Category: 6807-83-6

Flavonoids and phenolic acids from the roots of Sophora tonkinensis Gagnep was written by Hou, Mengyang;Hu, Wenzhong;Hao, Kexin;Xiu, Zhilong. And the article was included in Biochemical Systematics and Ecology in 2020.Product Details of 6807-83-6 This article mentions the following:

Phytochem. study on the roots of Sophora tonkinensis Gagnep. led to the isolation of fifteen compounds, including eleven flavonoids (1-11) and four phenolic acids (12-15). The structures of these compounds were elucidated based on NMR and HR-ESIMS anal., further supported by comparison with previous literatures. Among them, compounds 2, 3, 4, 6, 9, 12 and 13 were firstly discovered from S. tonkinensis, compound 8 was firstly discovered from the genus Sophora. Furthermore, the chemotaxonomic significance of the obtained compounds was discussed in detail. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6Product Details of 6807-83-6).

(2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Product Details of 6807-83-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In-vivo study of metabolism of trifolirhizin in rats was written by Chen, Lei;Liu, Yi;Zhang, Honggui;Liang, Shengwang. And the article was included in Zhongyao Xinyao Yu Linchuang Yaoli in 2012.Product Details of 6807-83-6 This article mentions the following:

Objective: To investigate the principal metabolites of trifolirhizin in rats after intragastric (ig) administration by HPLC-MSⁿ, and to propose their metabolic pathways. Methods: Urine and stool of the rats were collected after administration for the comprehensive anal. of chromatog. retention time and electrospray mass spectrometry and multistage level information of the metabolites, and the results were compared with the reference substance. Results: Maackiain and maackiain-3-O-sulfoacid were identified in urine, and maackiain was identified in feces after trifolirhizin ig administration. Conclusion: Extensive metabolism of trifolirhizin has been shown in rats after ig administration, and the metabolic pathway of the metabolites has been proposed. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6Product Details of 6807-83-6).

(2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Product Details of 6807-83-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Effect of the ethyl acetate extract of Sophora flavescens Aiton on diabetic retinopathy based on untargeted retinal metabolomics was written by Luo, Yun;Zhao, Kairui;Li, Zhaocheng;Gao, Yanping;Lin, Minling;Li, Yadi;Wang, Shumei;Liu, Yi;Chen, Lei. And the article was included in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences in 2022.Reference of 6807-83-6 This article mentions the following:

Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and a leading cause of vision impairment and blindness, which lacks effective diagnostic measures and therapeutic options. Sophora flavescens Aiton or “Kushen” is a traditional Chinese medicine used since ancient times, either alone or in combination, to clear heat, dampness, and tearing, and to treat ocular diseases and improve eyesight. Addnl., the flavonoids of Sophora flavescens Aiton extracted using Et acetate (EtOAc) (SFE) is effective in managing diabetes and diabetic vascular complications. In this study, we explored the pharmacodynamic effects and material basis of action of SFE on DR for the first time and elucidated the mechanism based on untargeted retinal metabolomics. Results from the pharmacodynamic studies showed that SFE could reduce blood glucose levels in rats, regulate serum lipopolysaccharide, tauroursodeoxycholic acid, and trimethylamine oxide levels, and significantly improve the structure of retina in rats with DR. Moreover, SFE could protect the blood-retinal barrier, reduce angiogenesis and capillary formation, and inhibit retinal nerve cell apoptosis. A total of 13 compounds were identified in the aqueous humor and retina, which were dihydroflavonoid, isoflavonoid, pterostane flavonoid, chalcone, and dihydroflavonol derivatives In addition, 39 differential metabolites were screened based on retinal metabolomics data and 23 were found to be affected by SFE, indicating its anti-DR effect by regulating the synthetic metabolic pathways, including lactose, bile acid, glycerophospholipid, arginine, purine, and pyrimidine metabolism pathways. Collectively, our findings elucidated the effects, material basis, and treatment mechanism of SFE on DR systematically and could lay the foundation for promoting the clin. application of Sophora flavescens Aiton. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6Reference of 6807-83-6).

(2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Reference of 6807-83-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

HPLC determination of trifolirhizin in Sophora flavescens Ait. was written by Zhao, Huijuan;Wang, Daqi;Sun, Wenji. And the article was included in Yaowu Fenxi Zazhi in 2005.Name: (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol This article mentions the following:

An HPLC method for determination of trifolirhizin in Sophora flavescens Ait was established. SUPELCO C₁₈ column (25 cm×4.6 mm, 5 μm) was used, and the mobile phase consisted of MeOH-H₂O (1:1). The flow rate was 1.0 mL·min^-1, and the determination wavelength was 310 nm. The linear range was 0.41-4.10 μg (r=0.9998). The average recoveries were 98.72%, 99.20% and 99.47%; and RSD was 1.1%, 1.5% and 2.2% (n=3), resp. This method is simple, rapid and reliable for determination of trifolirhizin in Sophora flavescens Ait. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6Name: (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol).

(2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Name: (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem