Category: 87-41-2

Authors Sicignano, M; Schettini, R; Sica, L; Pierri, G; De Riccardis, F; Izzo, I; Maity, B; Minenkov, Y; Cavallo, L; Della Sala, G in WILEY-V C H VERLAG GMBH published article about VINYLOGOUS ALDOL REACTION; PHASE-TRANSFER CATALYSIS; GAUSSIAN-BASIS SETS; ASYMMETRIC-SYNTHESIS; PHTHALIDE-3-CARBOXYLIC ACID; ENANTIOSELECTIVE ADDITION; MACROCYCLIC POLYETHERS; ANNULATION REACTIONS; DENSITY FUNCTIONALS; ENOLATE ACTIVATORS in [Sicignano, Marina; Schettini, Rosaria; Sica, Luisa; Pierri, Giovanni; De Riccardis, Francesco; Izzo, Irene; Della Sala, Giorgio] Univ Salerno, Dipartimento Chim & Biol Adolfo Zambelli, Via Giovanni Paolo II 132, I-84084 Fisciano, SA, Italy; [Maity, Bholanath; Cavallo, Luigi] KAUST, KAUST Catalysis Ctr, KCC, Thuwal 239556900, Saudi Arabia; [Minenkov, Yury] MIPT, Inst Pereulok 9, Dolgoprudnyi 141700, Moscow Region, Russia in 2019, Cited 96. Formula: C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Invited for the cover of this issue are the groups of Giorgio Della Sala at the Universita degli Studi di Salerno and Luigi Cavallo at the King Abdullah University of Science and Technology. The image depicts the transition state involved in the crown ether catalyzed arylogous Michael reaction of phthalides. Read the full text of the article at 10.1002/chem.201900168.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Hewage, ANDP; Yao, HL; Nammalwar, B; Gnanasekaran, KK; Lovell, S; Bunce, RA; Eshelman, K; Phaniraj, SM; Lee, MM; Peterson, BR; Battaile, KP; Reitz, AB; Rivero, M in AMER CHEMICAL SOC published article about PROTEIN-PROTEIN INTERACTIONS; BACTERIOFERRITIN STRUCTURE; IRON-METABOLISM; BINDING; ANTIBIOTICS; FERREDOXIN; RESISTANCE; DYNAMICS; PROMOTES; GALLIUM in [Hewage, Achala N. D. Punchi; Eshelman, Kate] Univ Kansas, Dept Chem, 2030 Becker Dr, Lawrence, KS 66047 USA; [Yao, Huili; Rivero, Mario] Louisiana State Univ, Dept Chem, 229A Choppin Hall, Baton Rouge, LA 70803 USA; [Nammalwar, Baskar; Gnanasekaran, Krishna Kumar; Bunce, Richard A.] Oklahoma State Univ, Dept Chem, Stillwater, OK 74078 USA; [Lovell, Scott] Univ Kansas, Prot Struct Lab, 2034 Becker Dr, Lawrence, KS 66047 USA; [Phaniraj, Sahishna M.; Lee, Molly M.; Peterson, Blake R.] Univ Kansas, Dept Med Chem, 2034 Becker Dr, Lawrence, KS 66047 USA; [Battaile, Kevin P.] Hauptman Woodward Med Res Inst, IMCA CAT, 9700 South Cass Ave,Bldg 435A, Argonne, IL 60439 USA; [Reitz, Allen B.] Fox Chase Chem Divers Ctr Inc, 3805 Old Easton Rd, Doylestown, PA 18902 USA; [Nammalwar, Baskar] 10522 Parkdale Ave, San Diego, CA 92126 USA; [Gnanasekaran, Krishna Kumar] 4591 Gatineau Ave, Mississauga, ON L4Z 2R9, Canada; [Eshelman, Kate] 10 Waterview Blvd, Parsippany, NJ 07054 USA; [Lee, Molly M.] NCI, Hatfield CRC, Bldg 10, Bethesda, MD 20892 USA in 2019, Cited 60. Safety of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

The iron storage protein bacterioferritin (BfrB) is central to bacterial iron homeostasis. The mobilization of iron from BfrB, which requires binding by a cognate ferredoxin (Bfd), is essential to the regulation of cytosolic iron levels in P. aeruginosa. This paper describes the structure-guided development of small molecule inhibitors of the BfrB-Bfd protein-protein interaction. The process was initiated by screening a fragment library and followed by obtaining the structure of a fragment hit bound to BfrB. The structural insights were used to develop a series of 4-(benzylamino)- and 4-((3-phenylpropyl)amino)-isoindoline-1,3-dione analogs that selectively bind BfrB at the Bfd binding site. Challenging P. aeruginosa cells with the 4-substituted isoindoline analogs revealed a dose-dependent growth phenotype. Further investigation determined that the analogs elicit a pyoverdin hyperproduction phenotype that is consistent with blockade of the BfrB-Bfd interaction and ensuing irreversible accumulation of iron in BfrB, with concomitant depletion of iron in the cytosol. The irreversible accumulation of iron in BfrB prompted by the 4-substituted isoindoline analogs was confirmed by visualization of BfrB-iron in P. aeruginosa cell lysates separated on native PAGE gels and stained for iron with Ferene S. Challenging P. aeruginosa cultures with a combination of commercial fluoroquinolone and our isoindoline analogs results in significantly lower cell survival relative to treatment with either antibiotic or analog alone. Collectively, these findings furnish proof of concept for the usefulness of small molecule probes designed to dysregulate bacterial iron homeostasis by targeting a protein-protein interaction pivotal for iron storage in the bacterial cell.

Safety of Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Hewage, ANDP; Yao, HL; Nammalwar, B; Gnanasekaran, KK; Lovell, S; Bunce, RA; Eshelman, K; Phaniraj, SM; Lee, MM; Peterson, BR; Battaile, KP; Reitz, AB; Rivero, M or send Email.

Reference:
Benzofuran – Wikipedia,
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I found the field of Chemistry; Science & Technology – Other Topics very interesting. Saw the article Manganese catalyzed selective hydrogenation of cyclic imides to diols and amines published in 2020. SDS of cas: 87-41-2, Reprint Addresses Milstein, D (corresponding author), Weizmann Inst Sci, Dept Organ Chem, IL-76100 Rehovot, Israel.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Herein we report the selective hydrogenation of cyclic imides to diols and amines, homogeneously catalyzed for the first time by a complex of an earth-abundant metal, a manganese pincer complex. A plausible catalytic cycle is proposed based on informative mechanistic experiments.

SDS of cas: 87-41-2. Welcome to talk about 87-41-2, If you have any questions, you can contact Das, UK; Janes, T; Kumar, A; Milstein, D or send Email.

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Benzofuran – Wikipedia,
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Adil, M; Ren, XX; Jeong, BR in [Adil, Muhammad; Jeong, Byoung Ryong] Gyeongsang Natl Univ, Inst Agr & Life Sci, Jinju 52828, South Korea; [Ren, Xiuxia; Jeong, Byoung Ryong] Gyeongsang Natl Univ, Div Appl Life Sci, Dept Hort, Grad Sch,BK Plus Program 21, Jinju 52828, South Korea; [Jeong, Byoung Ryong] Gyeongsang Natl Univ, Res Inst Life Sci, Jinju 52828, South Korea; [Adil, Muhammad] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem Biotechnol Wing, Karachi 75270, Pakistan published Light elicited growth, antioxidant enzymes activities and production of medicinal compounds in callus culture of Cnidium officinale Makino in 2019, Cited 45. Recommanded Product: Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Cnidium officinale Makino is an important medicinal plant of oriental clinics and is considered as the main source of phthalides, polyphenols, and flavonoids. However, there is no available report regarding the effect of different light colors on the secondary metabolites composition of C. officinale. In this study different light (dark, white, blue, red and red: blue) conditions were arranged to raise callus on MS medium containing 0.5 mg.L-1 of each 2,4-D and BAP. Callus grown in dark condition showed maximum (2.0 g) fresh weight with lower total phenolic and flavonoids contents. Also, in dark condition callus faced higher catalase (CAT) and guaiacol peroxidase (GPX) activities to avoid free radicals. Mix (red: blue) light condition favored the synthesis of phenolics and flavonoids in callus at the cost of higher ascorbate peroxidase (APX) and superoxide dismutase (SOD) enzymes expression. However, DPPH free radical scavenging activity was less variable among the samples from the different light conditions. Interestingly, the HPLC profile showed higher (28.3 mu g.g(-1) DW) phthalide accumulation in dark grown-cultures. Compared to other light conditions, 3-butyledinephthalide accumulation was higher (0.43 mu g-g(-1) DW) in white light-grown callus. These findings suggest that light conditions play an important role in the regulation of in vitro callus growth and synthesis of important medicinal compounds of C. officinale.

Welcome to talk about 87-41-2, If you have any questions, you can contact Adil, M; Ren, XX; Jeong, BR or send Email.. Recommanded Product: Isobenzofuran-1(3H)-one

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry very interesting. Saw the article Aniline-Type Hypervalent Iodine(III) for Intramolecular Cyclization via C-H Bond Abstraction of Hydrocarbons Containing N- and O-Nucleophiles published in 2021. Product Details of 87-41-2, Reprint Addresses Moriyama, K (corresponding author), Chiba Univ, Grad Sch Sci, Dept Chem, Inage Ku, 1-33 Yayoi Cho, Chiba 2638522, Japan.; Moriyama, K (corresponding author), Chiba Univ, Soft Mol Activat Res Ctr, Inage Ku, 1-33 Yayoi Cho, Chiba 2638522, Japan.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

We developed a method for the preparation of (diacetoxyiodo)-2-(N-alkylamido)benzene as an aniline-type hypervalent iodine(III). We also achieved direct cyclizations via C-H bond abstraction, such as the Hofmann-Loffler-Freytag reaction, a direct amination, and a direct lactonization, using the aniline-type hypervalent iodine(III) to obtain corresponding products in high yields.

Welcome to talk about 87-41-2, If you have any questions, you can contact Nishiguchi, Y; Moriyama, K or send Email.. Product Details of 87-41-2

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Stecoza, CE; Draghici, C; Caproiu, MT; Pircalabioru, GG; Marutescu, L in [Stecoza, Camelia Elena] Carol Davila Univ Med & Pharm, Fac Pharm, Dept Pharmaceut Chem, 6 Traian Vuia St, Bucharest 020956, Romania; [Draghici, Constantin; Caproiu, Miron Teodor] Costin D Nenitescu Ctr Organ Chem Romanian Acad, 202 B Splaiul Independentei, Bucharest 060023, Romania; [Pircalabioru, Gratiela Gradisteanu; Marutescu, Luminita] Univ Bucharest, Res Inst, Bucharest 60101, Romania published SYNTHESIS AND EVALUATION OF THE ANTIMICROBIAL AND ANTIBIOFILM ACTIVITY OF NOVEL DIBENZOTHIEPINES in 2020, Cited 21. HPLC of Formula: C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Considering the anti-infective potential of compounds containing the dibenzothiepine scaffold, we set out to obtain new compounds bearing this structure. The synthesized compounds were characterized by spectral studies and elemental analysis and screened for their microbiostatic/microbicidal and antibiofilm properties against reference and clinical microbial strains. The new compounds exhibited a broad spectrum of antimicrobial activity, which was more intensive for the S-oxidized compounds. Some of the compounds also inhibited the ability of the investigated strains to form biofilms on the inert substratum.

HPLC of Formula: C8H6O2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Aldehyde effect and ligand discovery in Ru-catalyzed dehydrogenative cross-coupling of alcohols to esters WOS:000460683700012 published article about ACCEPTORLESS DEHYDROGENATION; ALIPHATIC-ALCOHOLS; COMPLEXES; OXIDATION; ESTERIFICATION in [Jiang, Xiaolin; Zhao, Dongmei] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China; [Jiang, Xiaolin; Zhang, Jiahui; Li, Yuehui] Chinese Acad Sci, State Key Lab Oxo Synth & Select Oxidat, Lanzhou Inst Chem Phys, Suzhou Res Inst LICP, Lanzhou 730000, Peoples R China; [Zhang, Jiahui] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China in 2019, Cited 25. Name: Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

The presence of different aldehydes is found to have a significant influence on the catalytic performance when using PN(H)P type ligands for dehydrogenation of alcohols. Accordingly, hybrid multi-dentate ligands were discovered based on an oxygen-transfer alkylation of PNP ligands by aldehydes. The relevant Ru-PNN(PO) system provided the desired unsymmetrical esters in good yields via acceptorless dehydrogenation of alcohols. Hydrogen bonding interactions between the phosphine oxide moieties and alcohol substrates likely assisted the observed high chemoselectivity.

Welcome to talk about 87-41-2, If you have any questions, you can contact Jiang, XL; Zhang, JH; Zhao, DM; Li, YH or send Email.. Name: Isobenzofuran-1(3H)-one

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Application In Synthesis of Isobenzofuran-1(3H)-one. Xin, MH; Sun, JJ; Huang, W; Tang, F; Liu, ZY; Jin, Q; Wang, J in [Xin, Minhang; Sun, Jiajia] Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Pharm, Dept Med Chem, 76 Yanta West Rd, Xian 710061, Peoples R China; [Huang, Wei] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China; [Tang, Feng; Liu, Zhaoyu; Jin, Qiu; Wang, Jia] Jiangsu Simcere Pharmaceut Co Ltd, 699-18 Xuan Wu Dist, Nanjing 210042, Peoples R China published Design and synthesis of novel phthalazinone derivatives as potent poly(ADP-ribose)polymerase 1 inhibitors in 2020, Cited 22. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Aim:The development of effective PARP-1 inhibitors has received great enthusiasm in medicinal chemistry communities.Results:A new series of novel phthalazinone derivatives were designed and synthesized. Among these,B1andB16displayed more potent PARP-1 inhibitory activities than olaparib.B16gave an IC(50)value of 7.8 nM against PARP-1, and a PF(50)value of 3.4 in the sensitizing effect assay. Thein vivopharmacokinetic properties evaluation showedB16displayed insufficient oral exposure, and it was also not stable in rat blood.Conclusion:The results indicated that our design phthalazinone derivatives were potent PARP-1 inhibitors, and compoundB16was a valuable lead compound with siginificantin vitroefficacy, deseaving further optimization so as to develop anticancer drug candidate.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Computed Properties of C8H6O2. Capolupo, M; Sorensen, L; Jayasena, KD; Booth, AM; Fabbri, E in [Capolupo, Marco; Jayasena, Kongalage Don Ranil; Fabbri, Elena] Univ Bologna, Dept Biol Geol & Environm Sci, Via St Alberto 163, I-48123 Ravenna, Italy; [Sorensen, Lisbet; Booth, Andy M.] SINTEF Ocean Environm & New Resources, Postboks 4762, N-7465 Trondheim, Norway published Chemical composition and ecotoxicity of plastic and car tire rubber leachates to aquatic organisms in 2020, Cited 66. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Synthetic polymer-based materials are ubiquitous in aquatic environments, where weathering processes lead to their progressive fragmentation and the leaching of additive chemicals. The current study assessed the chemical content of freshwater and marine leachates produced from car tire rubber (CTR), polypropylene (PP), polyethylene terephthalate (PET), polystyrene (PS) and polyvinyl chloride (PVC) microplastics, and their adverse effects on the microalgae Raphidocelis subcapitata (freshwater) and Skeletonema costatum (marine) and the Mediterranean mussel Mytilus galloprovincialis. A combination of non-target and target chemical analysis revealed a number of organic and metal compounds in the leachates, including representing plasticizers, antioxidants, antimicrobials, lubricants, and vulcanizers. CTR and PVC materials and their corresponding leachates had the highest content of tentatively identified organic additives, while PET had the lowest. The metal content varied both between polymer leachates and between freshwater and seawater. Notable additives identified in high concentrations were benzothiazole (CTR), phthalide (PVC), acetophenone (PP), cobalt (CTR, PET), zinc (CTR, PVC), lead (PP) and antimony (PET). All leachates, except PET, inhibited algal growth with EC50 values ranging from 0.5% (CTR) and 64% (PP) of the total leachate concentration. Leachates also affected mussel endpoints, including the lysosomal membrane stability and early stages endpoints as gamete fertilization, embryonic development and larvae motility and survival. Embryonic development was the most sensitive parameter in mussels, with EC50 values ranging from 0.8% (CTR) to 65% (PET) of the total leachate. The lowest impacts were induced on D-shell larvae survival, reflecting their ability to down-regulate motility and filtration in the presence of chemical stressors. This study provides evidence of the relationship between chemical composition and toxicity of plastic/rubber leachates. Consistent with increasing contamination by organic and inorganic additives, the leachates ranged from slightly to highly toxic to mussels and algae, highlighting the need for a better understanding of the overall impact of plastic-associated chemicals on aquatic ecosystems. (C) 2019 The Authors. Published by Elsevier Ltd.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article The Effect of Packing Material Properties on Tars Removal by Plasma Catalysis WOS:000601891100001 published article about NONTHERMAL PLASMA; MODEL-COMPOUND; BIOMASS GASIFICATION; NAPHTHALENE DECOMPOSITION; DISCHARGE CHARACTERISTICS; HETEROGENEOUS CATALYSIS; TOTAL OXIDATION; CARBON-DIOXIDE; PRODUCER GAS; CO2 in [Cimerman, Richard; Cibikova, Maria; Hensel, Karol] Comenius Univ, Fac Math Phys & Informat, Dept Astron Phys Earth & Meteorol, Mlynska Dolina F2, Bratislava 84248, Slovakia; [Satrapinskyy, Leonid] Comenius Univ, Fac Math Phys & Informat, Dept Expt Phys, Mlynska Dolina F2, Bratislava 84248, Slovakia in 2020, Cited 108. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Category: benzofurans

Plasma catalysis has been utilized in many environmental applications for removal of various hydrocarbons including tars. The aim of this work was to study the tars removal process by atmospheric pressure DBD non-thermal plasma generated in combination with packing materials of various composition and catalytic activity (TiO2, Pt/gamma Al2O3, BaTiO3, gamma Al2O3, ZrO2, glass beads), dielectric constant (5-4000), shape (spherical and cylindrical pellets and beads), size (3-5 mm in diameter, 3-8 mm in length), and specific surface area (37-150 m(2)/g). Naphthalene was chosen as a model tar compound. The experiments were performed at a temperature of 100 degrees C and a naphthalene initial concentration of approx. 3000 ppm, i.e., under conditions that are usually less favorable to achieve high removal efficiencies. For a given specific input energy of 320 J/L, naphthalene removal efficiency followed a sequence: TiO2 > Pt/gamma Al2O3 > ZrO2 > gamma Al2O3 > glass beads > BaTiO3 > plasma only. The efficiency increased with the increasing specific surface area of a given packing material, while its shape and size were also found to be important. By-products of naphthalene decomposition were analyzed by means of FTIR spectrometry and surface of packing materials by SEM analysis.

Category: benzofurans. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem