Category: 652-39-1

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High-resolution spectroscopic study of matrix-isolated reactive intermediates: Vibrational assignments for 3-fluoro-o-benzyne and perfluoro-o-benzyne

A novel “site decompression technique” that takes advantage of specific pressure relaxation effects in cryogenic noble gas matrices was applied in a spectroscopic investigation of the two title compounds, resulting in virtually background-free, complete, high-resolution IR spectra with line widths of ca. 0.1 cm-1. The compounds were prepared photochemically in Ar and Ne matrices and, together with the related intermediates, fluorinated benzocyclopropenone and cyclopentadienylideneketene, characterized by IR and UV-visible absorption spectroscopy. Weak IR absorption bands observed at 1878 cm-1 for perfluoro-o-benzyne and at 1866 cm-1 for 3-fluoro-o-benzyne were assigned to CC triple bond stretching vibrations, corresponding to the transition at 1846 cm-1 in the parent o-benzyne. The application of polarization spectroscopy on photooriented samples led to the determination of transition moment directions for most of the observed vibrational transitions. Absolute IR absorption intensities were also obtained. The assignments of the observed transitions were supported by the results of B3LYP/cc-pVDZ quantum chemical calculations.

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Benzofuran – Wikipedia,
Benzofuran | C8H2550O – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. HPLC of Formula: C8H3FO3. Introducing a new discovery about 652-39-1, Name is 4-Fluoroisobenzofuran-1,3-dione

MACROCYCLIC HEPATITIS C PROTEASE INHIBITORS

The present invention provides novel macrocyclic compounds that mimic peptide substrates of the hepatitis C viral protease and inhibit the viral protease, more particularly as inhibitors of the NS3 serine protease from hepatitis C virus. Methods for synthesis of the compounds are also provided. The compounds find utility as antiviral agents directed at hepatitis C. The invention further provides methods of employing such inhibitors, alone or in combination with other therapeutic agents, to treat hepatitis C infection in a subject in need of such treatment.

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Benzofuran – Wikipedia,
Benzofuran | C8H2464O – PubChem

652-39-1, Name is 4-Fluoroisobenzofuran-1,3-dione, belongs to benzofuran compound, is a common compound. category: benzofuranIn an article, once mentioned the new application about 652-39-1.

Polyurethane dispersant and the method for its preparation

The present invention is related to a polyurethane dispersant and a preparation method thereof. The polyurethane dispersant is terminated by a nitrogen-containing heterocyclic compound during synthesis. The nitrogen-containing heterocyclic compound is prepared by subjecting anhydride and a compound containing a primary amine and a secondary amine or a hydroxyl or mercapto group to dehydration condensation. The condensed product is the nitrogen-containing heterocyclic compound, containing a reactive hydrogen. The structural formula of the compound containing the primary amine and the secondary amine or hydroxyl or mercapto group is shown as follows: wherein n=1 to 5, and preferably 2 to 4, R1 and R2 are respectively alkyls containing 1 to 8 carbons, R1 and R2 are independent of each other or connected by a chemical bond to form one or more saturated or unsaturated 4-member to 8-member rings, and X represents N, O, or S.

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Benzofuran – Wikipedia,
Benzofuran | C8H2500O – PubChem

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BENZODIOXANE DERIVATIVES AND THEIR PHARMACEUTICAL USE

Compounds of formula (I): wherein Ra and Rb are as defined in the claims, exhibit alpha2C antagonistic activity and are thus useful as alpha2C antagonists.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H2481O – PubChem

652-39-1, Name is 4-Fluoroisobenzofuran-1,3-dione, belongs to benzofuran compound, is a common compound. Formula: C8H3FO3In an article, once mentioned the new application about 652-39-1.

Structure-activity relationships of a series of substituted benzamides: Potent D2/5-HT2 antagonists and 5-HT1a agonists as neuroleptic agents

A series of substituted (4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)benzamide derivatives was prepared and evaluated as potential atypical antipsychotic agents. The target compounds were readily prepared from their benzoyl chloride, benzoic acid, or isatoic anhydride precursors, and they were evaluated in vitro for their ability to bind to dopamine D2, serotonin 5-HT2, and serotonin 5-HT1a receptors. To assess the potential antipsychotic activity of these compounds, we investigated their ability to inhibit the apomorphine-induced climbing response in mice. Selected compounds were evaluated further to determine their side-effect potentials. Structure-activity relationships of both mono- and polysubstituted benzamides are discussed herein. While several analogues had potent in vitro and in vivo activities indicative of potential atypical antipsychotic activity, anthranilamide 77 (1192U90) demonstrated a superior pharmacological profile. As a result of this investigation, 1192U90 (2-amino-N-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)benzamide hydrochloride) was selected for further evaluation and is currently in phase I clinical trials as a potential atypical antipsychotic agent.

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Benzofuran – Wikipedia,
Benzofuran | C8H2547O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: 4-Fluoroisobenzofuran-1,3-dione, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 652-39-1, Name is 4-Fluoroisobenzofuran-1,3-dione, molecular formula is C8H3FO3

Unmasking Amides: Ruthenium-Catalyzed Protodecarbonylation of N-Substituted Phthalimide Derivatives

The unprecedented transformation of a wide range of synthetically appealing phthalimides into amides in a single-step operation has been achieved in high yields and short reaction times using a ruthenium catalyst. Mechanistic studies revealed a unique, homogeneous pathway involving five-membered ring opening and CO2 release with water being the source of protons.

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Benzofuran – Wikipedia,
Benzofuran | C8H2567O – PubChem

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Chemical inactivation of the E3 ubiquitin ligase cereblon by pomalidomidebased homo-PROTACs

The immunomodulatory drugs (IMiDs) thalidomide and its analogs, lenalidomide and pomalidomide, all FDA approved drugs for the treatment of multiple myeloma, induce ubiquitination and degradation of the lymphoid transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) via the cereblon (CRBN) E3 ubiquitin ligase for proteasomal degradation. IMiDs have recently been utilized for the generation of bifunctional proteolysis targeting chimeras (PROTACs) to target other proteins for ubiquitination and proteasomal degradation by the CRBN E3 ligase. We designed and synthesized pomalidomide-based homobifunctional PROTACs and analyzed their ability to induce self-directed ubiquitination and degradation of CRBN. Here, CRBN serves as both, the E3 ubiquitin ligase and the target at the same time. The homo-PROTAC compound 8 degrades CRBN with a high potency with only minimal remaining effects on IKZF1 and IKZF3. CRBN inactivation by compound 8 had no effect on cell viability and proliferation of different multiple myeloma cell lines. This homo-PROTAC abrogates the effects of IMiDs in multiple myeloma cells. Therefore, our homodimeric pomalidomide-based compounds may help to identify CRBN?s endogenous substrates and physiological functions and investigate the molecular mechanism of IMiDs.

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Benzofuran – Wikipedia,
Benzofuran | C8H2539O – PubChem

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MACROCYCLIC CARBOXYLIC ACIDS AND ACYLSULFONAMIDES AS INHIBITORS OF HCV REPLICATION

The present invention provides compounds of the general formulas I-IX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The present invention further provides treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 652-39-1

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Benzofuran – Wikipedia,
Benzofuran | C8H2572O – PubChem

652-39-1, Name is 4-Fluoroisobenzofuran-1,3-dione, belongs to benzofuran compound, is a common compound. Recommanded Product: 4-Fluoroisobenzofuran-1,3-dioneIn an article, once mentioned the new application about 652-39-1.

MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF

The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I), wherein R1,R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

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Benzofuran – Wikipedia,
Benzofuran | C8H2502O – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Safety of 4-Fluoroisobenzofuran-1,3-dione. Introducing a new discovery about 652-39-1, Name is 4-Fluoroisobenzofuran-1,3-dione

A Rational Design, Synthesis, Biological Evaluation and Structure-Activity Relationship Study of Novel Inhibitors against Cyanobacterial Fructose-1,6-bisphosphate Aldolase

In the present study, a series of novel maleimide derivatives were rationally designed and optimized, and their inhibitory activities against cyanobacteria class-II fructose-1,6-bisphosphate aldolase (Cy-FBA-II) and Synechocystis sp. PCC 6803 were further evaluated. The experimental results showed that the introduction of a bigger group (Br, Cl, CH3, or C6H3-o-F) on the pyrrole-2?,5?-dione ring resulted in a decrease in the Cy-FBA-II inhibitory activity of the hit compounds. Generally, most of the hit compounds with high Cy-FBA-II inhibitory activities could also exhibit high in vivo activities against Synechocystis sp. PCC 6803. Especially, compound 10 not only shows a high Cy-FBA-II activity (IC50 = 1.7 muM) but also has the highest in vivo activity against Synechocystis sp. PCC 6803 (EC50 = 0.6 ppm). Thus, compound 10 was selected as a representative molecule, and its probable interactions with the surrounding important residues in the active site of Cy-FBA-II were elucidated by the joint use of molecular docking, molecular dynamics simulations, ONIOM calculations, and enzymatic assays to provide new insight into the binding mode of the inhibitors and Cy-FBA-II. The positive results indicate that the design strategy used in the present study is very likely to be a promising way to find novel lead compounds with high inhibitory activities against Cy-FBA-II in the future. The enzymatic and algal inhibition assays suggest that Cy-FBA-II is very likely to be a promising target for the design, synthesis, and development of novel specific algicides to solve cyanobacterial harmful algal blooms.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H2530O – PubChem