Category: 6296-53-3

Synthetic Route of 6296-53-3, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 6296-53-3, N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, introducing its new discovery.

A process for the resolution of racemic 2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine using novel chiral salts is disclosed. An L-phenylalanine p-toluene-sulfonamide salt of (S)-2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine and a di-p-toluoyl-L-tartaric acid salt of (S)-2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine are also provided.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 6296-53-3. In my other articles, you can also check out more blogs about 6296-53-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3425O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Application In Synthesis of N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 6296-53-3

The invention relates to a preparation method of (S)-l-(3-ethoxy-4-methoxyphenyl)- 2-(methylsulfonyl)-ethyl-amine (S)-l, or its N-acyl derivatives of general formula (S)-2. The amine (S)-l is the key intermediate in the synthesis of (S)-{2-[l-(3-ethoxy-4- methoxyphenyi)-2-methyisulfonylethyl]-4-acetylaminoisoindolin-l ?3-dione, known as Apremilast. In this synthesis, the amine (S)-l, or its respective salts, are subjected to condensation with 3-acetamidophthalic anhydride 4, providing the desired product 3 (Scheme 1).

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3428O – PubChem

Reference of 6296-53-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4. In a Patent，once mentioned of 6296-53-3

The present invention relates to an improved process for the preparation of Apremilast of formula (I).

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 6296-53-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3455O – PubChem

Electric Literature of 6296-53-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4. In a Article，once mentioned of 6296-53-3

Poly(aminophthalimide) (PAP) dimers and trimers have been synthesized by palladium-catalyzed cross-coupling reactions of 3-aminophthalimides with 3-chloro- and 3,6-dichlorophthalimide, respectively. When Pd(OAc)2, XPhos (2-dicyclohexylphosphino-2?,4?,6?-triisopropylbiphenyl), and K3PO4 are used, the C-N bond-forming reactions proceed quantitatively. The structures of those oligomers are examined by experimental and theoretical techniques including NMR, IR, single-crystal X-ray diffraction, and DFT calculations. The strong preference for cisoid structure of the diphthalimidylamine unit bearing a bifurcate hydrogen bonding is disclosed. Therefore, the aminophthalimide backbone is a highly promising candidate for the construction of a dynamically ordered helical structure.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 6296-53-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3484O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Safety of N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 6296-53-3

The present invention relates to a process for the preparation of 1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethanamine, an intermediate for the preparation of apremilast via a compound of Formula (V) wherein R is (C1-C4)alkyl, (C1-C4)haloalkyl, -O(C1-C4)alkyl, or ?O-benzyl, and L is a leaving group.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3472O – PubChem

Related Products of 6296-53-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4. In a Patent，once mentioned of 6296-53-3

The invention discloses a apps is special of effecting the purity of the preparation method, 2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)-b-2-amine and N-acetyl-L-leucine salt forming reaction to obtain (S)-2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)-b-2-ylamine-N-acetyl-L-leucine salt, the purified (S)-2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)-b-2-ylamine-? N-acetyl-L-leucine salt with 3-acetyl amino phthalic anhydride in the presence of toluene and acetic acid react to generate the receive? (S)-2-[ 1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetyl amino indoline -1, 3-diketone, through the acetone and ethanol mixed solvent recrystallization to obtain stereomeride relatively pure apps is special. The advantage of this invention lies in: the invention by replacing the solvent, adding catalyst, reaction time is greatly shortened, the chiral purity as high as 99.8% apps is special of. (by machine translation)

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3441O – PubChem

Application of 6296-53-3, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4. In a Article£¬once mentioned of 6296-53-3

Tilivalline 1, a metabolite from Klebsiella pneumoniae var. ocytoca, was easily synthesized in five steps from (S)-proline and 3-(benzyloxy)isatoic anhydride 4g. This synthesis is based on modified Curtius reactions of 3- substituted phthalic anhydrides 11 to 3-substituted isatoic anhydrides 4, conversion of lactams 6 to the acyliminium precursors 7 and stereoselective introduction of indole from the less hindered side of 7.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 6296-53-3. In my other articles, you can also check out more blogs about 6296-53-3

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3486O – PubChem

6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, belongs to benzofurans compound, is a common compound. name: N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamideIn an article, once mentioned the new application about 6296-53-3.

Methods of treating a disease selected from dermatomyositis, prurigo nodularis, pyoderma gangrenosum, alopecia areata, hidradenitis suppurtiva, rosacea, lichen planus, giant cell arteritis, Sjogren’s syndrome, gout, chronic prostatitis, posterior uveitis, vulvodynia and interstitial cystitis in a human are disclosed. Specific methods encompass the administration of (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, cyclopropyl {2-[(15)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindolin-4-yl}carboxamide or a combination thereof, or a pharmaceutically acceptable prodrug, metabolite, polymorph, salt, solvate or clathrate thereof.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3463O – PubChem

Synthetic Route of 6296-53-3, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide,introducing its new discovery.

The present invention provides novel crystalline forms of apremilast hemitoluene solvate, apremilast hydrate, and apremilast anhydrate and an amorphous form of apremilast, and processes for the preparation of these forms.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 6296-53-3, and how the biochemistry of the body works.Synthetic Route of 6296-53-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3432O – PubChem

6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, belongs to benzofurans compound, is a common compound. name: N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamideIn an article, once mentioned the new application about 6296-53-3.

Preparation of diversely substituted beta-functionalised styrenes by microwave-assisted olefin cross-metathesis (CM) is described. This method can be also employed in the synthesis of beta-deuterated alpha,beta-unsaturated sulfones from inexpensive allylbenzenes, though unprecedented one-pot isomerisation/deuteration/cross-metathesis sequence. One of such obtained CM products has been utilised in a new scalable synthesis of Apremilast (6), a potent and orally active phosphodiesterase 4 and tumour necrosis factor-alpha inhibitor. The same strategy was used in synthesis of an optical antipode of 6, ent-Apremilast.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3483O – PubChem