1704500, 2018YFC1704505]; Fundamental Research Funds for the Central Universities, Nankai University [63191723]. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Lei, W; Deng, YF; Hu, XY; Ni, JN; Jiang, M; Bai, G. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Atherosclerosis is initiated by the local inflammation response to lipid deposition, and the most commonly administered antiatherogenic drugs are statins. Based on traditional Chinese medicine (TCM) evidence, we aimed to find effective therapeutic agents other than statins. A TCM, Suxiao Jiuxin Pill (SX), has been widely used in curing cardiovascular diseases for thirty years. In this paper, a combination of pharmacologic studies and RNA-Seq transcriptomics were employed to explore the pharmacodynamic advantages of SX over atorvastatin in the ApoE(-/-) mouse. 113 differentially expressed genes that were modulated by SX to a greater degree than atorvastatin were primarily involved in immunomodulation. The expression of BTK, AKT1, c-jun and CD137 was effectively regulated by SX with better effect than atorvastatin. Then a dual-luciferase reporter assay for NF-kappa B inhibition was applied to identify active components in SX. As a result, Senkyunolide A (Sen A) and Ligustilide (Lig), the key immunomodulatory ingredients in SX, were found to inhibit the expression of CD137 which is a diagnostic biomarker in atherosclerosis. It was further confirmed that Lig effectively suppressed the expression of AP-1 and NF-kappa B and the phosphorylation of AKT. Therefore, Lig achieved its CD137 inhibition through suppressing the expression of AP-1 and AKT/NF-kappa B signaling pathway, which partly explains the immunomodulation of SX in atherosclerosis. Above all, phthalides may be the primary components of SX improving immune and inflammation response in atherosclerosis.

COA of Formula: C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Lei, W; Deng, YF; Hu, XY; Ni, JN; Jiang, M; Bai, G or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Pd-Catalyzed Dehydrogenative Oxidation of Alcohols to Functionalized Molecules WOS:000481979500029 published article about OXIDANT-FREE OXIDATION; CARBOXYLIC-ACID SALTS; ASTERISK-IR COMPLEX; SECONDARY ALCOHOLS; HOMOGENEOUS RUTHENIUM; HYDROGEN-PRODUCTION; N-ALKYLATION; ACCEPTORLESS; PALLADIUM; LIGAND in [Mori, Takamichi] Sanyo Onoda City Univ, Fac Engn, Dept Appl Chem, 1-1-1 Daigakudori, Yamaguchi 7560884, Japan; [Ishii, Chihiro; Kimura, Masanari] Nagasaki Univ, Grad Sch Engn, 1-14 Bunkyo Machi, Nagasaki 8528521, Japan in 2019, Cited 63. SDS of cas: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

A dehydrogenative oxidation reaction of primary alcohols to aldehydes catalyzed by a simple Pd/Xantphos catalytic system was developed under an argon or nitrogen atmosphere without oxidizing agents or hydrogen acceptors. The reaction product could be easily changed: under aerobic conditions, esters were obtained in aprotic solvents, whereas the corresponding carboxylic acids were produced in aqueous media. These oxidizing processes were applicable to the efficient synthesis of useful nitrogen-containing heterocyclic compounds such as indole, quinazoline, and benzimidazole via intramolecular versions of this reaction from amino alcohols.

Welcome to talk about 87-41-2, If you have any questions, you can contact Mori, T; Ishii, C; Kimura, M or send Email.. SDS of cas: 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Product Details of 87-41-2. In 2020 CHEMSUSCHEM published article about DIBAL-H REDUCTION; CATALYTIC-HYDROGENATION; CARBONYL REDUCTIONS; CHEMISTRY; GREEN; EFFICIENT; CINACALCET; TOOLS in [Oetvoes, Sandor B.; Kappe, C. Oliver] Karl Franzens Univ Graz, Inst Chem, NAWI Graz, Heinrichstr 28, A-8010 Graz, Austria; [Kappe, C. Oliver] RCPE, Ctr Continuous Synth & Proc CCFLOW, Inffeldgasse 13, A-8010 Graz, Austria in 2020, Cited 63. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Reductions of amides and esters are of critical importance in synthetic chemistry, and there are numerous protocols for executing these transformations employing traditional batch conditions. Notably, strategies based on flow chemistry, especially for amide reductions, are much less explored. Herein, a simple process was developed in which neat borane dimethylsulfide complex (BH3 center dot DMS) was used to reduce various esters and amides under continuous-flow conditions. Taking advantage of the solvent-free nature of the commercially available borane reagent, high substrate concentrations were realized, allowing outstanding productivity and a significant reduction in E-factors. In addition, with carefully optimized short residence times, the corresponding alcohols and amines were obtained in high selectivity and high yields. The synthetic utility of the inexpensive and easily implemented flow protocol was further corroborated by multigram-scale syntheses of pharmaceutically relevant products. Owing to its beneficial features, including low solvent and reducing agent consumption, high selectivity, simplicity, and inherent scalability, the present process demonstrates fewer environmental concerns than most typical batch reductions using metal hydrides as reducing agents.

Welcome to talk about 87-41-2, If you have any questions, you can contact Otvos, SB; Kappe, CO or send Email.. Product Details of 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Thermostimulated luminescence of poly(diphenylenephthalide) films. Kinetics and mechanistic steps of irradiative processes WOS:000501355900027 published article about BASIS-SET; PHTHALIDE); POLYMERS; THERMOLUMINESCENCE; MODEL; ELECTROLUMINESCENCE in [Ovchinnikov, Mikhail Yu; Antipin, Vyacheslav A.; Khursan, Sergey L.] Ufa Inst Chem UFRC RAS, 71 Prospect Oktyabrya, Ufa 450054, Russia in 2020, Cited 59. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Application In Synthesis of Isobenzofuran-1(3H)-one

Kinetics of thermostimulated luminescence (TSL) of poly(diphenylenephthalide) (PDPh) films has been studied using mathematical modelling and DFT approximation. TSL of PDPh-film was considered to be arising from irradiative deactivation of diphenylene (DP) fragment of polymer chain in excited state formed upon recombination of the spatial separated ion-radical pairs generated by photoexcitation. Two parallel monomolecular transformations leading to excited DP have been revealed: the first path is characterized by the activation parameters of the kinetic rate constant k1 which equal to Al ti 105 sec 1 and Eat ti 70 kJ mol(-1). This path may be interpreted in terms of mechanical relaxation theory by segmental polymer mobility as electron transfer (ET) from phthalide (Ph) anion-to DP cation-radical. The second channel is supposed to be consist of two consecutive ET from triarylmethyl anion-radical to phthalide neutral (A2 ti 1 sec 1, Ea2 ti 20 kJ mol(-1)), and then to DP cation-radical (A3 N 104 sec 1, E,3 N 40 kJ mol(-1)) of the polymer chain indicating y- and fl-relaxation, respectively. The revealed mechanistic steps and electron retention efficiency estimated in B97-2/6-311 + G(d,p) approximation for the most probable anion-radicals may point out the key role of domino quantum tunneling in transfer and recombination of charges in PDPh films.

Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recommanded Product: 87-41-2. I found the field of Chemistry very interesting. Saw the article Efficient catalytic oxidation of methyl aromatic hydrocarbon with N-alkyl pyridinium salts published in 2019, Reprint Addresses Chen, C (corresponding author), Ningbo Univ, Sch Mat Sci & Chem Engn, 818 Fenghua Rd, Ningbo 315211, Peoples R China.; Zhang, Z (corresponding author), China Tobacco Henan Ind Co Ltd, 8 3rd Ave, Zhengzhou 450001, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.

A series of N-alkyl pyridinium salts were synthesized and employed as metal-free catalyst for the selective oxidation of methyl aromatic hydrocarbon with molecular oxygen. The electronic effect of the substitutes was found to be an important factor for the catalytic performance. With the introduction of electron-donating substitute -N(CH3)(2), the conversion of p-xylene and selectivity of p-toluic acid could be simultaneously increased. 1-Benzyl-4-N,N-dimethylaminopyridinium salt showed the highest catalytic activity, and 95% conversion with 84% of selectivity to p-toluic acid could be obtained for the selective oxidation of p-xylene. Several methyl aromatic hydrocarbons could all be efficiently oxidized with the reported catalyst at the absence of any metal species.

Recommanded Product: 87-41-2. Welcome to talk about 87-41-2, If you have any questions, you can contact Zhang, QH; He, HH; Wang, HB; Zhang, Z; Chen, C or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Breaking C-O Bonds with Uranium: Uranyl Complexes as Selective Catalysts in the Hydrosilylation of Aldehydes WOS:000489204000019 published article about RING-OPENING POLYMERIZATION; METAL-FREE; CRYSTAL-STRUCTURE; REDUCTIVE DEPOLYMERIZATION; CARBONYL-COMPOUNDS; ALDOL CONDENSATION; SYMMETRIC ETHERS; CARBOXYLIC-ACIDS; CYCLOTRIMERIZATION; ETHERIFICATION in [Monsigny, Louis; Thuery, Pierre; Berthet, Jean-Claude; Cantat, Thibault] Univ Paris Saclay, CEA Saclay, CNRS, NIMBE,CEA, F-91191 Gif Sur Yvette, France in 2019, Cited 76. Formula: C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

We report herein the possibility to perform the hydrosilylation of carbonyls using actinide complexes as catalysts. While complexes of the uranyl ion [UO2](2+) have been poorly considered in catalysis, we show the potentialities of the Lewis acid [UO2(OTf)(2)] (1) in the catalytic hydrosilylation of a series of aldehydes. [UO2(OTf)(2)] proved to be a very active catalyst affording distinct reduction products depending on the nature of the reductant. With Et3SiH, a number of aliphatic and aromatic aldehydes are reduced into symmetric ethers, while (Pr3SiH)-Pr-i yielded silylated alcohols. Studies of the reaction mechanism led to the isolation of aldehyde/uranyl complexes, [UO2(OTf)(2)(4-Me2N-PhCHO)(3)], [UO2(mu-kappa(2)-OTf)(2)(PhCHO)](n), and [UO2(mu-kappa(2)-OTf(kappa(1)-OTf)(PhCHO)(2)](2), which have been fully characterized by NMR, IR, and single-crystal X-ray diffraction.

Formula: C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Monsigny, L; Thuery, P; Berthet, JC; Cantat, T or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Product Details of 87-41-2. Authors Rumyantsev, AV; Pichugov, AV; Bushkov, NS; Aleshin, DY; Strelkova, TV; Lependina, OL; Zhizhko, PA; Zarubin, DN in ROYAL SOC CHEMISTRY published article about in [Rumyantsev, Andrey, V; Pichugov, Andrey, V; Bushkov, Nikolai S.; Aleshin, Dmitry Yu; Strelkova, Tatyana, V; Lependina, Olga L.; Zhizhko, Pavel A.; Zarubin, Dmitry N.] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, Vavilov Str 28, Moscow 119991, Russia; [Rumyantsev, Andrey, V; Bushkov, Nikolai S.] Moscow MV Lomonosov State Univ, Dept Chem, Vorobevy Gory 1, Moscow 119991, Russia; [Pichugov, Andrey, V; Aleshin, Dmitry Yu] D Mendeleev Univ Chem Technol Russia, Higher Chem Coll, Miusskaya Sq 9, Moscow 125047, Russia in 2021, Cited 33. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

We report the first examples of direct imidation of lactones giving the corresponding cyclic imidates via oxo/imido heterometathesis with N-sulfinylamines catalysed by a well-defined silica-supported Ti imido complex.

Product Details of 87-41-2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recommanded Product: Isobenzofuran-1(3H)-one. I found the field of Polymer Science very interesting. Saw the article Synthesis of Poly(Arylene Alkenylene)s by Pd-Catalyzed Three-Component Coupling Polycondensation of Diiodoarenes, Non-Conjugated Dienes, and Nucleophiles that Involves Chain Walking Isomerization published in , Reprint Addresses Takeuchi, D (corresponding author), Tokyo Inst Technol, Lab Chem & Life Sci, R1-03,4259 Nagatsuta, Yokohama, Kanagawa 2268503, Japan.; Takeuchi, D (corresponding author), Hirosaki Univ, Grad Sch Sci & Technol, Dept Frontier Mat Chem, 3 Bunkyo Cho, Hirosaki, Aomori 0368561, Japan.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.

The Pd-catalyzed three-component coupling polycondensation of diiodoarenes, nonconjugated dienes, and carbonucleophiles afforded poly(arylene alkenylene)s with moderate molecular weight in good yield. The reaction involves Mizoroki-Heck coupling, olefin migration via chain walking, and addition of the carbonucleophile to the resulting pi-allylpalladium species. The polymerization with a slight excess of nucleophile with respect to diiodoarene also proceeded to give the polymer without significant decrease in molecular weight in spite of the nonstoichiometric mixture of the monomers. The Pd-catalyzed three-component coupling polycondensation of diiodoarenes, nonconjugated dienes, and diimide also proceeded. The base used in the reaction is critical for yield and molecular weight of the product. The reaction using NaHCO3 afforded the product with low solubility, which can be explained by the high molecular weight of the polymer and/or the strong interaction of the electron donating dimethoxyphenylene groups and electron accepting diimide groups in the polymer. (c) 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019

Welcome to talk about 87-41-2, If you have any questions, you can contact Tan, LY; Takeuchi, D; Osakada, K or send Email.. Recommanded Product: Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem