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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Product Details of 569-31-3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 569-31-3, Name is 6,7-Dimethoxy-3H-1-isobenzofuranone, molecular formula is C10H10O4

Determination of Neutral Manufacturing Impurities in Heroin by Capillary Gas Chromatography with Electron Capture Detection after Reduction with Lithium Aluminum Hydride and Derivatization with Heptafluorobutyric Anhydride

Neutral byproducts associated with the manufacture of illicit heroin are many and include meconin, 4-acetoxy-3,6-dimethoxyphenanthrene, N,O6-diacetylnorcodeine, 4-acetoxy-3,6-dimethoxy-5-<2-(N-methylacetamido)ethyl>phenanthrene, N,O3,O6-triacetylnormorphine, and 4-acetoxy-3,6-dimethoxy-8-<2-(N-metnylacetamido)ethyl>phenanthrene.These N- and O-acetylated impurities, and meconin, are easily isolated from the bulk heroin matrix, after which they are subjected to reduction with lithium aluminum hydride (LiAlH4) followed by derivatization with heptafluorobutyric anhydride (HFBA) in the presence of pyridine.The resultant haptafluorobutyryl (HFB) electrophiles are detected on-column at picogram (pg) levels by using capillary column gas chromatography/electron capture detection (CC/GC/ECD) in the splitless mode.The method is applicable for the in-depth analyses of crudely processed and highly refined heroin samples.

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Benzofuran – Wikipedia,
Benzofuran | C8H3145O – PubChem

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Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 569-31-3. In my other articles, you can also check out more blogs about 569-31-3

Synthetic Route of 569-31-3, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 569-31-3, Name is 6,7-Dimethoxy-3H-1-isobenzofuranone, molecular formula is C10H10O4. In a Article£¬once mentioned of 569-31-3

Directed ortho metalation of n,n-diethyl benzamides. Methodology and regiospecific synthesis of useful contiguously tri- and tetra-substituted oxygenated aromatics, phthalides and phthalic anhydrides

Full experimental details for the directed ortho metalation approch to a variety of simple ortho-substituted N,N-diethyl benzamides (Table 1) and contiguously 1,2,3- and 1,2,3,4-substituted benzamides (Tables 2) are given. The efficient conversion of these benzamides (6, 10, 12, 13, 18, 19) into phthalides (9a-b, 16b-c, 17) and phthalic anhydrides (8,16a), compounds previously available by demanding, classical methods, is detailed. A short synthesis of iso-ochracinic acid (27) is described.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 569-31-3. In my other articles, you can also check out more blogs about 569-31-3

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3129O – PubChem

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569-31-3,569-31-3, 6,7-Dimethoxy-3H-1-isobenzofuranone is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Isobenzofuran-1(3H)-one (0.4 mmol), KOH (0.4 mmol), PhSiH3 (1.2 mmol), dried THF (2 mL) were charged in a Schlenk tube(15 mL) under N2 atmosphere. The mixture was refluxed for 4 h. After cooling to rt, the reaction was quenched with EtOH(0.5-1 mL). Solvent was removed under reduced pressure and the crude residue was purified by column chromatography on silica gel with petroleum ether-ethyl acetate as the eluent to afford the desired product.

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Reference£º
Article; Liu, Bin; Zhou, Xigeng; Chinese Chemical Letters; vol. 30; 3; (2019); p. 725 – 728;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

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The synthetic route of 569-31-3 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.569-31-3,6,7-Dimethoxy-3H-1-isobenzofuranone,as a common compound, the synthetic route is as follows.,569-31-3

Example V — SYNTHESIS OF 3-[N(BENZODIOXAN-1,4 YL-6) AMINO] 6,7-DIMETHOXY 3H-ISOBENZOFURANONE A mixture of 30 g of 6,7-dimethoxy 3H-isobenzofuranone, prepared according to the method described in Example IV, 1 liter of ethanol and 300-400 cm3 of dimethylamine was agitated for several hours and then evaporated under vacuum at 30 – 35 C. The crystallized product was washed with heptane. The 2,3-dimethoxy N,N-dimethyl 6-hydroxymethyl benzamide was obtained in a yield of 100%. F = 90 C.

The synthetic route of 569-31-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Societe Cortial; US4122202; (1978); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Analyzing the synthesis route of 569-31-3

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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.569-31-3,6,7-Dimethoxy-3H-1-isobenzofuranone,as a common compound, the synthetic route is as follows.

A solution of Compound 31a (6.31 g, 32.5 mmol) in acetonitrile (60 mL) was added NCS (4.77 g, 35.7 mmol) . After stirring at 60 C for 1 hour, the insoluble matter was collected by filtration, so as to yield compound 31b. Yield: 6.15 g, (83%) 1H-N R (CDC13) delta: 3.91 (3H,’s), 4.09 (3H, s) , 5.15 (2H, s), 7.16 (1H, s) .

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Reference£º
Patent; GLAXO GROUP LIMITED; SHIONOGI & CO., LTD.; LIAO, Xiangmin; PEARSON, Neil, David; PENDRAK, Israil; THALGI, Reema; YAMAWAKI, Kenji; YOKOO, Katsuki; SATO, Jun; KUSANO, Hiroki; AOKI, Toshiaki; WO2014/68388; (2014); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

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569-31-3 6,7-Dimethoxy-3H-1-isobenzofuranone 68437, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.569-31-3,6,7-Dimethoxy-3H-1-isobenzofuranone,as a common compound, the synthetic route is as follows.

To a solution of compound 31a (6.31 g, 32.5 mmol) in acetonitrile (60 mL) was added NCS (4.77 g, 35.7 mmol). After stirring at 60 C. for 1 hour, the insoluble matter was collected by filtration, whereby Compound 31b was obtained.

569-31-3 6,7-Dimethoxy-3H-1-isobenzofuranone 68437, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXO GROUP LIMITED; YAMAWAKI, KENJI; YOKOO, KATSUKI; SATO, JUN; KUSANO, HIROKI; AOKI, TOSHIAKI; LIAO, XIANG MIN; PEARSON, NEIL DAVID; PENDRAK, ISRAIL; THALGI, REEMA; (373 pag.)JP6377570; (2018); B2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem