Category: 87-41-2

Das, UK; Janes, T; Kumar, A; Milstein, D in [Das, Uttam Kumar; Janes, Trevor; Kumar, Amit; Milstein, David] Weizmann Inst Sci, Dept Organ Chem, IL-76100 Rehovot, Israel; [Kumar, Amit] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland published Manganese catalyzed selective hydrogenation of cyclic imides to diols and amines in 2020, Cited 43. Recommanded Product: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Herein we report the selective hydrogenation of cyclic imides to diols and amines, homogeneously catalyzed for the first time by a complex of an earth-abundant metal, a manganese pincer complex. A plausible catalytic cycle is proposed based on informative mechanistic experiments.

Recommanded Product: 87-41-2. Welcome to talk about 87-41-2, If you have any questions, you can contact Das, UK; Janes, T; Kumar, A; Milstein, D or send Email.

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Authors Liang, XY; Yu, P; Fu, C; Shen, YC in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Liang, Xiayu; Yu, Peng; Fu, Chen; Shen, Yongcun] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, 122 Luoshi Rd, Wuhan 430070, Peoples R China in 2021, Cited 31. Product Details of 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

A new strategy for the facile synthesis of hydroxyalkylamides through the ring-opening reaction of lactone with amine promoted by dibutyltin acetate was developed. A series of hydroxyalkylamide compounds were obtained and the method was successfully applied to the synthesis of pharmaceutically active molecules tyrosinase inhibitor V and HDAC inhibitor VI via a three-step synthetic pathway. The broad substrate scope, mild reaction conditions and practical application proved the effectiveness, compatibility and practicality of this method. (C) 2021 Elsevier Ltd. All rights reserved.

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COA of Formula: C8H6O2. Recently I am researching about PATHWAY CONTRIBUTES; STROKE; INJURY; NEUROGENESIS; LIGUSTILIDE; DEFICITS; KLOTHO, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81072636, 81473219]; Sichuan Science and Technology Programs [2014JY0151, 20185Z0015]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities; 111 Project of the National Ministry of Education [B18035]. Published in ELSEVIER in AMSTERDAM ,Authors: Gan, YM; Liu, DL; Chen, C; Duan, W; Yang, YX; Du, JR. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Microglia can be activated to become the classic phenotype (M1) or alternative phenotype (M2), which play an important role in regulating neuroinflammatory response and tissue repair after ischemic stroke. CD21, a novel phthalide derivative, is a potential neuroprotectant against ischemic brain injury. The present study further investigated the effects of CD21 on post-ischemic microglial polarization and the underlying mechanisms. Transient middle cerebral artery occlusion (tMCAO) was used as a mouse model of ischemic stroke, while BV2 cells stimulated with conditioned medium collected from oxygen-glucose deprivation-treated HT22 cells were used in in vitro ischemic studies. The current results showed that CD21 dose-dependently and significantly improved neurological outcomes in tMCAO mice. Biochemical analyses revealed that CD21 decreased the expression of M1 phenotype markers (CD86, interleukin-1 beta and inducible nitric oxide synthase) and increased the expression of M2 phenotype markers (CD206, interleukin-10 and YM1/2) in both ischemic brain tissues and BV2 cells. Meanwhile, CD21 decreased the production of proinflammatory cytokines (interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha), promoted the release of the antiinflammatory cytokine (interleukin-10), and enhanced the phosphorylation of adenosine 5′-monophosphate-activated protein kinase (AMPK) in ischemic brain tissue and BV2 cells. Furthermore, the AMPK inhibitor (compound C) reversed these effects of CD21 in BV2 cells. These findings indicate that CD21 alleviates post-ischemic neuroinflammation through induction of microglial M2 polarization that is at least in part medicated by AMPK activation, suggesting that CD21 may be a promising candidate for protecting against ischemic brain injury.

COA of Formula: C8H6O2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about ACTIVATED CARBON; SELECTIVE HYDROGENATION; GRAPHENE OXIDE; NITROGEN; OXIDATION; NITROBENZENE; NANOTUBES; PERFORMANCE; SITES; ELECTRODES, Saw an article supported by the National Key R&D Program of China [2016YFE0203500]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [U1510122]; Foundation of State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering [2017-K11]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M631777]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Wei, QH; Qin, FF; Ma, QX; Shen, WZ. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one. HPLC of Formula: C8H6O2

Nitroarenes reduction is an important technology in the industrial production of aminoarenes. In this work, we presented an environment-friendly and low-cost green synthesis route for preparation of oxygen and nitrogen co-doped porous carbon (ONPC) via acid oxidation and alkali activation methods using coal tar- and residual oil-based as starting materials, and the prepared ONPC was employed as metal-free carbon catalyst for nitroarenes reduction to aminoarenes in the presence of hydrazine hydrate. This ONPC catalyst showed much higher catalytic activity as compared to those of un-doped porous carbon (PC), activated carbon (AC) and carbon black, which was attributed to its large surface area and developed pore structure as well as O and N co-doping. Additionally, it also exhibited a versatility in various aromatic nitro-compounds reduction to relative aromatic amines. Experimental results by using model catalysts to simulate different carbons with various oxygen-containing groups proved that carbonyl groups were more favorable for nitrobenzene reduction to aniline. Upon co-doping O and N into PC, the two kinds of introduced species synergistically promoted the catalytic activity of PC. Good performance together with low-cost preparation makes oxygen and nitrogen co-doped porous carbon a potential substitution of supported metal catalyst for nitroarenes reduction. (C) 2018 Elsevier Ltd. All rights reserved.

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An article Phthalide derivative CD21 ameliorates ischemic brain injury in a mouse model of global cerebral ischemia: involvement of inhibition of NLRP3 WOS:000565183600002 published article about ISCHEMIA/REPERFUSION INJURY; INFLAMMASOME ACTIVATION; LIGUSTILIDE; STROKE; NEUROTOXICITY; PATHWAY; RATS in [Li, Xin; Shi, Meng-Qi; Du, Jun-Rong] Sichuan Univ, Educ Minist, Sichuan Engn Lab Plant Sourced Drug, Dept Pharmacol,Key Lab Drug Targeting & Drug Deli, Chengdu 610041, Peoples R China; [Li, Xin; Shi, Meng-Qi; Du, Jun-Rong] Sichuan Univ, West China Sch Pharm, Sichuan Res Ctr Drug Precis Ind Technol, Chengdu 610041, Peoples R China; [Chen, Chu] Sichuan Acad Chinese Med Sci, Chengdu 610041, Peoples R China in 2020, Cited 43. Computed Properties of C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

The activation of NLRP3 inflammasome is closely related to ischemic brain injury and inhibition of NLRP3 inflammasome activation may be a new therapeutic strategy for ischemic stroke. Our previous studies showed that ligustilide (LIG) had a dose-dependent neuroprotective effect on various models of cerebral ischemia and dementia in vivo and in vitro. CD21, a kind of phthalide derivative, was modified from LIG. In this study, we established a global cerebral ischemia-reperfusion model in mice by bilateral common carotid artery ligation (2VO), and explored the neuroprotective effect of CD21 and its anti-inflammatory mechanism on cerebral ischemia mice. CD21 significantly improved weight loss, neurobehavioral deficits and neurons loss in hippocampal CA1 and caudate putamen (CPu) subregions, which were induced by 2VO in mice. CD21 significantly inhibited the overactivation of astrocyte and microglia, and decreased the mRNA level of IL-6, TNF-alpha and IL-1 beta. Moreover, CD21 significantly inhibited the activation of TLR4/NF-kappa B signaling pathway mediated by HMGB1 and NLRP3/ASC/Caspase-1 signaling pathway mediated by Cathepsin B, thus inhibiting the activation of NLRP3 inflammasome. Our results demonstrated that CD21 may exert a neuroprotection by inhibiting NLRP3 inflammasome activation after cerebral ischemia. These findings provide a new strategy for the treatment of ischemic stroke.

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Benzofuran – Wikipedia,
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I found the field of Chemistry; Physics very interesting. Saw the article Application of polar solvent effects in absorption spectra for determination of lowest electron-excited states of phthalide published in 2019. Safety of Isobenzofuran-1(3H)-one, Reprint Addresses Tseplin, EE (corresponding author), Russian Acad Sci, Ufa Fed Res Ctr, Inst Mol & Crystal Phys, Prospekt Oktyabrya 151, Ufa 450075, Russia.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

The optical absorption spectra of phthalide in polar (methanol) and nonpolar (n-hexane) solvents are recorded. The electronic phthalide spectrum was calculated by TDDFT B3LYP/6-311 + G(d, p) using the polarisable continuum model. Based on an analysis of calculation data and the displacement of absorption bands in a polar solvent, it was established that the absorption bands of phthalide at energies of 3.51 and 3.96 eV correspond to singlet-triplet transitions to the T-1 and T-2 states, respectively.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Backer, BS; Choy, CJ; Davis, AL; Browne, ZS; Berkman, CE in [Backer, Brian S.; Choy, Cindy J.; Davis, Austen L.; Browne, Zachery S.; Berkman, Clifford E.] Washington State Univ, Dept Chem, Pullman, WA 99164 USA published Tunable pH-sensitive 2-carboxybenzyl phosphoramidate cleavable linkers in 2020, Cited 28. Safety of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

We previously described a pH-sensitive phosphoramidate linker scaffold that can be tuned to release amine-containing drugs at various pH values. In these previous studies it was determined that the tunability of this linker was dependent upon the proximity of an acidic group (e.g., carboxylic acid or pyridinium). In this study, we confirmed that the tunability of pH-triggered amine-release was also dependent upon the pK(a) of the proximal acidic group. A series of 2-carboxybenzyl phosphoramidates was prepared in which the pK(a) of the proximal benzoic acid was predictably attenuated by substituents on the benzoate ring consistent with their sigma-values. (C) 2020 Elsevier Ltd. All rights reserved.

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Benzofuran – Wikipedia,
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Computed Properties of C8H6O2. Li, J; Bao, WH; Tang, ZC; Guo, BD; Zhang, SW; Liu, HL; Huang, SP; Zhang, Y; Rao, YJ in [Li, Jia; Bao, Wenhao; Tang, Zhaocheng; Guo, Baodang; Liu, Haili; Rao, Yijian] Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Carbohydrate Chem & Biotechnol, Wuxi 214122, Jiangsu, Peoples R China; [Zhang, Shiwei; Zhang, Yan] Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Jiangsu, Peoples R China; [Huang, Shuping] Fuzhou Univ, Coll Chem, Fuzhou 350108, Fujian, Peoples R China published Cercosporin-bioinspired selective photooxidation reactions under mild conditions in 2019, Cited 132. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

The development of an efficient system for selective oxidation of organic compounds to generate more valuable compounds with molecular oxygen is a significant challenge in industrial chemistry. Bioinspired by the ability of naturally occurring perylenequinonoid pigments (PQPs) to generate reactive oxygen species (ROS) upon photoirradiation, here we report that cercosporin, one of the perylenequinonoid pigments, can function as a cost-effective and environmentally friendly photocatalyst for a wide range of selective oxidations, including benzylic C-H bonds to carbonyls, amines to aldehydes, and sulfides to sulfoxides. All of the representative reactions proceeded smoothly with high efficiency under mild conditions. Owing to the use of inexpensive metal-free visible light-driven photocatalyst produced from microbial fermentation with cheap glucose as the starting material and the ease of handling, we expect that this developed method will be particularly attractive for many more applications in synthetic transformation.

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I found the field of Chemistry very interesting. Saw the article Synthesis and Photodimerization of 2-and 2,3-Disubstituted Anthracenes: Influence of Steric Interactions and London Dispersion on Diastereoselectivity published in 2019. SDS of cas: 87-41-2, Reprint Addresses Bettinger, HF (corresponding author), Eberhard Karls Univ Tubingen, Inst Organ Chem, Morgenstelle 18, D-72076 Tubingen, Germany.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

There is increased evidence that the effect of bulky groups in organic, organometallic, and inorganic chemistry is not only repulsive but can be attractive because of London dispersion interactions. The influence of the size of primary alkyl substituents in 2- ‘ and 2,3-positions of anthracenes on the diastereoselectivity (anti vs syn dimer) of the [pi(4s) + pi(4s)] photoinduced dimerization is investigated. The synthesis of the anthracene derivatives was achieved by Suzuki-Miyaura reaction of 2,3-dibromoanthracene with alkylboronic acids as well as by reduction of anthraquinones that were obtained from 2,3-disubstituted 1,3-butadienes and naphthoquinone followed by dehydrogenation. The mixtures of dianthracene isomers were analyzed with respect to the anti/syn-ratio of the products by X-ray crystallography and nuclear Overhauser effect spectroscopy. While for the 2,3-dimethylanthracene the anti and syn isomers were formed in equal amounts, the anti dimers are the major products in all other cases. A linear correlation (R-2 = 0.98) between the steric size (Charton parameter) and the isomeric ratio suggests that the selectivity is dominated by classical repulsive steric effects. An exception is the iso-butyl substituent that produces an increased amount of the syn isomer. It is suggested that this is due to an exalted effect of London dispersion interactions.

SDS of cas: 87-41-2. Welcome to talk about 87-41-2, If you have any questions, you can contact Geiger, T; Haupt, A; Maichle-Mossmer, C; Schrenk, C; Schnepf, A; Bettinger, HF or send Email.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Shaalan, Y; Boulton, L; Jamieson, C in AMER CHEMICAL SOC published article about in [Shaalan, Youssef; Boulton, Lee] GlaxoSmithKline Med Res Ctr, Chem Dev, Stevenage SG1 2NY, Herts, England; [Shaalan, Youssef; Jamieson, Craig] Univ Strathclyde, Dept Pure & Appl Chem, Glasgow G1 1XL, Lanark, Scotland in 2020, Cited 39. Quality Control of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Ruthenium pincer complexes were synthesized and used for catalytic ester reductions under mild conditions (similar to 5 bar of hydrogen). An experimental design approach was used to optimize the conditions for yield, purity, and robustness. Evidence for the catalytically active ruthenium dihydride species is presented. Observed intermediates and side products, as well as time-course data, were used to build mechanistic insight. The optimized procedure was further demonstrated through scaled-up reductions of two pharmaceutically relevant esters, both in batch and continuous flow.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem